Compounds > 7-hydroxy-6-methyl-8-(1-d-ribityl)lumazine
Page last updated: 2024-12-08

7-hydroxy-6-methyl-8-(1-d-ribityl)lumazine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

photolumazine C: inhibitor of riboflavin synthetase; isolated from Photobacterium phosphoreum; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

6-methyl-7-oxo-8-(1-D-ribityl)lumazine (2-oxo tautomer) : A D-ribityl derivative of pteridine that is a potent inhibitor of riboflavin synthetase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

6-methyl-7-oxo-8-(1-D-ribityl)lumazine (2-hydroxy tautomer) : A pteridine that is lumazine substituted by methyl and oxo groups at C-6 and -7 respectively as well as a 1-D-ribityl group on N-8. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

7-hydroxy-6-methyl-8-(1-D-ribityl)lumazine : The pteridine that is lumazine substituted with a methyl group at C-6, a hydroxy group at C-7 and a 1-D-ribityl group at N-8. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID440869
CHEBI ID60900
CHEBI ID27581
CHEBI ID73090
SCHEMBL ID15603800
SCHEMBL ID11754109
MeSH IDM0052068

Synonyms (28)

Synonym
CHEBI:60900
1-deoxy-1-(6-methyl-2,4,7-trioxo-1,3,4,7-tetrahydropteridin-8(2h)-yl)-d-ribitol
6-methyl-7-oxo-8-(1-d-ribityl)lumazine (2-oxo tautomer)
photolumazine c
6-methyl-7-oxo-8-ribityllumazine
C05995
7-hydroxy-6-methyl-8-ribityllumazine
6-methyl-8-[(2s,3s,4r)-2,3,4,5-tetrahydroxypentyl]-1h-pteridine-2,4,7-trione
masuda's compound v
7-hydroxy-6-methyl-8-d-ribityllumazine
1-deoxy-1-(3,4-dihydro-7-hydroxy-6-methyl-2,4-dioxo-8(2h)-pteridinyl)-d-ribitol
7-hydroxy-6-methyl-8-(1-d-ribityl)lumazine
rl-6-me-7-oh
CHEBI:27581 ,
1-deoxy-1-(7-hydroxy-6-methyl-2,4-dioxo-3,4-dihydropteridin-8(2h)-yl)-d-ribitol
7-hydroxy-6-methyl-8-ribityl lumazine
6-methyl-7-oxo-8-(1-d-ribityl)lumazine (2-hydroxy tautomer)
CHEBI:73090
1-deoxy-1-(2-hydroxy-6-methyl-4,7-dioxo-1,7-dihydropteridin-8(4h)-yl)-d-ribitol
1vy ,
EPITOPE ID:178095
4L4V
SCHEMBL15603800
SCHEMBL11754109
QCYVUUAIJUUUPI-BBVRLYRLSA-N
Q27103208
DTXSID701289963
6-methyl-7-hydroxy-8-ribityllumazine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
EC 2.5.1.9 (riboflavin synthase) inhibitorAn EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that inhibits the action of riboflavin synthase (EC 2.5.1.9).
EC 2.5.1.9 (riboflavin synthase) inhibitorAn EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that inhibits the action of riboflavin synthase (EC 2.5.1.9).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
pteridines
pteridines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
Riboflavin Metabolism515

Bioassays (1)

Assay IDTitleYearJournalArticle
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2013Nature communications, , Volume: 4Recognition of vitamin B metabolites by mucosal-associated invariant T cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pteridines
[no description available]		2.8740azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
pteridines
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		2.2110pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		1.9710erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
xylitol
xylooligosaccharide: structure in first source. pentitol : An alditol obtained by reduction of any pentose.. xylooligosaccharide : An oligosaccharide comprised of xylose residues.		2.2110
riboflavin
vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).		2.6330flavin;
vitamin B2		anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials