Compounds > 5-deaza-5,6,7,8-tetrahydrofolic acid
Page last updated: 2024-10-15

5-deaza-5,6,7,8-tetrahydrofolic acid

Description

5-deaza-5,6,7,8-tetrahydrofolic acid: RN given refers to (6R)-isomer; RN for cpd without isomeric designation not available 8/89; RN & structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135625342
MeSH IDM0167182

Synonyms (7)

Synonym
l-glutamic acid, n-(4-(((2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)methyl)amino)benzoyl)-, (r)-
115587-73-0
5-deaza-thf
5-deaza-5,6,7,8-tetrahydrofolic acid
(2s)-2-[[4-[[(6r)-2-amino-4-oxo-5,6,7,8-tetrahydro-1h-pyrido[2,3-d]pyrimidin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
DTXSID80151140
(2s)-2-[[4-[[(6r)-2-amino-4-oxo-5,6,7,8-tetrahydro-3h-pyrido[2,3-d]pyrimidin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycineamide ribonucleotide
glycineamide ribonucleotide: structure		210
folic acid
folcysteine: used to promote fertility in chickens. vitamin B9 : Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin.		2.3820folic acids;
N-acyl-amino acid		human metabolite;
mouse metabolite;
nutrient
lometrexol
lometrexol: RN & structure given in first source;		2.6830
s-adenosylmethionine
5-deazafolic acid: structure given in first source		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia, Lymphocytic
[description not available]		01.9810
Leukemia, Lymphoid
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.		01.9810
Breast Cancer
[description not available]		01.9710
Carcinoma, Anaplastic
[description not available]		01.9710
Breast Neoplasms
Tumors or cancer of the human BREAST.		01.9710
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		01.9710
Connective Tissue Diseases
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.		01.9710
Leukemia L 1210
[description not available]		01.9710
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