Compounds > 5'-o-dimethyltritylthymidine
Page last updated: 2024-12-08

5'-o-dimethyltritylthymidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID162419
CHEMBL ID3143147
SCHEMBL ID1775528
MeSH IDM0091171

Synonyms (40)

Synonym
c31h32n2o7
dmtr-t
1-[(2r,4s,5r)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
dimethoxytrityl-t
5'-o-(4,4'-dimethoxytrityl)thymidine, 98%
dmt-t
D3566
5'-o-(4,4'-dimethoxytrityl)thymidine
40615-39-2
1-[(2r,4s,5r)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
thymidine, 5'-o-(bis(4-methoxyphenyl)phenylmethyl)-
5'-o-(p,p'-dimethoxytrityl)thymidine
einecs 255-003-1
5'-o-dimethyltritylthymidine
AKOS015924177
thymidine, 5'-o-[bis(4-methoxyphenyl)phenylmethyl]-
AKOS015895545
J-700115
UBTJZUKVKGZHAD-UPRLRBBYSA-N
1-[(2r,4s,5r)-5-[[bis (4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
5'--o--(4,4'-dimethoxytrityl)thymidine
5'-o-(4,4'-dimethoxytrityl)-thymidine
5'--o--(4,4'-dimethyoxytrityl) thymidine
5'-o-(4,4'-dimethoxytrityl) thymidine
SCHEMBL1775528
W-200841
1-(2'deoxy-5'-o-[bis(4-methoxyphenyl)phenylmethyl]-b-d-lyxofuranosyl)thymine
CHEMBL3143147
DTXSID1074961
F21487
DS-14583
1-((2r,4s,5r)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1h,3h)-dione ,
EN300-1718972
1-[(2r,4s,5r)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxyoxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CS-0003908
HY-20140
5'-o-dmt-dt
PD151333
BP-58862
5'-o-dmt-thymidine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thymidine kinase, cytosolicHomo sapiens (human)IC50 (µMol)14.00000.01601.21053.0000AID210699
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (6)

Processvia Protein(s)Taxonomy
nucleobase-containing compound metabolic processThymidine kinase, cytosolicHomo sapiens (human)
deoxyribonucleoside monophosphate biosynthetic processThymidine kinase, cytosolicHomo sapiens (human)
thymidine metabolic processThymidine kinase, cytosolicHomo sapiens (human)
thymidine biosynthetic processThymidine kinase, cytosolicHomo sapiens (human)
protein homotetramerizationThymidine kinase, cytosolicHomo sapiens (human)
DNA synthesis involved in mitotic DNA replicationThymidine kinase, cytosolicHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
thymidine kinase activityThymidine kinase, cytosolicHomo sapiens (human)
protein bindingThymidine kinase, cytosolicHomo sapiens (human)
ATP bindingThymidine kinase, cytosolicHomo sapiens (human)
zinc ion bindingThymidine kinase, cytosolicHomo sapiens (human)
identical protein bindingThymidine kinase, cytosolicHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
nucleusThymidine kinase, cytosolicHomo sapiens (human)
cytosolThymidine kinase, cytosolicHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID213300Compound was evaluated for inhibitory effect against phosphorylation of [methyl-3H]dThd byThymidine Kinase 2 (TK-2);NEA = Not estimated accurately2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.
AID210699Compound was evaluated for inhibitory effect against phosphorylation of [methyl-3H]dThd by HSV-1 Thymidine kinase2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (50.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.46 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.46)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thymidine
[no description available]		2.8940pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
oligonucleotides
[no description available]		2.6630
deoxyguanosine
[no description available]		2.0110purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials