Compounds > 5,6-dihydroxy-8-aminoquinoline
Page last updated: 2024-10-15

5,6-dihydroxy-8-aminoquinoline

Description

5,6-dihydroxy-8-aminoquinoline: metabolite of primaquine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135502413
CHEMBL ID1213
SCHEMBL ID5640903
MeSH IDM0040995

Synonyms (10)

Synonym
5,6-dihydroxy-8-aminoquinoline
CHEMBL1213
8-amino-6-hydroxy-1h-quinolin-5-one
AKOS006272879
17605-92-4
8-amino-5,6-quinolinediol
8-amino-6-hydroxyquinolin-5(1h)-one
SCHEMBL5640903
8-aminoquinoline-5,6-diol
DTXSID30938746
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID91126In vitro methemoglobin (metHb) forming activity in normal human erythrocytes.1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of certain hydroxy analogues of the antimalarial drug primaquine and their in vitro methemoglobin-producing and glutathione-depleting activity in human erythrocytes.
AID91124In vitro methemoglobin (metHb) forming activity in Glucose-6-phosphate dehydrogenase- (G6PD-) deficient human erythrocytes at 0.05 mM1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of certain hydroxy analogues of the antimalarial drug primaquine and their in vitro methemoglobin-producing and glutathione-depleting activity in human erythrocytes.
AID91118In vitro decreasing the GSH content in normal in human erythrocytes at 0.05 mM1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of certain hydroxy analogues of the antimalarial drug primaquine and their in vitro methemoglobin-producing and glutathione-depleting activity in human erythrocytes.
AID91117In vitro decreasing the GSH content in normal in human erythrocytes at 0.01 mM1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of certain hydroxy analogues of the antimalarial drug primaquine and their in vitro methemoglobin-producing and glutathione-depleting activity in human erythrocytes.
AID91125In vitro methemoglobin (metHb) forming activity in normal human erythrocytes at 0.05 mM1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of certain hydroxy analogues of the antimalarial drug primaquine and their in vitro methemoglobin-producing and glutathione-depleting activity in human erythrocytes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		1.9610monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
primaquine
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404). primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.		2.8840aminoquinoline;
aromatic ether;
N-substituted diamine		antimalarial
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.		1.9710ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
ditiocarb
Ditiocarb: A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.. diethyldithiocarbamic acid : A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.		1.9710dithiocarbamic acidschelator;
copper chelator
thiobarbituric acid
thiobarbituric acid: RN given refers to parent cpd. 2-thiobarbituric acid : A barbiturate, the structure of which is that of barbituric acid in which the oxygen at C-2 is replaced by sulfur.		1.9810barbituratesallergen;
reagent
daphnetin
[no description available]		210hydroxycoumarin
5-hydroxyprimaquine
5-hydroxyprimaquine: structure given in first source; RN given refers to parent cpd		2.3720aminoquinoline
ConditionIndicatedRelationship StrengthStudiesTrials
Extravascular Hemolysis
[description not available]		02.3820
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.3820
Deficiency of Glucose-6-Phosphate Dehydrogenase
[description not available]		02.3720
Glucosephosphate Dehydrogenase Deficiency
A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.		02.3720