Compounds > 6-hydroxybuspirone
Page last updated: 2024-11-12

6-hydroxybuspirone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

6-hydroxybuspirone: active metabolite of buspirone [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9930913
CHEMBL ID1201371
CHEBI ID192155
MeSH IDM0506361

Synonyms (29)

Synonym
bmy 28674
6'-hydroxy buspirone
bmy 28674-d8
FT-0669440
125481-61-0
6-hydroxy buspirone
10-hydroxy-8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
CHEBI:192155
CHEMBL1201371
6-hydroxybuspirone
6-hydroxy-buspirone
KOZNAHJIJGCFJJ-UHFFFAOYSA-N
DTXSID00433011
6-hydroxy-8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-8-azaspiro(4.5)decane-7,9-dione
J-005232
6'-hydroxy-buspirone
unii-4pri09e14u
6'-hydroxybuspirone
6-hydroxy-8- (4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-8-azaspiro(4.5)decane-7,9-dione
bms-528215
4pri09e14u ,
AKOS030255500
FT-0669441
6-hydroxybuspirone; 6'-hydroxybuspirone; bms 528215
8-azaspiro[4.5]decane-7,9-dione, 6-hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-
Q27260341
6-hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9- dione
PD121389
EX-A8006G

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
"3 l/kg), and half-life (1."( 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.
Dockens, RC; Grace, JE; Li, YW; Pajor, L; Stark, AD; Taub, RA; Wong, H; Yeola, S; Yocca, FD; Zaczek, RC, 2007)		1.78

Bioavailability

ExcerptReferenceRelevance
" Bioavailability was higher for 6-OH-buspirone (19%) compared with that for buspirone (1."( 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.
Dockens, RC; Grace, JE; Li, YW; Pajor, L; Stark, AD; Taub, RA; Wong, H; Yeola, S; Yocca, FD; Zaczek, RC, 2007)		1.78
" By examination of absorption curves derived by Wagner-Nelson analysis of pharmacokinetic data it was noted that drug release in vivo correlated well with drug release observed in vitro and no marked change in rate of absorption was noted when dosage forms were located in and releasing drug in the colon."( Development of oral extended release formulations of 6-hydroxybuspirone.
Connor, A; Croop, R; Dennis, AB; Dockens, RC; Ferrie, P; Nicholson, SJ; Timmins, P; Wilding, I; Zeng, J, 2012)		0.63

Dosage Studied

ExcerptRelevanceReference
" Oral dosing of buspirone in rats resulted in exposures (area under the concentration-time profile) of 6-OH-buspirone and 1-(2-pyrimidinyl)-piperazine (1-PP), another major metabolite of buspirone, that were approximately 12 (6-OH-buspirone)- and 49 (1-PP)-fold higher than the exposure of the parent compound."( 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.
Dockens, RC; Grace, JE; Li, YW; Pajor, L; Stark, AD; Taub, RA; Wong, H; Yeola, S; Yocca, FD; Zaczek, RC, 2007)		1.78
" There was a 4-day washout between each dosing period."( Pharmacokinetics of 6-hydroxybuspirone and its enantiomers administered individually or following buspirone administration in humans.
Croop, R; Dockens, RC; Tran, AQ; Zeng, J, 2007)		0.66
" This observation, along with a desire to provide for once daily dosing of this compound, provided the basis for the development of an extended release formulation."( Development of oral extended release formulations of 6-hydroxybuspirone.
Connor, A; Croop, R; Dennis, AB; Dockens, RC; Ferrie, P; Nicholson, SJ; Timmins, P; Wilding, I; Zeng, J, 2012)		0.63
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
N-arylpiperazine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.21 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.21)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (50.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other3 (50.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
citric acid, anhydrous
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.. citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.		3.4611tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
buspirone
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.. buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.		5.6163azaspiro compound;
N-alkylpiperazine;
N-arylpiperazine;
organic heteropolycyclic compound;
piperidones;
pyrimidines		anxiolytic drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
sedative;
serotonergic agonist
kampirone
1-(2-pyrimidinyl)piperazine: metabolite of buspirone; structure given in first source		2.4920N-arylpiperazine
1-(2-pyridinyl)piperazine
1-(2-pyridinyl)piperazine: metabolite of buspirone & gepirone		2.0310
methylcellulose
Methylcellulose: Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.		3.4611
aconitine
Aconitine: A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties.. aconitine : A diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively.		2.4920
ConditionIndicatedRelationship StrengthStudiesTrials