Compounds > 5-oxo-1-(2-phenylethyl)-3-pyrrolidinecarboxylic acid
Page last updated: 2024-09-27

5-oxo-1-(2-phenylethyl)-3-pyrrolidinecarboxylic acid

Cross-References

ID SourceID
PubMed CID207650
CHEMBL ID1720704
CHEBI ID105784
SCHEMBL ID1263215

Synonyms (40)

Synonym
3-pyrrolidinecarboxylic acid, 5-oxo-1-(2-phenylethyl)-
brn 0220839
5-oxo-1-(2-phenylethyl)-3-pyrrolidinecarboxylic acid
BB 0240660
5-oxo-1-phenethyl-pyrrolidine-3-carboxylic acid
smr000150392
MLS000570337
CHEMDIV3_014417
EU-0066681
IDI1_030215
STK500673
5-oxo-1-(2-phenylethyl)pyrrolidine-3-carboxylic acid
AKOS000114239
HMS1513P07
5-oxo-1-phenethylpyrrolidine-3-carboxylic acid
NCGC00246164-01
5-22-06-00044 (beilstein handbook reference)
30380-70-2
5-oxo-1-phenethyl-pyrrolidine-3-carboxylic acid
EN300-08621
BBL011694
HMS2323C19
S12220
AKOS016042116
SCHEMBL1263215
AO-365/42983215
CHEMBL1720704
Q27183564
5-oxo-1-(2-phenylethyl)-pyrrolidine-3-carboxylic acid
J-517900
sr-01000103856
SR-01000103856-1
5-oxo-1-(2-phenylethyl)-3-pyrrolidinecarboxylic acid, aldrichcpr
mfcd00973748
CHEBI:105784
Z56968741
BS-11093
DTXSID90952726
5-oxo-1-(2-phenylethyl)pyrrolidine-3-carboxylicacid
F1904-0094

Drug Classes (2)

