Compounds > 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol
Page last updated: 2024-11-07

7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID156317
CHEBI ID82518
MeSH IDM0081903

Synonyms (42)

Synonym
ccris 992
trans-3,4-dihydro-3,4-dihydroxy-dmba
7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol
dmba-3,4-dihydrodiol,trans-
trans-3,4-dihydro-3,4-dihydroxy-7,12-dimethylbenz(a)anthracene
benz(a)anthracene, 3,4-dihydro-3,4-dihydroxy-7,12-dimethyl-, (e)-
3,4-dihydroxy-3,4-dihydro-7,12-dimethylbenz(a)anthracene
benz(a)anthracene-3,4-diol, 3,4-dihydro-7,12-dimethyl-
trans-7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol
brn 4500017
dmba 3,4-dihydrodiol
dmba-3,4-diol
(3s,4s)-7,12-dimethyl-3,4-dihydrobenzo[a]anthracene-3,4-diol
7,12-dimethyl-3,4-dihydrobenzo(a)anthracene-3,4-diol, (3s,4s)-
(3s,4s)-7,12-dimethyl-3,4-dihydrobenzo(a)anthracene-3,4-diol
unii-86lq63p8oj
92693-62-4
dmba-3s,4s-dihydrodiol
86lq63p8oj ,
C19490 ,
68162-13-0
trans-dmba-3,4-dihydrodiol
trans-3,4-dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
7,12-dimethyl-3,4-dihydrobenzo(a)anthracene-3,4-diol, trans-
dmba-3,4-dihydrodiol, trans-
u6aij1g484 ,
unii-u6aij1g484
74938-86-6
trans-(+-)-3,4-dihydro-7,12-dimethylbenz(a)anthracene-3,4-diol
benz(a)anthracene-3,4-diol, 3,4-dihydro-7,12-dimethyl-, trans-(+-)-
CHEBI:82518
3,4-dihydro-7,12-dimethylbenzo(a)anthracene-3,4-diol
benz(a)anthracene-3,4-diol, 3,4-dihydro-7,12-dimethyl-, (3s-trans)-
7,12-dimethyl-3,4-dihydrobenz(a)anthracene-3,4-diol
benz(a)anthracene-3,4-diol, 3,4-dihydro-7,12-dimethyl-, (3s,4s)-
j458.021d ,
7,12-dimethyl-3,4-dihydrobenzo(a)anthracene-3.alpha.,4.beta.-diol
(3s,4s)-7,12-dimethyl-3,4-dihydrotetraphene-3,4-diol
(3s,4s)-7,12-dimethyl-3,4-dihydro-3,4-tetraphenediol
3,4-dihydro-7,12-dimethylbenz(a)anthracene-3.alpha.,4.beta.-diol
j239.117a ,
Q27156032

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"Sexually immature rainbow trout were dosed via gavage with 7,12-[14C]dimethylbenz[a]anthracene (DMBA) in order to study hepatic metabolite formation over time and at single and multiple doses."( Time-varying conjugation of 7,12-dimethylbenz[a]anthracene metabolites in rainbow trout (Oncorhynchus mykiss).
O'Connor, JM; Schnitz, AR; Squibb, KS, 1993)		0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenanthrol
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's5 (71.43)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
9,10-dimethyl-1,2-benzanthracene
9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.		3.3870ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
benzo(a)pyrene 7,8-dihydrodiol
benzo(a)pyrene 7,8-dihydrodiol: RN given refers to cpd without isomeric designation		1.9510pyrenes
luteolin
[no description available]		2.03103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
ConditionIndicatedRelationship StrengthStudiesTrials
Granulocytic Leukemia, Chronic
[description not available]		02.0510
Acute Myelogenous Leukemia
[description not available]		02.0510
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.		02.0510
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		02.0510
Sarcoma, Epithelioid
[description not available]		02.0210
Experimental Mammary Neoplasms
[description not available]		02.4320
Sarcoma
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.		02.0210
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.0310
Papilloma, Squamous Cell
[description not available]		0210
Cancer of Skin
[description not available]		0210
Papilloma
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)		0210
Skin Neoplasms
Tumors or cancer of the SKIN.		0210