6,2',4'-trimethoxyflavone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

6,2',4'-trimethoxyflavone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	688802
SCHEMBL ID	4915794
MeSH ID	M0542982

Synonyms (22)

Synonym
6,2',4'-trimethoxyflavone
2-(2,4-dimethoxyphenyl)-6-methoxychromen-4-one
ST057638
720675-90-1
2-(2,4-dimethoxyphenyl)-2,3-dihydro-6-methoxy-4h-1-benzopyran-4-one
flavonid, 6[4,2]
bdbm93448
720675-74-1
SCHEMBL4915794
AKOS024282698
2',4',6-trimethoxyflavone
4h-1-benzopyran-4-one, 2-(2,4-dimethoxyphenyl)-6-methoxy-
WUWFDVDASNSUKP-UHFFFAOYSA-N
mfcd03412381
2-(2,4-dimethoxyphenyl)-6-methoxy-4h-chromen-4-one
DTXSID80350974
6, 2', 4'-trimethoxyflavone, >=98% (hplc)
FT-0750678
MS-24550
HY-103220
CS-0025311
PD001171

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Cathepsin L2	Homo sapiens (human)	IC50 (µMol)	50.0000	0.0750	2.2141	10.0000	AID1799911
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (7)

Process	via Protein(s)	Taxonomy
apoptotic process	Cathepsin L2	Homo sapiens (human)
antigen processing and presentation of exogenous peptide antigen via MHC class II	Cathepsin L2	Homo sapiens (human)
extracellular matrix disassembly	Cathepsin L2	Homo sapiens (human)
immune response	Cathepsin L2	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Cathepsin L2	Homo sapiens (human)
positive regulation of peptidase activity	Cathepsin L2	Homo sapiens (human)
proteolysis involved in protein catabolic process	Cathepsin L2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Process	via Protein(s)	Taxonomy
cysteine-type endopeptidase activity	Cathepsin L2	Homo sapiens (human)
serine-type endopeptidase activity	Cathepsin L2	Homo sapiens (human)
protein binding	Cathepsin L2	Homo sapiens (human)
cysteine-type peptidase activity	Cathepsin L2	Homo sapiens (human)
cysteine-type endopeptidase activator activity involved in apoptotic process	Cathepsin L2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Process	via Protein(s)	Taxonomy
extracellular region	Cathepsin L2	Homo sapiens (human)
lysosomal lumen	Cathepsin L2	Homo sapiens (human)
extracellular space	Cathepsin L2	Homo sapiens (human)
lysosome	Cathepsin L2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID1799911	Inhibition Activity Assay from Article 10.1021/cc100076k: \\Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors.\\	2010	Journal of combinatorial chemistry, Sep-13, Volume: 12, Issue:5	Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (100.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	17.86 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.63 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (17.86)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2.13	1	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
kynurenine Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.. kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.	2.52	2	aromatic ketone; non-proteinogenic alpha-amino acid; substituted aniline	human metabolite
benzo(a)pyrene Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.	2.05	1	ortho- and peri-fused polycyclic arene	carcinogenic agent; mouse metabolite
4-chlorobiphenyl 4-chlorobiphenyl : A monochlorobiphenyl carrying a chloro substituent at position 4.	2.11	1	monochlorobiphenyl
3,4,5,3',4'-pentachlorobiphenyl 3,3',4,4',5-pentachlorobiphenyl : A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.	2.11	1	pentachlorobiphenyl; trichlorobenzene
6-methoxy-2-(4-methoxyphenyl)-1-benzopyran-4-one [no description available]	2.05	1	ether; flavonoids

Condition	Relationship Strength	Studies
Cerebral Infarction, Middle Cerebral Artery [description not available]	2.1	1
Cerebral Ischemia [description not available]	2.1	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.1	1
Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.	2.1	1
Infarction, Middle Cerebral Artery NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.	2.1	1

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