Compounds > 6-n-aziridinyl-3-hydrox-7-methyl-2,3-dihydro-1h-pyrrolo(1,2-a)benzimidazole-5,8-dione 3-acetate
Page last updated: 2024-12-07

6-n-aziridinyl-3-hydrox-7-methyl-2,3-dihydro-1h-pyrrolo(1,2-a)benzimidazole-5,8-dione 3-acetate

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Description

6-N-aziridinyl-3-hydrox-7-methyl-2,3-dihydro-1H-pyrrolo(1,2-a)benzimidazole-5,8-dione 3-acetate: RN & structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID129997
CHEMBL ID447524
MeSH IDM0193673

Synonyms (9)

Synonym
1h-pyrrolo(1,2-a)benzimidazol-3-ol, 2,3,5,8-tetrahydro-6-(1-aziridinyl)-5,8-dioxo-7-methyl-, acetate (ester)
brn 3628636
6-n-aziridinyl-3-hydrox-7-methyl-2,3-dihydro-1h-pyrrolo(1,2-a)benzimidazole-5,8-dione 3-acetate
CHEMBL447524
[6-(aziridin-1-yl)-7-methyl-5,8-dioxo-2,3-dihydro-1h-pyrrolo[1,2-a]benzimidazol-3-yl] acetate
pbi-a
123567-24-8
DTXSID50924540
6-(aziridin-1-yl)-7-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1h-pyrrolo[1,2-a]benzimidazol-3-yl acetate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (83)

Assay IDTitleYearJournalArticle
AID151498Inhibitory activity against ovarian cancer cell line.1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID212883Lethal concentration against ovarian cancer cells expressed as logarithm value1997Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9
Studies of pyrrolo[1,2-alpha]benzimidazolequinone DT-diaphorase substrate activity, topoisomerase II inhibition activity, and DNA reductive alkylation.
AID46749concentration to inhibit 50%cancer cell growth and the value is the mean value which was obtained from 60 cancer cell line assay1996Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
Chemistry of the pyrrolo[1,2-alpha]benzimidazole antitumor agents: influence of the 7-substituent on the ability to alkylate DNA and inhibit topoisomerase II.
AID195057Ratio of catalytic rate to that of Michaelis-Menten constant (DT-diaphorase substrate activity)1997Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9
Studies of pyrrolo[1,2-alpha]benzimidazolequinone DT-diaphorase substrate activity, topoisomerase II inhibition activity, and DNA reductive alkylation.
AID81512Tested for cytotoxic activity against non-small cell lung cancer HOP-62 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID154634Lethal concentration in correlation with E09 was tested at a concentration of 10 e-41994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
A comparison of the cytotoxic and physical properties of aziridinyl quinone derivatives based on the pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]indole ring systems.
AID91255Dose-Response relationship for DNA single-strand cleavage with the compound in human 8226 multiple myeloma cells at a concentration of 0.1 ug/mL x1 hr.1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID201848Tested for cytotoxic activity against colon cancer SW-620 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID154631The highest concentration employed in the cytotoxicity assay was reported1994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
A comparison of the cytotoxic and physical properties of aziridinyl quinone derivatives based on the pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]indole ring systems.
AID102558Antitumor activity against MALME-3M cell line1994Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1
Structure-activity studies of benzimidazole-based DNA-cleaving agents. Comparison of benzimidazole, pyrrolobenzimidazole, and tetrahydropyridobenzimidazole analogues.
AID3023In vitro inhibition of 2008/R ovarian cancer cell line1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID154633Total growth inhibitory concentration in correlation with E09 was tested at a concentration of 10 e-41994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
A comparison of the cytotoxic and physical properties of aziridinyl quinone derivatives based on the pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]indole ring systems.
AID42720Tested for cytotoxic activity against renal cancer CAKI-1 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID46747Concentration required for 50% lethality, evaluated on 60 different cancer cell line screens1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Pyrrolo[1,2-a]benzimidazole-based quinones and iminoquinones. The role of the 3-substituent on cytotoxicity.
AID143344Tested for cytotoxic activity against non-small cell lung cancer NCI-H522 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID94882Tested for cytotoxic activity against colon cancer KM20L2 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID154635Total growth inhibitory concentration in correlation with E09 was tested at a concentration of 10 e-41994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
A comparison of the cytotoxic and physical properties of aziridinyl quinone derivatives based on the pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]indole ring systems.
AID167420Tested for cytotoxic activity against renal cancer RXF-393 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID46750The concentration to cause 50% cancer cell lethality and the value is the mean value which was obtained from 60 cancer cell line assay1996Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
Chemistry of the pyrrolo[1,2-alpha]benzimidazole antitumor agents: influence of the 7-substituent on the ability to alkylate DNA and inhibit topoisomerase II.
AID212882Lethal concentration against melanoma cells expressed as logarithm value1997Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9
Studies of pyrrolo[1,2-alpha]benzimidazolequinone DT-diaphorase substrate activity, topoisomerase II inhibition activity, and DNA reductive alkylation.
AID154632Growth inhibitory concentration in correlation with E09 was tested at a concentration of 10 e-41994Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
A comparison of the cytotoxic and physical properties of aziridinyl quinone derivatives based on the pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]indole ring systems.
AID202169Tested for cytotoxic activity against melanoma SK-MEL-5 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID7026In vitro inhibition of 7226/S myeloma cancer cell line1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID10028Tested for cytotoxic activity against renal cancer ACHN cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID9277Tested for cytotoxic activity against non-small cell lung cancer A549/ATCC cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID102552Tested for cytotoxic activity against melanoma MALME-3M cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID53912Tested for cytotoxic activity against colon cancer DLD-1 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID200482Tested for cytotoxic activity against CNS cancer SNB-19 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID46291Tested for cytotoxic activity against colon cancer COLO 205 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID137948The compound was tested for its ability to get to the tumor site after subcutaneous administration [Score of 2 indicates that there is a percent T/C of 50 or < 50(tumor mass 50% or < the control)]1999Journal of medicinal chemistry, Aug-26, Volume: 42, Issue:17
Design of highly active analogues of the pyrrolo[1,2-a]benzimidazole antitumor agents.
AID144940Tested for cytotoxic activity against non-small cell lung cancer NCI-H226 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID96330Tested for cytotoxic activity against leukemia K-562 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID214239Tested for cytotoxic activity against CNS cancer U251 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID145771Tested for cytotoxic activity against ovarian cancer OVCAR-8 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID100566Antitumor activity against LOX IMV cell line1994Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1
Structure-activity studies of benzimidazole-based DNA-cleaving agents. Comparison of benzimidazole, pyrrolobenzimidazole, and tetrahydropyridobenzimidazole analogues.
AID195058Michaelis-Menten Constant was determined for rat liver DT-diaphorase substrate activity1997Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9
Studies of pyrrolo[1,2-alpha]benzimidazolequinone DT-diaphorase substrate activity, topoisomerase II inhibition activity, and DNA reductive alkylation.
AID101550Tested for cytotoxic activity against melanoma M19-MEL cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID215126Tested for cytotoxic activity against renal cancer UO-31 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID91257Dose-Response relationship for DNA single-strand cleavage with the compound in human 8226 multiple myeloma cells at a concentration of 10 ug/mL x1 hr1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID145739Tested for cytotoxic activity against ovarian cancer OVCAR-5 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID93652Tested for cytotoxic activity against ovarian cancer IGROVI cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID145057Tested for cytotoxic activity against non-small cell lung cancer NCI-H23 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID3214In vitro inhibition of 2780/DOX ovarian cancer cell line1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID41968Tested for cytotoxic activity against non-small cell lung cancer BKVX cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID7053Tested for cytotoxic activity against renal cancer 786-0 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID145599Tested for cytotoxic activity against ovarian cancer OVCAR-4 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID209384Tested for cytotoxic activity against renal cancer TK-10 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID201808Tested for cytotoxic activity against melanoma SK-MEL-2 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID43860Tested for cytotoxic activity against leukemia CCRF-CEM cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID200671Tested for cytotoxic activity against CNS cancer SNB-75 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID228945Mean log10 LC50 was determined1994Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1
Structure-activity studies of benzimidazole-based DNA-cleaving agents. Comparison of benzimidazole, pyrrolobenzimidazole, and tetrahydropyridobenzimidazole analogues.
AID202175Antitumor activity against SK-MEL-5 cell line1994Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1
Structure-activity studies of benzimidazole-based DNA-cleaving agents. Comparison of benzimidazole, pyrrolobenzimidazole, and tetrahydropyridobenzimidazole analogues.
AID195067Maximum velocity was determined for rat liver DT diaphorase substrate activity1997Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9
Studies of pyrrolo[1,2-alpha]benzimidazolequinone DT-diaphorase substrate activity, topoisomerase II inhibition activity, and DNA reductive alkylation.
AID105480Tested for cytotoxic activity against leukemia MOLT-4 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID54100Tested for cytotoxic activity against small cell lung cancer DMS114 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID214591Tested for cytotoxic activity against melanoma UACC-257 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID81353Tested for cytotoxic activity against non-small cell lung cancer HOP-18 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID202213In vitro inhibition of SW480 colon cancer cell line1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID147798Tested for cytotoxic activity against ovarian cancer OVCAR -3 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID94701Tested for cytotoxic activity against colon cancer KM-12 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID200835Tested for cytotoxic activity against CNS cancer SP-295 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID3025In vitro inhibition of 2008/S ovarian cancer cell line1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID216610In vitro inhibition of WiDr colon cancer cell line1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID101522Tested for cytotoxic activity against melanoma M14 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID84361Tested for cytotoxic activity against non-small cell lung cancer HOP92 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID200808Tested for cytotoxic activity against CNS cancer SNB-78 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID214759Tested for cytotoxic activity against melanoma UACC-62 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID83773Tested for cytotoxic activity against colon cancer HT-29 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID202511Tested for cytotoxic activity against ovarian cancer SK-OV-3 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID91256Dose-Response relationship for DNA single-strand cleavage with the compound in human 8226 multiple myeloma cells at a concentration of 1.0 ug/mL x1 hr1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID219592Tested for cytotoxic activity against CNS cancer XF498 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID145186Tested for cytotoxic activity against non-small cell lung cancer NCI-H322M cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID46751concentration to inhibit 100%cancer cell growth and the value is the mean value which was obtained from 60 cancer cell line assay1996Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
Chemistry of the pyrrolo[1,2-alpha]benzimidazole antitumor agents: influence of the 7-substituent on the ability to alkylate DNA and inhibit topoisomerase II.
AID200465Tested for cytotoxic activity against renal cancer SN12C cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID3215In vitro inhibition of 2780/S ovarian cancer cell line1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID100713Tested for cytotoxic activity against melanoma LOX MVI cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID99211Tested for cytotoxic activity against non-small cell lung cancer LXFL-529L cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID134047The compound was tested for its ability to get to the tumor site after indicates that there is a percent T/C of 50 or < 50(tumor mass 50% or < the control)]1999Journal of medicinal chemistry, Aug-26, Volume: 42, Issue:17
Design of highly active analogues of the pyrrolo[1,2-a]benzimidazole antitumor agents.
AID230731Ratio of the LC50 value to that of PBI-A.1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Pyrrolo[1,2-a]benzimidazole-based quinones and iminoquinones. The role of the 3-substituent on cytotoxicity.
AID201963Tested for cytotoxic activity against melanoma SK-MEL-281993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID151499Inhibitory activity against ovarian cancer cell line; NA= Not achievable1991Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents.
AID200836Tested for cytotoxic activity against CNS cancer SP-539 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
AID200834Tested for cytotoxic activity against CNS cancer SP-268 cell line1993Journal of medicinal chemistry, Oct-15, Volume: 36, Issue:21
Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (88.89)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.05 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbazilquinone
Carbazilquinone: An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients.		3.110organic molecular entity
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		3.4920mitomycinalkylating agent;
antineoplastic agent
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		1.9710pyrrole;
secondary amine
diaziquone
diaziquone: RN given refers to parent cpd. diaziquone : A 1,4-benzoquinone that is substituted at positions 2 and 5 have been replaced by aziridin-1-yl groups and at positions 3 and 6 by (ethoxycarbonyl)amino groups.		3.1101,4-benzoquinones;
aziridines;
carbamate ester;
enamine		alkylating agent;
antineoplastic agent
2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone
2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone: structure given in first source		3.110
apaziquone
apaziquone: structure given in first source; RN given refers to (E)-isomer		3.110indoles
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		01.9710
Kahler Disease
[description not available]		01.9710
Cancer of Ovary
[description not available]		01.9710
Colonic Neoplasms
Tumors or cancer of the COLON.		01.9710
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.		01.9710
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		01.9710
Leucocythaemia
[description not available]		01.9810
Malignant Melanoma
[description not available]		01.9810
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		01.9810
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		01.9810