7-hydroxymethylbenz(a)anthracene

Description

7-Hydroxymethylbenz(a)anthracene (7-OHM-BaA) is a potent carcinogenic polycyclic aromatic hydrocarbon (PAH) that has been extensively studied for its role in the development of cancer. It is a derivative of benz(a)anthracene, a known environmental contaminant. 7-OHM-BaA has been found in various environmental matrices, including coal tar, diesel exhaust, and cigarette smoke. Its synthesis typically involves the reaction of benz(a)anthracene with formaldehyde, producing 7-OHM-BaA and its isomers. This compound has been shown to be highly mutagenic and carcinogenic in laboratory animals. It acts as a potent mutagen by inducing DNA damage, leading to mutations that can contribute to the development of cancer. 7-OHM-BaA has also been implicated in the initiation and promotion of tumor growth in several organs, including skin, lung, and bladder. Its carcinogenic potency has spurred research into its biological effects, focusing on its metabolism, DNA binding, and mechanisms of action. By understanding the carcinogenic properties of 7-OHM-BaA, scientists can develop strategies to prevent and treat cancer related to environmental exposures to PAHs.'

7-hydroxymethylbenz(a)anthracene: RN given refers to unlabeled parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]