Page last updated: 2024-12-08

7,8-dihydro-5,6-dehydrokawain

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

7,8-dihydro-5,6-dehydrokawain: from Alpinia speciosa rhizoma; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AlpiniagenusA plant genus of the family ZINGIBERACEAE. Members contain galangin, yakuchinone-A, and diarylheptanoids.[MeSH]ZingiberaceaeA plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).[MeSH]
Alpinia speciosaspecies[no description available]ZingiberaceaeA plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).[MeSH]
Alpinia speciosaspecies[no description available]ZingiberaceaeA plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).[MeSH]

Cross-References

ID SourceID
PubMed CID160673
CHEMBL ID1946699
CHEBI ID157717
SCHEMBL ID19679894
MeSH IDM0148494

Synonyms (19)

Synonym
5,6-ddk
3155-51-9
4-methoxy-6-(2-phenylethyl)pyran-2-one
dihydro-5,6-dehydrokawain
CHEBI:157717
2h-pyran-2-one, 4-methoxy-6-(2-phenylethyl)-
7,8-dihydro-5,6-dehydrokawain
CHEMBL1946699
4-methoxy-6-phenethyl-pyran-2-one
4-methoxy-6-(2-phenylethyl)-2h-pyran-2-one
2h-pyran-2-one, 4-methoxy-6-phenethyl-
4-methoxy-6-phenethyl-2h-pyran-2-one
OVXOWIKMOIVICB-UHFFFAOYSA-N
kawain, 5,6-dehydro-7,8-dihydro-
5,6-dehydro-7,8-dihydrokavain
2,4-heptadienoic acid, 5-hydroxy-3-methoxy-7-phenyl-, .delta.-lactone
5,6-didehydro-7,8-dihydrokawain
DTXSID10185453
SCHEMBL19679894
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
2-pyranonesA pyranone based on the structure of 2H-pyran-2-one and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID644367Antiprotozoal activity against Leishmania donovani MHOM/ET/67/L82 axenic amastigotes after 72 hrs by alamar blue assay2012Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4
Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.
AID1101272Toxicity against Brassica rapa assessed as plant growth inhibition at 100 ppm relative to untreated control2001Bioscience, biotechnology, and biochemistry, Jan, Volume: 65, Issue:1
Syntheses and biological activities of pyranyl-substituted cinnamates.
AID1105555Antifungal activity against Pythium sp. assessed as growth inhibition at 100 ppm by agar dilution method relative to control1996Bioscience, biotechnology, and biochemistry, Oct, Volume: 60, Issue:10
Syntheses and biological activities of dihydro-5,6-dehydrokawain derivatives.
AID644366Antiprotozoal activity against Trypanosoma cruzi Tulahuen C2C4 amastigotes infected in rat L6 myoblasts after 96 hrs by CPRG/Nonidet-based spectrophotometry2012Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4
Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.
AID644368Antiprotozoal activity against erythrocytic stages chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation pre-incubated for 48 hrs prior [3H]hypoxanthine addition measured after 24 hrs by2012Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4
Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.
AID1105554Antifungal activity against Athelia rolfsii assessed as growth inhibition at 100 ppm by agar dilution method relative to control1996Bioscience, biotechnology, and biochemistry, Oct, Volume: 60, Issue:10
Syntheses and biological activities of dihydro-5,6-dehydrokawain derivatives.
AID644365Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 trypomastigotes after 72 hrs by alamar blue assay2012Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4
Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.
AID1101273Antifungal activity against Rhizoctonia solani assessed as fungal growth inhibition at 100 ppm relative to untreated control2001Bioscience, biotechnology, and biochemistry, Jan, Volume: 65, Issue:1
Syntheses and biological activities of pyranyl-substituted cinnamates.
AID644364Antituberculosis activity against Mycobacterium tuberculosis H37Rv after 7 to 14 days by twofold serial broth dilution method2012Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4
Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.
AID1101274Antifungal activity against Sclerotium delphinii assessed as fungal growth inhibition at 100 ppm relative to untreated control2001Bioscience, biotechnology, and biochemistry, Jan, Volume: 65, Issue:1
Syntheses and biological activities of pyranyl-substituted cinnamates.
AID1105557Insecticidal activity against Coptotermes formosanus assessed as increase in mortality at 0.1 to 1 mg/filter paper measured for 14 days1996Bioscience, biotechnology, and biochemistry, Oct, Volume: 60, Issue:10
Syntheses and biological activities of dihydro-5,6-dehydrokawain derivatives.
AID1105552Antifungal activity against Athelia rolfsii assessed as growth inhibition at 1000 ppm by agar dilution method relative to control1996Bioscience, biotechnology, and biochemistry, Oct, Volume: 60, Issue:10
Syntheses and biological activities of dihydro-5,6-dehydrokawain derivatives.
AID644369Cytotoxicity against rat L6 myoblasts after 72 hrs by alamar blue assay2012Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4
Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.
AID1105553Antifungal activity against Pythium sp. assessed as growth inhibition at 1000 ppm by agar dilution method relative to control1996Bioscience, biotechnology, and biochemistry, Oct, Volume: 60, Issue:10
Syntheses and biological activities of dihydro-5,6-dehydrokawain derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's3 (33.33)18.2507
2000's2 (22.22)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.55

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.55 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.85 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.55)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]