Compounds > 8-hydroxydeoxyguanosine 5'-monophosphate
Page last updated: 2024-10-15

8-hydroxydeoxyguanosine 5'-monophosphate

Description

8-oxo-dGMP : A purine 2'-deoxyribonucleoside 5'-monophosphate having 8-oxo-7,8-dihydroguanine as the nucleobase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID135488904
CHEBI ID63223
SCHEMBL ID2388172
MeSH IDM0175197

Synonyms (32)

Synonym
8-oxo-2'-deoxy-guanosine-5'-monophosphate
8OG ,
1PUN
1PPX
8-oxo-2'-deoxyguanosine-5'-monophosphate
1PUS
8-hydroxydeoxyguanosine 5'-monophosphate
1PUQ
8-oh-dgmp
DB02023
2'-deoxy-7,8-dihydro-8-oxoguanosine 5'-monophosphate
2'-deoxy-7,8-dihydro-8-oxo-5'-guanylic acid
8-oxo-dgmp
8-oxo-7,8-dihydro-2'-deoxy-guanosine-5'-monophosphate
[(2r,3s,5r)-5-(2-amino-6,8-dioxo-3,7-dihydropurin-9-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
2'-deoxy-7,8-dihydro-8-oxo-5'-guanylate
C19968
5'-guanylic acid, 2'-deoxy-7,8-dihydro-8-oxo-
127027-50-3
CHEBI:63223
2'-deoxy-8-oxo-7,8-dihydroguanosine 5'-(dihydrogen phosphate)
8-oxo-7,8-di-hydro-2' -deoxyguanosine-5' -monophosphate
SCHEMBL2388172
[(2r,3s,5r)-5-(2-amino-6,8-dioxo-1,7-dihydropurin-9-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
8-hydroxydeoxy-guanosine 5'-monophosphate
2'-deoxy-8-oxoguanosine 5'-(dihydrogen phosphate)
9-(2-deoxy-5-o-phosphonopentofuranosyl)-2-imino-3,9-dihydro-2h-purine-6,8-diol
DTXSID40925768
Q27132489
((2r,3s,5r)-5-(2-amino-6,8-dioxo-7,8-dihydro-3h-purin-9(6h)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
PD060155
{[(2r,3s,5r)-5-(2-amino-6,8-dioxo-6,7,8,9-tetrahydro-3h-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
purine 2'-deoxyribonucleoside 5'-monophosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Mutator mutT proteinEscherichia coliKd0.05200.05200.05200.0520AID977611
Chain A, Mutator mutT proteinEscherichia coliKd0.05200.05200.05200.0520AID977611
Chain A, Mutator mutT proteinEscherichia coliKd0.05200.05200.05200.0520AID977611
Chain A, Mutator mutT proteinEscherichia coliKd0.05200.05200.05200.0520AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1811Experimentally measured binding affinity data derived from PDB2003Biochemistry, Sep-02, Volume: 42, Issue:34
Solution structure and NH exchange studies of the MutT pyrophosphohydrolase complexed with Mg(2+) and 8-oxo-dGMP, a tightly bound product.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2003Biochemistry, Sep-02, Volume: 42, Issue:34
Solution structure and NH exchange studies of the MutT pyrophosphohydrolase complexed with Mg(2+) and 8-oxo-dGMP, a tightly bound product.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
deoxyguanosine
[no description available]		3.1110purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
guanosine monophosphate
Guanosine Monophosphate: A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.. guanosine 5'-monophosphate : A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase.		3.7930guanosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		biomarker;
Escherichia coli metabolite;
metabolite;
mouse metabolite
guanine
[no description available]		3.52202-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
8-hydroxyguanine
7,8-dihydro-8-oxoguanine: was substituted for guanine at G(8), G(9), G(14), or G(15) in the human telomeric oligonucleotide 5'-d[AGGGTTAG(8)G(9)GTT AG(14)G(15)GTTAGGGTGT]-3'. 7,8-dihydro-8-oxoguanine : An oxopurine that is guanine in which the hydrogen at position 8 is replaced by an oxo group and in which the nitrogens at positions 7 and 9 each bear a hydrogen.		3.5220oxopurine
8-hydroxy-2'-deoxyguanosine
8-Hydroxy-2'-Deoxyguanosine: Common oxidized form of deoxyguanosine in which C-8 position of guanine base has a carbonyl group.. 8-hydroxy-2'-deoxyguanosine : Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.		3.1110guanosinesbiomarker
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinoma, Anaplastic
[description not available]		02.0110
Cancer of Lung
[description not available]		02.0110
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0110