Page last updated: 2024-11-12

5-hydroxyflunixin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-hydroxyflunixin: drug residue in cow milk [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID12978215
MeSH IDM0536461

Synonyms (16)

Synonym
FT-0669638
75369-61-8
5-hydroxy flunixin (contain 5% flunixin)
5-hydroxyflunixin
5-hydroxy-2-(2-methyl-3-trifluoromethylanilino) nicotinic acid
5-hydroxy-2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
DTXSID60514274
5-hydroxy flunixin
5-hydroxyflunixin, vetranal(tm), analytical standard
AKOS030242943
Q63409161
5-hydroxy-2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinic acid
flunixin-5-hydroxy 100 microg/ml in acetonitrile
5-hydroxy flunixin is known as a flunixin metabolite.
PD150652
5-hydroxy-2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinicacid

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" For FLU plasma samples, a difference in terminal half-life was observed among routes of administration."( Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle.
Baynes, RE; Kissell, LW; Leavens, TL; Riviere, JE; Smith, GW; Wu, H, 2012
)
0.38
" Within-drug and metabolite analysis of pharmacokinetic parameters included fixed effects of drug administration date, sex and breed of sire."( The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine.
Ashwell, MS; Baynes, RE; Bellis, B; Brooks, JD; Howard, JT; Maltecca, C; O'Nan, AT; Routh, P; Yeatts, JL, 2014
)
0.4
" The geometric mean terminal half-life was 20."( Short communication: Determination of the milk pharmacokinetics and depletion of milk residues of flunixin following transdermal administration to lactating Holstein cows.
Coetzee, JF; Gorden, PJ; Kleinhenz, MD; Sidhu, PK; Warner, R, 2019
)
0.51

Bioavailability

ExcerptReferenceRelevance
" The mean bioavailability following intramuscular and subcutaneous dosing was 84."( Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle.
Baynes, RE; Kissell, LW; Leavens, TL; Riviere, JE; Smith, GW; Wu, H, 2012
)
0.38

Dosage Studied

ExcerptRelevanceReference
" The milk was collected 12h after dosing from cows which received meloxicam (0."( In-house reference materials: 5-hydroxyflunixin and meloxicam in cow milk-preparation and evaluation.
Jedziniak, P; Olejnik, M; Szprengier-Juszkiewicz, T, 2009
)
0.64
" The mean bioavailability following intramuscular and subcutaneous dosing was 84."( Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle.
Baynes, RE; Kissell, LW; Leavens, TL; Riviere, JE; Smith, GW; Wu, H, 2012
)
0.38
" The highest flunixin concentration in milk was observed 12 h after dosing (2."( Identification of flunixin glucuronide and depletion of flunixin and its marker residue in bovine milk.
Jedziniak, P; Kaczmarowski, M; Olejnik, M; Smulski, S; Szprengier-Juszkiewicz, T; Żmudzki, J, 2013
)
0.39
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's7 (70.00)24.3611
2020's2 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.98 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.55 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.98)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (20.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]