Compounds > 5-hydroxy-1-methyl-2-(di-n-propylamino)tetralin
Page last updated: 2024-11-07

5-hydroxy-1-methyl-2-(di-n-propylamino)tetralin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-hydroxy-1-methyl-2-(di-n-propylamino)tetralin: RN given refers to cis-isomer; RN not in Chemline 9/85; RN and structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID125884
CHEMBL ID346239
SCHEMBL ID9309477
MeSH IDM0133415

Synonyms (9)

Synonym
uh 242
CHEMBL346239
96148-66-2
5-oh-mdat
1-naphthalenol, 6-(dipropylamino)-5,6,7,8-tetrahydro-5-methyl-, (5r-cis)-
5-hmdpt
5-hydroxy-1-methyl-2-(di-n-propylamino)tetralin
SCHEMBL9309477
cis-5-hydroxy-1-methyl-2-(di-n-propylamino)tetralin
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID169396Locomotory activity was determined in non pretreated rats at a dose of 3.2 umol/kg by subcutaneous administration1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
AID62585Ability to displace the DA receptor agonist DiPr-5,6-ADTN from rat striatal binding sites in vivo at a dose of 40 uM/kg by subcutaneous administration1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
AID169394Locomotory activity was determined in non pretreated rats at a dose of 13.4 umol/kg by subcutaneous administration1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
AID171008Change in rectal temperature induced by DiPr-5,6-ADTN at a dose of 10 umol/kg of compound by subcutaneous administration1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
AID176767In vivo DOPA accumulation in non pre-treated rat striatal system following s.c. administration.1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
AID176776In vivo DOPA accumulation in reserpine pretreated rat limbic system by subcutaneous administration1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
AID62586Ability to displace the Dopamine receptor agonist DiPr-5,6-ADTN from rat striatal binding sites in vivo at a dose of 10 uM/kg by subcutaneous administration1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
AID176781In vivo DOPA accumulation in reserpine pretreated rat striatum system by subcutaneous administration1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
AID169405Locomotory activity was determined in reserpine pretreated rats at a dose of 3.2 umol/kg by subcutaneous administration. Value is the accumulation counts/30 min1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
AID171014Change in rectal temperature induced by DiPr-5,6-ADTN at a dose of 40 umol/kg of compound by subcutaneous administration1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
AID176762In vivo DOPA accumulation in non pre-treated rat limbic system following s.c. administration.1987Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
5-hydroxytryptophan
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.. 5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.		1.9610hydroxytryptophanhuman metabolite;
neurotransmitter
dihydroxyphenylalanine
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.. dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.		2.3720hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		human metabolite
8-hydroxy-2-(di-n-propylamino)tetralin
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.. 8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively		2.8840phenols;
tertiary amino compound;
tetralins		serotonergic antagonist
haloperidol
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.		1.9710aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
reserpine
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.		1.9610alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
apomorphine
Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.		2.6630aporphine alkaloidalpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		1.9610butan-4-olidemetabolite;
neurotoxin
n-n-propylnorapomorphine
N-n-propylnorapomorphine: RN given refers to cpd without isomeric designation; structure		1.9610
aj 76
5-methoxy-1-methyl-2-(n-propylamino)tetralin: RN given refers to cis-(+)-isomer; structure given in first source. (1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin : A secondary amino compound that consists of tetralin bearing methyl, propylamino and methoxy groups at positions 1, 2 and 5 respectively. Dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively).		1.9710secondary amino compound;
tetralins		dopaminergic antagonist
5-hydroxy-1-methyl-2--(di-n-propylamino)tetralin methyl ether
UH 232: RN given refers to cis-isomer; RN not in Chemline 9/85; RN and structure given in first source		2.6630
11-hydroxy-n-(n-propyl)noraporphine
11-hydroxy-N-(n-propyl)noraporphine: RN given refers to parent cpd without isomeric designation; (R)-isomer is a dopamine agonist; (S)-isomer is a dopamine antagonist		1.9710
preclamol
preclamol: centrally acting dopamine receptor agonist with selectivity for autoreceptors		2.3720
uh 232
[no description available]		1.9710tetralins
piperidines
Piperidines: A family of hexahydropyridines.		2.3720
ConditionIndicatedRelationship StrengthStudiesTrials