Compounds > 5-amino-2,4-dihydroxy-alpha-methylphenylethylamine
Page last updated: 2024-09-25

5-amino-2,4-dihydroxy-alpha-methylphenylethylamine

Cross-References

ID SourceID
PubMed CID129444
CHEMBL ID132012
MeSH IDM0197067

Synonyms (10)

Synonym
4-amino-6-(2-amino-propyl)-benzene-1,3-diol
bdbm50031348
5-admp
CHEMBL132012 ,
4-amino-6-(2-aminopropyl)benzene-1,3-diol
5-amino-2,4-dihydroxy-alpha-methylphenylethylamine
106868-44-4
1,3-benzenediol, 4-amino-6-(2-aminopropyl)-
1-(5-amino-2,4-dihydroxyphenyl)-2-aminopropane
DTXSID20910157

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)Ki0.11200.00030.37088.1600AID65474
TransporterRattus norvegicus (Norway rat)Ki0.04600.00010.866710.0000AID145874
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (40)

Assay IDTitleYearJournalArticle
AID139835Noradrenergic effect was determined by depletion effect of Nerepinephrine (NE) in mouse brain regions expressed as d501995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID65474Evaluated for the Competitive inhibition of uptake of dopamine transporter1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139661Long term depletion of Dopamine(DA) in Whole mouse Brain region of medulla-pons at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139813Long term depletion of Norepinephrine (NE) in Whole mouse Brain, region of midbrain at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139836Noradrenergic effect was determined by depletion effect of Serotonin(5-HT) in mouse brain regions expressed as d501995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139818Long term depletion of Serotonin(5-HT) in Whole mouse Brain region of cortex at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139839Noradrenergic effect was determined by depletion effect of Serotonin(5-HT) in mouse brain regions expressed as log d501995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID175698Evaluated for the stimulation of synaptosomal release of norepinephrine (release constant)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139837Noradrenergic effect was determined by depletion effect of Dopamine(DA) in mouse brain regions expressed as log d501995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139820Long term depletion of Serotonin(5-HT) in Whole mouse Brain region of hypothalamus at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139668Long term depletion of Norepinephrine (NE) in Whole mouse Brain region of cerebellum at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139819Long term depletion of Serotonin(5-HT) in Whole mouse Brain region of hippocampus at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139838Noradrenergic effect was determined by depletion effect of Nerepinephrine (NE) in mouse brain regions expressed as log d501995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139666Long term depletion of Norepinephrine (NE) in Whole mouse Brain at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139658Long term depletion of Dopamine(DA) in Whole mouse Brain region of hippocampus at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139667Long term depletion of Norepinephrine (NE) in Whole mouse Brain at a low dose (60 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139654Long term depletion of Dopamine(DA) in Whole mouse Brain at a low dose (60 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139823Long term depletion of Serotonin(5-HT) in Whole mouse Brain region of striatum at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139664Long term depletion of Dopamine(DA) in Whole mouse Brain region of thalamus at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139653Long term depletion of Dopamine(DA) in Whole mouse Brain at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139808Long term depletion of Norepinephrine (NE) in Whole mouse Brain region of hypothalamus at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139821Long term depletion of Serotonin(5-HT) in Whole mouse Brain region of medulla-pons at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139816Long term depletion of Serotonin(5-HT) in Whole mouse Brain at a low dose (60 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139834Noradrenergic effect was determined by depletion effect of Dopamine(DA) in mouse brain regions expressed as d501995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID145874Evaluated for the Competitive inhibition of uptake of norepinephrine1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139815Long term depletion of Serotonin(5-HT) in Whole mouse Brain at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID175697Evaluated for the stimulation of synaptosomal release of Dopamine (release constant)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139825Long term depletion of Serotonin(5-HT) in Whole mouse Brain, region of midbrain at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139812Long term depletion of Norepinephrine (NE) in Whole mouse Brain region of thalamus at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139657Long term depletion of Dopamine(DA) in Whole mouse Brain region of cortex at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139809Long term depletion of Norepinephrine (NE) in Whole mouse Brain region of medulla-pons at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139806Long term depletion of Norepinephrine (NE) in Whole mouse Brain region of hippocampus at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139663Long term depletion of Dopamine(DA) in Whole mouse Brain region of striatum at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139811Long term depletion of Norepinephrine (NE) in Whole mouse Brain region of striatum at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139655Long term depletion of Dopamine(DA) in Whole mouse Brain region of cerebellum at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139817Long term depletion of Serotonin(5-HT) in Whole mouse Brain region of cerebellum at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139824Long term depletion of Serotonin(5-HT) in Whole mouse Brain region of thalamus at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139665Long term depletion of Dopamine(DA) in Whole mouse Brain, region of midbrain at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139659Long term depletion of Dopamine(DA) in Whole mouse Brain region of hypothalamus at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
AID139804Long term depletion of Norepinephrine (NE) in Whole mouse Brain region of cortex at a high dose (300 nmol)1995Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (80.00)18.2507
2000's2 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
oxidopamine[no description available]medium10benzenetriol;
catecholamine;
primary amino compound		drug metabolite;
human metabolite;
neurotoxin
2,4,5-trihydroxyamphetamine[no description available]medium10
6-aminodopamine[no description available]medium10
oxytocin[no description available]medium50heterodetic cyclic peptide;
peptide hormone		oxytocic;
vasodilator agent
sincalide[no description available]medium10oligopeptide
pituitrin[no description available]medium30
benoxathian[no description available]medium10
ibutamoren mesylate[no description available]medium10
propranolol[no description available]medium10naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
phenylephrine[no description available]medium10phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
ConditionIndicatedRelationship StrengthStudiesTrials