ClassDescription
carboxylic acidA carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
pyrrolidinecarboxylic acid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's6 (66.67)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
foscarnet[no description available]low00carboxylic acid;
one-carbon compound;
phosphonic acids		antiviral drug;
geroprotector;
HIV-1 reverse transcriptase inhibitor;
sodium-dependent Pi-transporter inhibitor
cephalothin[no description available]low00azabicycloalkene;
beta-lactam antibiotic allergen;
carboxylic acid;
cephalosporin;
semisynthetic derivative;
thiophenes		antibacterial drug;
antimicrobial agent
bromoacetate[no description available]low00carboxylic acid;
organohalogen compound
dalapon[no description available]low00carboxylic acid;
organohalogen compound
alpha-naphthylphthalamic acid[no description available]low00carboxylic acid;
dicarboxylic acid monoamide;
N-(1-naphthyl)carboxamide		herbicide
ethoxyacetic acid[no description available]low00carboxylic acid
diisopropylamine dichloroacetate[no description available]low00carboxylic acid;
organohalogen compound
2-phenoxypropanoic acid[no description available]low00aromatic ether;
carboxylic acid
mafenide acetate[no description available]low00carboxylic acid
n-butoxyacetic acid[no description available]low00carboxylic acid
cefazedone[no description available]low004-pyridones;
carboxylic acid;
cephalosporin;
semisynthetic derivative;
thiadiazoles		antibacterial drug
picaridin[no description available]low00carboxylic acid;
piperidines
als 8123[no description available]low00carboxylic acid;
ethanolamines;
secondary amino compound
aspartame[no description available]low00carboxylic acid;
dipeptide zwitterion;
dipeptide;
methyl ester		apoptosis inhibitor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
environmental contaminant;
micronutrient;
nutraceutical;
sweetening agent;
xenobiotic
2-(4-methoxyphenoxy)propanoic acid[no description available]low00aromatic ether;
carboxylic acid
alpha-fluoro-beta-ureidopropionic acid[no description available]low00carboxylic acid;
organohalogen compound
cefpiramide[no description available]low00carboxylic acid;
cephalosporin		antibacterial drug
4-(2-benzamidoethylamino)-1-piperidinecarboxylic acid ethyl ester[no description available]low00carboxylic acid;
piperidines
1-(4,6-dimethyl-2-pyrimidinyl)-4-piperidinecarboxylic acid[no description available]low00carboxylic acid;
piperidines
1-(1-oxo-2-thiophen-2-ylethyl)-4-piperidinecarboxylic acid ethyl ester[no description available]low00carboxylic acid;
piperidines
1-(3-phenylpropanoyl)-4-piperidinecarboxylic acid[no description available]low00carboxylic acid;
piperidines
1-[2-hydroxy-3-[4-(2-methylbutan-2-yl)phenoxy]propyl]-4-piperidinecarboxylic acid ethyl ester[no description available]low00carboxylic acid;
piperidines
1-[2-[(4-chlorophenyl)thio]-1-oxopropyl]-4-piperidinecarboxylic acid ethyl ester[no description available]low00carboxylic acid;
piperidines
1-[2-[3-(N-ethylanilino)propylamino]-3,4-dioxo-1-cyclobutenyl]-4-piperidinecarboxylic acid ethyl ester[no description available]low00carboxylic acid;
piperidines
4-[[2-(3-ethylanilino)-3,4-dioxo-1-cyclobutenyl]amino]-1-piperidinecarboxylic acid ethyl ester[no description available]low00carboxylic acid;
piperidines
1-[(6-hydroxy-2-methyl-5-thiazolo[3,2-b][1,2,4]triazolyl)-(3,4,5-trimethoxyphenyl)methyl]-4-piperidinecarboxylic acid methyl ester[no description available]low00carboxylic acid;
piperidines
rifamycin b[no description available]low00acetate ester;
carboxylic acid;
organic heterotetracyclic compound;
rifamycins
pradimicin a[no description available]low00aromatic ether;
carboxylic acid;
disaccharide derivative;
L-alanine derivative;
p-quinones;
polyphenol;
pradimicin;
secondary alcohol
cefpodoxime[no description available]low00carboxylic acid;
cephalosporin		antibacterial drug
cefatrizine[no description available]low00amino acid amide;
carboxylic acid;
cephalosporin;
phenols;
semisynthetic derivative;
triazoles		antibacterial drug;
EC 2.7.11.20 (elongation factor 2 kinase) inhibitor
s 1006[no description available]low001,3-thiazoles;
carbamate ester;
carboxylic acid;
cephalosporin;
enamide;
secondary carboxamide		antibacterial drug
cinalukast[no description available]low001,3-thiazoles;
carboxylic acid		anti-arrhythmia drug;
anti-asthmatic drug;
leukotriene antagonist
cefpodoxime proxetil[no description available]low00carboxylic acid;
carboxylic ester;
cephalosporin		antibacterial drug;
prodrug
u 62840[no description available]low00carbotricyclic compound;
carboxylic acid		antihypertensive agent;
cardiovascular drug;
human blood serum metabolite;
platelet aggregation inhibitor;
vasodilator agent;
vitamin K antagonist
cefditoren[no description available]low00carboxylic acid;
cephalosporin		antibacterial drug
tubulysin a[no description available]low00carboxylic acid;
diester
tubulysin d[no description available]low00carboxylic acid;
diester
4-[[3-(4-chlorophenyl)-5-isoxazolyl]methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-piperidinecarboxylic acid[no description available]low00carboxylic acid;
piperidines
ethyl 1-benzyl-3-hydroxy-2(5h)-oxopyrrole-4-carboxylate[no description available]low00carboxylic acid;
pyrroline
cefiderocol[no description available]low00carboxylic acid;
cephalosporin		antibacterial drug;
siderophore
kainic acid[no description available]low00dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
acromelic acid a[no description available]low00pyridone;
pyrrolidinecarboxylic acid;
tricarboxylic acid		fungal metabolite;
neurotoxin;
NMDA receptor agonist
2,2,5,5-tetramethyl-1-pyrrolidinyloxy-3-carboxylic acid[no description available]low00aminoxyls;
pyrrolidinecarboxylic acid
spiraprilat[no description available]low00azaspiro compound;
dicarboxylic acid;
dipeptide;
dithioketal;
pyrrolidinecarboxylic acid;
secondary amino compound;
tertiary carboxamide		antihypertensive agent;
drug metabolite;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
domoic acid[no description available]low00L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid;
tricarboxylic acid		algal metabolite;
hapten;
marine metabolite;
neuromuscular agent;
neurotoxin
spirapril[no description available]low00azaspiro compound;
dicarboxylic acid monoester;
dipeptide;
dithioketal;
ethyl ester;
pyrrolidinecarboxylic acid;
secondary amino compound;
tertiary carboxamide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
prodrug
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio0low10
Epidemic Acute Poliomyelitis0low10
Infantile Paralysis0low10
Inflammation0low10
Innate Inflammatory Response0low10
Malaria, Falciparum0low10
Plasmodium falciparum Malaria0low10
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10