5-carbethoxy-2-thiouracil: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 735952 |
| CHEMBL ID | 3272429 |
| SCHEMBL ID | 1810204 |
| SCHEMBL ID | 18585976 |
| MeSH ID | M000600662 |
| Synonym |
|---|
| EU-0037696 |
| einecs 253-749-2 |
| ai3-22945 |
| ethyl 2-thiouracil-5-carboxylate |
| 5-pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-oxo-2-thioxo-, ethyl ester |
| uracil, 5-carbethoxy-2-thio- |
| nsc 11999 |
| 5-pyrimidinecarboxylic acid, 4-hydroxy-2-mercapto-, ethyl ester |
| 4-hydroxy-2-mercapto-5-pyrimidinecarboxylic acid ethyl ester |
| 2-mercapto-5-carbethoxyuracil |
| 5-pyrimidinecarboxylic acid,2,3,4-tetrahydro-4-oxo-2-thio-, ethyl ester |
| nsc-1584 |
| 5-pyrimidinecarboxylic acid,2,3,4-tetrahydro-4-oxo-2-thioxo-, ethyl ester |
| 38026-46-9 |
| nsc1584 |
| ethyl 4-oxo-2-thioxo-1h-pyrimidine-5-carboxylate |
| 5-carbethoxy-2-thiouracil |
| nsc-11999 |
| nsc11999 |
| IDI1_030947 |
| SR-01000635476-1 |
| 5-pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-oxo-2-thio-, ethyl ester |
| MAYBRIDGE4_000365 |
| NCGC00177658-01 |
| HMS1522A13 |
| AKOS001457140 |
| BRD-K55244769-001-01-2 |
| ethyl 4-hydroxy-2-sulfanylpyrimidine-5-carboxylate |
| STL087653 |
| ethyl 4-oxo-2-sulfanylidene-1h-pyrimidine-5-carboxylate |
| F2145-0075 |
| ethyl 2-mercapto-6-oxo-1,6-dihydropyrimidine-5-carboxylate |
| AKOS001922184 |
| ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
| A18706 |
| CCG-45725 |
| FT-0613453 |
| ethyl 4-hydroxy-2-mercaptopyrimidine-5-carboxylate |
| CHEMBL3272429 |
| CS-B0229 |
| 2-mercapto-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester |
| ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate |
| 5-carboethoxy-2-thiouracil |
| 5-ethoxycarbonyl-2-thiouracil |
| AKOS024015190 |
| SCHEMBL1810204 |
| J-640148 |
| ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate # |
| J-521022 |
| J-800152 |
| F0913-0248 |
| DTXSID30191435 |
| mfcd00006074 |
| ethyl 6-oxo-2-sulfanyl-1,6-dihydro-5-pyrimidinecarboxylate |
| SCHEMBL18585976 |
| 2-mercapto-4-hydroxy-5-ethoxycarbonylpyrimidine |
| ethyl 4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
| AS-71657 |
| ethyl4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
| sr-01000428889 |
| SR-01000428889-1 |
| BCP25539 |
| SB58952 |
| ethyl 6-oxo-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate |
| EN300-238472 |
| Z317042702 |
| SY086800 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1145680 | Antibacterial activity against sensitive Escherichia coli ATCC 10536 assessed as reduction in growth | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1145675 | Antibacterial activity against chlorguanide triazine-resistant Lactobacillus casei ATCC 7469 assessed as reduction in growth | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1145671 | Antibacterial activity against sensitive Streptococcus faecium ATCC 8043 assessed as reduction in growth | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1145677 | Antibacterial activity against sensitive Pediococcus cerevisiae ATCC 808 assessed as reduction | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1145672 | Antibacterial activity against chlorguanide triazine-resistant Streptococcus faecium ATCC 8043 assessed as reduction in growth | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1145689 | Antimalarial activity against Plasmodium berghei infected in sc dosed mouse assessed as dose required to survivors for period of 60 days | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1145683 | Antibacterial activity against sensitive Lactobacillus casei ATCC 7469 assessed as reduction in growth in presence of 0.001 ug/ml folic acid | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1145688 | Antimalarial activity against Plasmodium berghei infected in sc dosed mouse assessed as active dose required to increase of 100% in mean survival time | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1145674 | Antibacterial activity against sensitive Lactobacillus casei ATCC 7469 assessed as reduction | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1145676 | Fold increase in resistance, ratio of IC50 for chlorguanide triazine-resistant Lactobacillus casei ATCC 7469 to IC50 for sensitive Lactobacillus casei ATCC 7469 | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1145678 | Antibacterial activity against chlorguanide triazine-resistant Pediococcus cerevisiae ATCC 808 assessed as reduction in growth | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||