Page last updated: 2024-12-08

7-thiomethylspirolactone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

7-thiomethylspirolactone: spironolactone metabolite; RN refers to (7alpha,17alpha)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID162325
CHEMBL ID3544705
SCHEMBL ID18157022
MeSH IDM0134860

Synonyms (35)

Synonym
7-thiomethylspirolactone
7|a-thiomethyl spironolactone
(7r,8r,9s,10r,13s,14s,17r)-10,13-dimethyl-7-methylsulfanylspiro[2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
7-a-thiomethyl spironolactone
7alpha-thiomethyl-sl
unii-0yu66jy4wl
38753-77-4
7alpha-thiomethylspironolactone
pregn-4-ene-21-carboxylic acid, 17-hydroxy-7-(methylthio)-3-oxo-, gamma-lactone, (7alpha,17alpha)-
7alpha-thiomethylspirolactone
0yu66jy4wl ,
7a-thiomethylspironolactone
SC-26519 ,
7.alpha.-(thiomethyl)spirolactone
(7r,8r,9s,10r,13s,14s,17r)-10,13-dimethyl-7-methylsulfanyl-spiro(2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta(a)phenanthrene-17,5'-tetrahydrofuran)-2',3-dione
7-de(acetylthio)-7.alpha.-(methylthio)spironolactone
spironolactone metabolite m4
7.alpha.-thiomethylspironolactone
3-(3-oxo-7.alpha.-methylthio-17.beta.-hydroxy-4-androsten-17.alpha.-yl)propionic acid .gamma.-lactone
7.alpha.-(methylthio)spironolactone
7.alpha.-(thiomethyl)spironolactone
CHEMBL3544705
(2'r,7r,8r,9s,10r,13s,14s)-10,13-dimethyl-7-(methylthio)-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3'h-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2h,4'h)-dione
SCHEMBL18157022
7-alpha-thiomethyl spironolactone
(2'r,7r,8r,10r,13s,14s)-10,13-dimethyl-7-(methylthio)-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3'h-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2h,4'h)-dione
AKOS032958181
Q27237364
7 alpha -thiomethyl spironolactone
17a-hydroxy-7a-(methylthio)-3-oxo-pregn-4-ene-21-carboxylic acid gamma-lactone
DTXSID80959567
10,13-dimethyl-7-(methylsulfanyl)-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-oxolane]-3,5'(2h)-dione
7| inverted exclamation mark-(thiomethyl)spironolactone
7?-thiomethyl spironolactone
PD151134

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Main pharmacokinetic parameters have been calculated using a biexponential (ALT and SPI) or a triexponential model (7TM and CAN)."( [Pharmacokinetics in healthy subjects of althiazide and spironolactone in a fixed combination for 2 doses].
Caplain, M; Capron, MH; Doignon, JL; Grognet, JM; Istin, M; Pelletier, B; Thébault, JJ; Wehrlen, M,
)
0.13
" Pharmacokinetic parameters were derived from the serum concentration-time course of each compound."( New insights into the pharmacokinetics of spironolactone.
Hermens, WA; Merkus, FW; Overdiek, HW, 1985
)
0.27

Bioavailability

ExcerptReferenceRelevance
"The mean (95% confidence limits) relative bioavailability for SP-COMP (compared with ALD) from steady state serum concentrations of canrenone, 6beta-hydroxyl 7alpha-thiomethyl spironolactone and 7alpha-thiomethyl spironolactone was 310."( Improved bioavailability and clinical response in patients with chronic liver disease following the administration of a spironolactone: beta-cyclodextrin complex.
Abosehmah-Albidy, AZ; Chrystyn, H; Losowsky, MS; Wong, V; York, P, 1997
)
0.3

Dosage Studied

ExcerptRelevanceReference
" Our findings are contrary to the widely accepted belief that spironolactone is metabolized too rapidly to be detected in serum after oral dosing and that canrenone is the principal metabolite of spironolactone."( New insights into the pharmacokinetics of spironolactone.
Hermens, WA; Merkus, FW; Overdiek, HW, 1985
)
0.27
"Better absorption of spironolactone from the spironolactone: beta-cyclodextrin complex formulation should lead to a reduction in dosage and perhaps a more consistent effect in patients with chronic liver disease."( Improved bioavailability and clinical response in patients with chronic liver disease following the administration of a spironolactone: beta-cyclodextrin complex.
Abosehmah-Albidy, AZ; Chrystyn, H; Losowsky, MS; Wong, V; York, P, 1997
)
0.3
" For investigation of bioequivalence of 2 oral spironolactone formulations, Spironolacton 50 Heumann and Aldactone 50, the pharmacokinetics and bioequivalence of the parent drug and 2 predominant active metabolites, canrenone and 7 alpha-thiomethylspirolactone, were determined in a 2-way crossover study in 24 young healthy male volunteers after multiple oral dosing of 100 mg once daily."( Analysis of metabolites--a new approach to bioequivalence studies of spironolactone formulations.
Eichinger, A; Mahr, G; Martens, H; Metz, R; Nitsche, V; Vergin, H, 1997
)
0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (41.67)18.7374
1990's5 (41.67)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.47 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (30.77%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (69.23%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]