Compounds > 6-amino-1,2-benzopyrone
Page last updated: 2024-12-06

6-amino-1,2-benzopyrone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

6-Amino-1,2-benzopyrone, also known as 6-amino-coumarin, is a synthetic derivative of coumarin. It has been investigated for its potential biological activities, including antibacterial, antifungal, and anticancer properties. Research suggests that its effects might stem from its ability to inhibit enzyme activity and influence cellular processes. Further studies are necessary to fully elucidate its mechanisms of action and potential therapeutic applications.'

6-amino-1,2-benzopyrone: selective inhibitor of adenosine diphosphoribosyl transferase; RN given refers to the parent compound [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID46153
CHEMBL ID1829962
SCHEMBL ID483027
MeSH IDM0184980

Synonyms (33)

Synonym
HMS1749K04
BB 0245754
6-amino-2h-1-benzopyran-2-one
6-amino-chromen-2-one
OPREA1_467607
OPREA1_644760
nsc613801
6-amino-1,2-benzopyrone
coumarin, 6-amino-
6-abp
6-aminocoumarin
6-aminochromen-2-one
2h-1-benzopyran-2-one, 6-amino-
6-amino-2h-chromen-2-one
STK140470
AKOS000111175
(2-oxochromen-6-yl)azanium chloride
CHEMBL1829962
14415-44-2
EN300-51130
unii-s9w3l9r2na
s9w3l9r2na ,
FT-0684448
SCHEMBL483027
6-amino-2h-chromen-2-one #
4jq ,
DTXSID70162624
mfcd00115435
6-amino-chromen-2-one, aldrichcpr
Z56754502
CS-0207101
AS-42838
Q27454762
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID619823Vasorelaxant activity in Wistar rat thoracic aortic ring assessed as inhibition of norepinephrine hydrochloride-induced contraction treated after noradrenaline challenge2011Bioorganic & medicinal chemistry, Oct-15, Volume: 19, Issue:20
Design, synthesis and vasorelaxant evaluation of novel coumarin-pyrimidine hybrids.
AID619824Aqueous solubility, log S of the compound2011Bioorganic & medicinal chemistry, Oct-15, Volume: 19, Issue:20
Design, synthesis and vasorelaxant evaluation of novel coumarin-pyrimidine hybrids.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (23.08)18.2507
2000's1 (7.69)29.6817
2010's8 (61.54)24.3611
2020's1 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.16 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index5.00 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzamide
benzamide : An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.		1.9710benzamides
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.		210ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
ether
Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.. ether : An organooxygen compound with formula ROR, where R is not hydrogen.. diethyl ether : An ether in which the oxygen atom is linked to two ethyl groups.		2.610ether;
volatile organic compound		inhalation anaesthetic;
non-polar solvent;
refrigerant
prazosin
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.. prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.		2.0610aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
salicylaldehyde
o-hydroxybenzaldehyde: structure in first source		2.0810hydroxybenzaldehydenematicide;
plant metabolite
1-chloropropane
1-chloropropane: structure in first source		2.110
1-nitrobenzo(a)pyrene
[no description available]		210
3-nitrobenzo(a)pyrene
[no description available]		210
5-iodo-6-amino-1,2-benzopyrone
[no description available]		6.9710
7-aminocoumarin
7-amino coumarin: structure in first source		2.0610
aluminum
Aluminum: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.		2.0810boron group element atom;
elemental aluminium;
metal atom
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		3.73100benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Abnormalities, Autosome
[description not available]		0210