Compounds > 5-chloro-1,3-dihydroxyacridone
Page last updated: 2024-12-11

5-chloro-1,3-dihydroxyacridone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-chloro-1,3-dihydroxyacridone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5482932
CHEMBL ID252040
SCHEMBL ID16852336
MeSH IDM0366677

Synonyms (8)

Synonym
5-chloro-1,3-dihydroxyacridone
5-chloro-1,3-dihydroxy-10h-acridin-9-one
CHEMBL252040
273943-69-4
DTXSID30420515
SCHEMBL16852336
FNIGHIXUKIHUMN-UHFFFAOYSA-N
5-chloro-1,3-dihydroxyacridin-9(10h)-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID88272Therapeutic index (vero CC50/ED50) against HSV-12003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
Anti-herpes simplex virus activity of substituted 1-hydroxyacridones.
AID88268Inhibitory activity against HSV-1 in vero cells2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
Anti-herpes simplex virus activity of substituted 1-hydroxyacridones.
AID218235In vitro cytotoxic concentration in vero cells.2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
Anti-herpes simplex virus activity of substituted 1-hydroxyacridones.
AID88286Inhibitory activity against HSV-2 in vero cells2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
Anti-herpes simplex virus activity of substituted 1-hydroxyacridones.
AID88292Therapeutic index (vero CC50/ED50) against HSV-2; NA= not active2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
Anti-herpes simplex virus activity of substituted 1-hydroxyacridones.
AID313340Antiviral activity against acyclovir-resistant HSV1 AR29 replication in Vero cells after 72 hrs2008Bioorganic & medicinal chemistry, Jan-01, Volume: 16, Issue:1
SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine series.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.03 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.82 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phosphonoacetic acid
Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.. phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.		2.0110monocarboxylic acid;
phosphonic acids		antiviral agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor
acridines
Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.		2.730acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene		genotoxin
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.43202-aminopurines;
oxopurine		antimetabolite;
antiviral drug
ConditionIndicatedRelationship StrengthStudiesTrials
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		02.0110
Herpes Simplex Virus Infection
[description not available]		02.0110
Herpes Simplex
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)		07.0110