Page last updated: 2024-10-15

8-hydroxydeoxyguanosine 5'-monophosphate

Description

8-oxo-dGMP : A purine 2'-deoxyribonucleoside 5'-monophosphate having 8-oxo-7,8-dihydroguanine as the nucleobase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID135488904
CHEBI ID63223
SCHEMBL ID2388172
MeSH IDM0175197

Synonyms (32)

Synonym
8-oxo-2'-deoxy-guanosine-5'-monophosphate
8OG ,
1PUN
1PPX
8-oxo-2'-deoxyguanosine-5'-monophosphate
1PUS
8-hydroxydeoxyguanosine 5'-monophosphate
1PUQ
8-oh-dgmp
DB02023
2'-deoxy-7,8-dihydro-8-oxoguanosine 5'-monophosphate
2'-deoxy-7,8-dihydro-8-oxo-5'-guanylic acid
8-oxo-dgmp
8-oxo-7,8-dihydro-2'-deoxy-guanosine-5'-monophosphate
[(2r,3s,5r)-5-(2-amino-6,8-dioxo-3,7-dihydropurin-9-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
2'-deoxy-7,8-dihydro-8-oxo-5'-guanylate
C19968
5'-guanylic acid, 2'-deoxy-7,8-dihydro-8-oxo-
127027-50-3
CHEBI:63223
2'-deoxy-8-oxo-7,8-dihydroguanosine 5'-(dihydrogen phosphate)
8-oxo-7,8-di-hydro-2' -deoxyguanosine-5' -monophosphate
SCHEMBL2388172
[(2r,3s,5r)-5-(2-amino-6,8-dioxo-1,7-dihydropurin-9-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
8-hydroxydeoxy-guanosine 5'-monophosphate
2'-deoxy-8-oxoguanosine 5'-(dihydrogen phosphate)
9-(2-deoxy-5-o-phosphonopentofuranosyl)-2-imino-3,9-dihydro-2h-purine-6,8-diol
DTXSID40925768
Q27132489
((2r,3s,5r)-5-(2-amino-6,8-dioxo-7,8-dihydro-3h-purin-9(6h)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
PD060155
{[(2r,3s,5r)-5-(2-amino-6,8-dioxo-6,7,8,9-tetrahydro-3h-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
purine 2'-deoxyribonucleoside 5'-monophosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Mutator mutT proteinEscherichia coliKd0.05200.05200.05200.0520AID977611
Chain A, Mutator mutT proteinEscherichia coliKd0.05200.05200.05200.0520AID977611
Chain A, Mutator mutT proteinEscherichia coliKd0.05200.05200.05200.0520AID977611
Chain A, Mutator mutT proteinEscherichia coliKd0.05200.05200.05200.0520AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1811Experimentally measured binding affinity data derived from PDB2003Biochemistry, Sep-02, Volume: 42, Issue:34
Solution structure and NH exchange studies of the MutT pyrophosphohydrolase complexed with Mg(2+) and 8-oxo-dGMP, a tightly bound product.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2003Biochemistry, Sep-02, Volume: 42, Issue:34
Solution structure and NH exchange studies of the MutT pyrophosphohydrolase complexed with Mg(2+) and 8-oxo-dGMP, a tightly bound product.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]