Page last updated: 2024-12-07

8-bromo-2'-deoxyadenosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

8-bromo-2'-deoxyadenosine is a synthetic nucleoside analog that acts as a potent inhibitor of DNA polymerase alpha. It is used in research to study the mechanisms of DNA replication and repair. The compound is synthesized by bromination of 2'-deoxyadenosine. Its effects on DNA replication are attributed to its ability to bind to the active site of DNA polymerase alpha, inhibiting the enzyme's activity. This inhibition can lead to the accumulation of DNA lesions, which can trigger cell cycle arrest and apoptosis. 8-bromo-2'-deoxyadenosine has also been shown to have anti-tumor activity in vitro and in vivo. It is currently being investigated as a potential therapeutic agent for the treatment of cancer. 8-bromo-2'-deoxyadenosine is a useful tool for studying the role of DNA polymerase alpha in DNA replication and repair. It is also a potential therapeutic agent for the treatment of cancer.'

Cross-References

ID SourceID
PubMed CID96547
SCHEMBL ID440599
MeSH IDM0125398

Synonyms (19)

Synonym
8-bromo-2'-deoxyadenosine
14985-44-5
(2r,3s,5r)-5-(6-amino-8-bromo-9h-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
nsc 79220
2'-deoxy-8-bromoadenosine
adenosine, 8-bromo-2'-deoxy-
8-b-2-da
HG1031
SCHEMBL440599
adenosine,8-bromo-2'-deoxy-
(2r,3s,5r)-5-(6-amino-8-bromo-9h-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
8-bromo-2??-deoxyadenosine
AKOS024258314
NJBIVXMQFIQOGE-KVQBGUIXSA-N ,
AC-32298
mfcd01630970
AS-59393
5-(6-amino-8-bromo-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol
8-bromo-2'-deoxy-d-adenosine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (8.33)18.7374
1990's0 (0.00)18.2507
2000's5 (41.67)29.6817
2010's5 (41.67)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.76 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.40 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]