8-bromo-2'-deoxyadenosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

8-bromo-2'-deoxyadenosine is a synthetic nucleoside analog that acts as a potent inhibitor of DNA polymerase alpha. It is used in research to study the mechanisms of DNA replication and repair. The compound is synthesized by bromination of 2'-deoxyadenosine. Its effects on DNA replication are attributed to its ability to bind to the active site of DNA polymerase alpha, inhibiting the enzyme's activity. This inhibition can lead to the accumulation of DNA lesions, which can trigger cell cycle arrest and apoptosis. 8-bromo-2'-deoxyadenosine has also been shown to have anti-tumor activity in vitro and in vivo. It is currently being investigated as a potential therapeutic agent for the treatment of cancer. 8-bromo-2'-deoxyadenosine is a useful tool for studying the role of DNA polymerase alpha in DNA replication and repair. It is also a potential therapeutic agent for the treatment of cancer.'

Cross-References

ID Source	ID
PubMed CID	96547
SCHEMBL ID	440599
MeSH ID	M0125398

Synonyms (19)

Synonym
8-bromo-2'-deoxyadenosine
14985-44-5
(2r,3s,5r)-5-(6-amino-8-bromo-9h-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
nsc 79220
2'-deoxy-8-bromoadenosine
adenosine, 8-bromo-2'-deoxy-
8-b-2-da
HG1031
SCHEMBL440599
adenosine,8-bromo-2'-deoxy-
(2r,3s,5r)-5-(6-amino-8-bromo-9h-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
8-bromo-2??-deoxyadenosine
AKOS024258314
NJBIVXMQFIQOGE-KVQBGUIXSA-N ,
AC-32298
mfcd01630970
AS-59393
5-(6-amino-8-bromo-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol
8-bromo-2'-deoxy-d-adenosine

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (8.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (41.67)	29.6817
2010's	5 (41.67)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.76 (24.57)
Research Supply Index	2.64 (2.92)
Research Growth Index	4.40 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.76)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ammonium hydroxide azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.	2.01	1	azane; gas molecular entity; mononuclear parent hydride	EC 3.5.1.4 (amidase) inhibitor; metabolite; mouse metabolite; neurotoxin; NMR chemical shift reference compound; nucleophilic reagent; refrigerant
thymidine [no description available]	2.15	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
bromouracil Bromouracil: 5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.. 5-bromouracil : A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen.	2.15	1	nucleobase analogue; pyrimidines	mutagen
uridine [no description available]	2.15	1	uridines	drug metabolite; fundamental metabolite; human metabolite
bromodeoxyuridine Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.	2.15	1	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent
adenosine monophosphate Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.	2.01	1	adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate	adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
2'-deoxyadenosine 2'-deoxyformycin A: RN not in Chemline 9/85; RN and structure given in first source	2.01	1	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.13	1	metal allergen; nickel group element atom; platinum group metal atom
azides Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.	2.01	1	pseudohalide anion	mitochondrial respiratory-chain inhibitor
5-bromouridine 5-bromouridine : A uridine having a bromo substituent at the 5-position.	2.15	1	uridines	mutagen
8-oxo-dado 2'-deoxy-7,8-dihydro-8-oxoadenosine: structure given in first source	2.41	1
bromodeoxycytidine Bromodeoxycytidine: 5-Bromo-2'-deoxycytidine. Can be incorporated into DNA in the presence of DNA polymerase, replacing dCTP.	2.5	2
phosphoramidite phosphoramidite: structure in first source. phosphoramidite : A compound with the general formula (RO)2PNR2. Phosphoramidites can be regarded as phosphites that have an NR2 instead of an OH group, or as amides of phosphorous acid.	2.13	1
oligonucleotides [no description available]	2.79	3
deoxyguanosine [no description available]	2.8	3	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanine [no description available]	2.15	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
8-bromoguanine 8-bromoguanine: structure in first source	2.15	1
8-bromo-2'-deoxyguanosine 8-bromo-2'-deoxyguanosine: structure in first source. 8-bromo-2'-deoxyguanosine : An organobromine compound comprising 2'-deoxyguanosine having a bromo substituent at position 8 of the guanine ring system.	2.8	3	guanosines; organobromine compound

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