Compounds > 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one
Page last updated: 2024-11-13
5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one
Description
5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one: a homoisoflavone with antiangiogenesis activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
cremastranone : A homoisoflavonoid that is 2,3-dihydro-4H-chromen-4-onethat is substituted by hydroxy groups at positions 5 and 7, a methoxy group at position 6, and a 3-hydroxy-4-methoxybenzyl group at position 3. It has been isolated from various plants, including the bulb of Cremastra appendiculata. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|
| Cremastra | genus | [no description available] | Orchidaceae | A plant family of the order Asparagales. All members of the orchid family have the same bilaterally symmetrical flower structure, with three sepals, but the flowers vary greatly in color and shape.[MeSH] |
Cross-References
Synonyms (12)
| Synonym |
|---|
| 3-(3-hydroxy-4-methoxybenzyl)-5,7-dihydroxy-6-methoxychroman-4-one |
| 5,7-dihydroxy-6-methoxy-3-(3'-hydroxy-4'-methoxybenzyl)-4-chromanone |
| 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one |
| cremastranone |
| 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxy-2,3-dihydro-4h-chromen-4-one |
| CHEBI:132956 |
| SCHEMBL3355849 |
| CHEMBL3581076 |
| DSTDMPAJBBOFCE-UHFFFAOYSA-N |
| 107585-69-3 (racemic) |
| 5,7-dihydroxy-3-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2,3-dihydrochromen-4-one |
| 107585-69-3 |
Roles (2)
| Role | Description |
|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| angiogenesis modulating agent | An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (3)
| Class | Description |
|---|
| homoisoflavonoid | Any homoflavonoid characterized by addition of an extra carbon atom to the C6-C3-C6 backbone of the isoflavonoid skeleton. |
| aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
| polyphenol | Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (4)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID1229675 | Growth inhibition of human HREC cells assessed as reduction in cell number after 48 hrs by alamarBlue based fluorescence assay | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization. |
| AID1229676 | Growth inhibition of human HUVEC cells assessed as reduction in cell number after 48 hrs by alamarBlue based fluorescence assay | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization. |
| AID1229678 | Growth inhibition of human Y79 cells assessed as reduction in cell number after 48 hrs by alamarBlue based fluorescence assay | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization. |
| AID1229677 | Growth inhibition of human 92-1 cells assessed as reduction in cell number after 48 hrs by alamarBlue based fluorescence assay | 2015 | Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12
| Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.79
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.79 (24.57) | | Research Supply Index | 1.95 (2.92) | | Research Growth Index | 4.73 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |