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6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine

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Description

6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine: inhibits oxidized low-density lipoprotein induced apoptosis in human umbilical vein endothelial cell; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25054598
CHEMBL ID382894
SCHEMBL ID2596751
MeSH IDM0536889

Synonyms (11)

Synonym
CHEMBL382894
(6-amino-3,4-dihydro-2h-1,4-benzoxazin-3-yl)methanol
SCHEMBL2596751
QULMQWMDJWXOMS-UHFFFAOYSA-N
2,3-dihydro-3-hydroxymethyl-6-amino-[1,4]-benzoxazine
AKOS024016429
896126-03-7
6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine
6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine
EN300-172629
abo (hydrochloride)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID426643Antiapoptotic activity against low density lipoprotein-induced apoptosis in HUVEC cells assessed as nuclear fragmentation after 24 hrs by acridin orange staining2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
AID426644Antiapoptotic activity against low density lipoprotein-induced apoptosis in HUVEC cells assessed as apoptotic cell after 24 hrs by TUNEL assay2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
AID265053Inhibition of HUVEC cell line apoptosis at 50 uM2006Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
Design, synthesis, and preliminary biological evaluation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives.
AID426646Antiapoptotic activity against low density lipoprotein-induced vascular apoptosis in HUVEC cells assessed as inhibition of ROS by lase scanning confocal microscope2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
AID265054Inhibition of HUVEC cell line apoptosis at 100 uM2006Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
Design, synthesis, and preliminary biological evaluation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives.
AID426650Cytotoxicity against HUVEC cells assessed as reduction in low density lipoprotein-induced cell viability at 50 uM by MTT assay2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
AID426648Antiapoptotic activity against low density lipoprotein-induced vascular apoptosis in HUVEC cells assessed as translocation of NF-kappaB across the nucleus by lase scanning confocal microscope2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
AID265064Antiproliferative activity against human A549 cell line by MTT assay2006Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
Design, synthesis, and preliminary biological evaluation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives.
AID426642Antiapoptotic activity against low density lipoprotein-induced apoptosis in HUVEC cells by Hoechst 33258 staining2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
AID426641Antiapoptotic activity against low density lipoprotein-induced apoptosis in HUVEC cells assessed as nuclear condensation after 24 hrs by acridin orange staining2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
AID426645Antiapoptotic activity against low density lipoprotein-induced apoptosis in HUVEC cells assessed as inhibition of integrin beta4 level at 50 uM by immunofluorescence technique2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
AID426649Antiapoptotic activity against low density lipoprotein-induced vascular apoptosis in HUVEC cells assessed as modulation of P53 level by lase scanning confocal microscope2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
AID265055Inhibition of HUVEC cell line apoptosis at 200 uM2006Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
Design, synthesis, and preliminary biological evaluation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives.
AID426647Antiapoptotic activity against low density lipoprotein-induced vascular apoptosis in HUVEC cells assessed as modulation of NF-kappaB level by lase scanning confocal microscope2009Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's10 (83.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.04 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.60 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]