7-hydroxynalidixic acid profile

7-hydroxynalidixic acid: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	160716
CHEBI ID	188407
SCHEMBL ID	11884240
MeSH ID	M0059341

Synonyms (14)

Synonym
7-hydroxynalidixic acid
3759-18-0
CHEBI:188407
1-ethyl-7-(hydroxymethyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid
hydroxynalidixic acid
nzj3r8s4eh ,
7-(hydroxymethyl)nalidixic acid
1-ethyl-1,4-dihydro-7-(hydroxymethyl)-4-oxo-1,8-naphthyrid ine-3-carboxylic acid
unii-nzj3r8s4eh
SCHEMBL11884240
DTXSID20191025
1,8-naphthyridine-3-carboxylic acid, 1-ethyl-1,4-dihydro-7-(hydroxymethyl)-4-oxo-
1-ethyl-1,4-dihydro-7-hydroxymethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
hydroxynalidixinic acid

Drug Classes (1)

Class	Description
naphthyridine derivative	Any organonitrogen heterocyclic compound that is a derivative of a naphthyridine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (62.50)	18.7374
1990's	3 (37.50)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.18 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.38 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.18)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
nalidixic acid [no description available]	3.47	8	1,8-naphthyridine derivative; monocarboxylic acid; quinolone antibiotic	antibacterial drug; antimicrobial agent; DNA synthesis inhibitor
probenecid Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.. probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.	1.98	1	benzoic acids; sulfonamide	uricosuric drug
7-carboxynalidixic acid 7-carboxynalidixic acid: metabolite of nalidixic acid; structure given in first source	3.22	6	naphthyridine derivative

Condition	Indicated	Relationship Strength	Studies	Trials
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	0	1.96	1	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2	1	0

7-hydroxynalidixic acid

Description