6-azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 11334126 |
| CHEMBL ID | 506543 |
| MeSH ID | M0477426 |
| Synonym |
|---|
| 6-azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione |
| bdbm50253632 |
| CHEMBL506543 , |
| ZSUXPQBYUUWJJN-UHFFFAOYSA-N |
| 6-azido-2,3-dihydroxy-7-nitroquinoxaline |
| 6-azido-7-nitro-1,2,3,4-tetrahydroquinoxaline-2,3-dione |
| EN300-45411689 |
| PD135990 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 2 | Homo sapiens (human) | IC50 (µMol) | 1.0000 | 0.0190 | 1.6403 | 5.5000 | AID364455 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| signal transduction | Glutamate receptor 2 | Homo sapiens (human) |
| chemical synaptic transmission | Glutamate receptor 2 | Homo sapiens (human) |
| ionotropic glutamate receptor signaling pathway | Glutamate receptor 2 | Homo sapiens (human) |
| synaptic transmission, glutamatergic | Glutamate receptor 2 | Homo sapiens (human) |
| regulation of postsynaptic membrane potential | Glutamate receptor 2 | Homo sapiens (human) |
| monoatomic cation transmembrane transport | Glutamate receptor 2 | Homo sapiens (human) |
| modulation of chemical synaptic transmission | Glutamate receptor 2 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| AMPA glutamate receptor activity | Glutamate receptor 2 | Homo sapiens (human) |
| amyloid-beta binding | Glutamate receptor 2 | Homo sapiens (human) |
| glutamate-gated receptor activity | Glutamate receptor 2 | Homo sapiens (human) |
| AMPA glutamate receptor activity | Glutamate receptor 2 | Homo sapiens (human) |
| protein binding | Glutamate receptor 2 | Homo sapiens (human) |
| ligand-gated monoatomic cation channel activity | Glutamate receptor 2 | Homo sapiens (human) |
| transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | Glutamate receptor 2 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID364455 | Inhibition of GluR2 receptor | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18 | 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (16.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||