| Assay ID | Title | Year | Journal | Article |
|---|
| AID1898594 | Antischistosomal activity against adult stage of Schistosoma mansoni assessed as inhibition of parasite motility measured after 72 hrs | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. |
| AID143606 | Displacement of [3H]DCKA at N-methyl-D-aspartate glutamate receptor 1 | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors. |
| AID1898596 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. |
| AID163310 | Apparent dissociation constant of [3H]AMPA from quisqualate receptor of rat cortical slice | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID31606 | Binding affinity against AMPA receptor in rat brain membrane using [3H]-AMPA as radioligand | 1994 | Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
| 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor. |
| AID496834 | Displacement of [3H]AMPA from AMPA receptor in rat cortical membrane | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15
| alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside. |
| AID144896 | Inhibition of [3H]glycine binding to glycine site of N-methyl-D-aspartate glutamate receptor in rat cortical membranes | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID147418 | Binding affinity against rat brain Non N-methyl-D-aspartate glutamate receptor glutamate site expressed in Xenopus oocyte | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID143296 | Binding affinity towards rat brain NMDA receptor glycine site expressed in Xenopus oocyte | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID234072 | Selectivity for glycine site | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Synthesis and structure-activity relationships of substituted 1,4-dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors. |
| AID92343 | Binding affinity in rat brain cortical membranes by the displacement of [3H]AMPA at Ionotropic glutamate receptor AMPA | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors. |
| AID1898585 | Antischistosomal activity against Schistosoma mansoni Puerto-Rican schistosomula assessed as inhibition of parasite motility measured after 72 hrs | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. |
| AID1898595 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. |
| AID145182 | Apparent dissociation constant of [3H]glycine from N-methyl-D-aspartate glutamate receptor in rat cortical slice preparation | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID92776 | In vitro inhibition of the specific binding of [3H]AMPA to Ionotropic glutamate receptor AMPA in rat whole brain membranes in the presence of 100 uM KSCN | 1996 | Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
| Novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonists: synthesis and structure-activity relationships of 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and related compounds. |
| AID91453 | Apparent dissociation constant of [3H]kainate from Ionotropic glutamate receptor ionotropic kainate was determined in rat cortical slice preparation | 1991 | Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. |
| AID93561 | Displacement of [3H]kainate from rat brain cortical membrane Ionotropic glutamate receptor kainate | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors. |
| AID1898617 | Selectivity index, ratio of CC50 for human HepG2 cells measured after 72 hrs to EC50 for antischistosomal activity against Schistosoma mansoni Puerto-Rican schistosomula measured after 72 hrs | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. |
| AID1898586 | Antischistosomal activity against Schistosoma mansoni Puerto-Rican schistosomula assessed as phenotypic changes measured after 72 hrs | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. |
| AID1898618 | Selectivity index, ratio of CC50 for human HepG2 cells measured after 72 hrs to EC50 for antischistosomal activity against adult stage of Schistosoma mansoni measured after 72 hrs | 2021 | European journal of medicinal chemistry, Dec-15, Volume: 226 | Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |