5-nitro-2'-deoxyuridine 5'-monophosphate profile

Cross-References

ID Source	ID
PubMed CID	149015
CHEMBL ID	1234672
SCHEMBL ID	9590644
MeSH ID	M0068415

Synonyms (18)

Synonym
5'-uridylic acid, 2'-deoxy-5-nitro-
unii-m5xxz2mq75
m5xxz2mq75 ,
63689-79-2
5-nitro-2'-deoxyuridine 5'-monophosphate
CHEMBL1234672 ,
NDN ,
2'-deoxy-5-nitrouridine 5'-(dihydrogen phosphate)
5-nitro-2'-deoxyuridylate
[(2r,3s,5r)-3-hydroxy-5-(5-nitro-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
SCHEMBL9590644
bdbm50010241
DTXSID30213085
5-nitro-2'-deoxyuridylic acid
5-nitrodeoxyuridylic acid
Q27463760
Q27283526
PD195095

Protein Targets (4)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Thymidylate synthase	Lacticaseibacillus casei	Ki	0.0290	0.0100	1.6550	9.3900	AID1134942
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.0290	0.0000	0.6068	9.2330	AID1134942
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.0290	0.0000	0.3845	8.6000	AID1134942
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.0290	0.0000	0.1868	3.9500	AID1134942
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID1134942	Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by radioisotope assay	1979	Journal of medicinal chemistry, Sep, Volume: 22, Issue:9	5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (85.71)	18.7374
1990's	1 (14.29)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.21 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.29 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.21)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
thymidine [no description available]	1.95	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
bromodeoxyuridine Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.	1.95	1	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent
fluorodeoxyuridylate Fluorodeoxyuridylate: 5-Fluoro-2'-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine.	2.36	2	pyrimidine 2'-deoxyribonucleoside 5'-monophosphate
deoxyuridine [no description available]	6.95	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
bromodeoxyuridylate bromodeoxyuridylate: RN given refers to parent cpd	2.36	2
5-nitro-2'-deoxyuridine [no description available]	6.95	1
5-trifluoromethyl-2'-deoxyuridylic acid [no description available]	1.95	1
5-iodo-2'-deoxyuridine 5'-monophosphate iododeoxyuridylate: RN given refers to parent cpd	1.95	1
5-chloro-2'-deoxyuridine 5'-triphosphate [no description available]	1.95	1

5-nitro-2'-deoxyuridine 5'-monophosphate