Page last updated: 2024-12-07

5-hydroxy-2-oxindole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-Hydroxy-2-oxindole is a heterocyclic compound with potential biological activity. It has been investigated for its antioxidant and anti-inflammatory properties, as well as its potential role in inhibiting the growth of cancer cells. Notably, it has been found to be an effective inhibitor of the enzyme indoleamine 2,3-dioxygenase (IDO), which is involved in the immune response and has been implicated in various diseases, including cancer and autoimmune disorders. The compound's synthesis typically involves the use of organic chemistry reactions such as Friedel-Crafts acylation and reduction. The research into 5-hydroxy-2-oxindole aims to elucidate its mechanism of action, explore its therapeutic potential, and optimize its properties for future drug development.'

5-hydroxyoxindole: Monoamine Oxidase Inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID76955
CHEMBL ID3093623
SCHEMBL ID19391
MeSH IDM0438191

Synonyms (39)

Synonym
AC-1914
5-hydroxy-1,3-dihydro-2h-indol-2-one
2,3-dihydro-5-hydroxyindol-2-one
einecs 222-309-1
5-hydroxyoxindole
H-7065
5-hydroxy-1,3-dihydro-indol-2-one
3416-18-0
5-hydroxy-1,3-dihydroindol-2-one
AR-683/41718240
A6024
5-hydroxyindolin-2-one
AKOS005258613
5-hydroxy-2-oxyindole
AM803729
FT-0601082
SCHEMBL19391
CHEMBL3093623
5-hydroxy-oxindole
5-hydroxyindolinone
5-hydroxy-2-oxindole
2h-indol-2-one, 1,3-dihydro-5-hydroxy-
2-indolinone, 5-hydroxy-
5-hydroxy-1,3-dihydro-2h-indol-2-one #
5-hydroxy-2-indolinone
5-hydroxyoxindole, aldrichcpr
mfcd00014566
DTXSID20187761
CS-W001542
5-hydroxy-2,3-dihydro-1h-indol-2-one
GS-3807
BCP27895
SB64276
EN300-177590
HY-W001542
PD171601
SY031204
EX-A7998G
Z1198147431
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1058624Octanol-water partition coefficient, logKOW of the compound2013Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
Antioxidant activities of 5-hydroxyoxindole and its 3-hydroxy-3-phenacyl derivatives: the suppression of lipid peroxidation and intracellular oxidative stress.
AID1058623Antioxidant activity in human HL60 cells assessed as reduction of H2O2-induced intracellular oxidative stress at 10 uM after 1 hr using DCFH-DA by FACS analysis2013Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
Antioxidant activities of 5-hydroxyoxindole and its 3-hydroxy-3-phenacyl derivatives: the suppression of lipid peroxidation and intracellular oxidative stress.
AID1058622Cytotoxicity against human HL60 cells assessed as reduction of cell viability at 100 uM after 24 hrs by trypan blue dye exclusion test2013Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
Antioxidant activities of 5-hydroxyoxindole and its 3-hydroxy-3-phenacyl derivatives: the suppression of lipid peroxidation and intracellular oxidative stress.
AID1058626Antioxidant activity assessed as DPPH free radical scavenging activity by spectroscopic analysis2013Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
Antioxidant activities of 5-hydroxyoxindole and its 3-hydroxy-3-phenacyl derivatives: the suppression of lipid peroxidation and intracellular oxidative stress.
AID1058625Antioxidant activity against tert-butylhydroperoxide-induced lipid peroxidation in rat liver microsomes after 20 mins by TBARS method2013Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
Antioxidant activities of 5-hydroxyoxindole and its 3-hydroxy-3-phenacyl derivatives: the suppression of lipid peroxidation and intracellular oxidative stress.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.43 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]