Page last updated: 2024-12-08

5'-methylthiotubercidin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID188350
CHEMBL ID551561
MeSH IDM0076974

Synonyms (17)

Synonym
61893-98-9
2-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methylsulfanylmethyl-tetrahydro-furan-3,4-diol
MTH ,
7-(5-s-methyl-5-thio-beta-d-ribofuranosyl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine
5'-(methylsulfanyl)tubercidin
5'-methylthiotubercidin
5'-deoxy-5'-(methylthio)-tubercidin
DB02933
1NC1
2QTG
CHEMBL551561
(2r,3r,4s,5s)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol
7h-pyrrolo(2,3-d)pyrimidin-4-amine, 7-(5-s-methyl-5-thio-beta-d-ribofuranosyl)-
nsc 373405
7-(5-s-methyl-5-thio-beta-d-ribofuranosyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine
Q27093915
PD007945
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (5)

PathwayProteinsCompounds
methionine salvage cycle III1028
S-methyl-5'-thioadenosine degradation16
autoinducer AI-2 biosynthesis I319
S-methyl-5'-thioadenosine degradation II26
L-methionine salvage cycle III1029

Protein Targets (8)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MTA/SAH nucleosidaseEscherichia coliKi0.75000.75005.375010.0000AID977610
Chain B, MTA/SAH nucleosidaseEscherichia coliKi0.75000.75005.375010.0000AID977610
Chain A, MTA/SAH nucleosidaseEscherichia coliKi0.75000.75005.375010.0000AID977610
Chain B, MTA/SAH nucleosidaseEscherichia coliKi0.75000.75005.375010.0000AID977610
Chain A, 5'-methylthioadenosine nucleosidaseArabidopsis thaliana (thale cress)Ki8.30008.300028.150048.0000AID977610
Chain B, 5'-methylthioadenosine nucleosidaseArabidopsis thaliana (thale cress)Ki8.30008.300028.150048.0000AID977610
Chain A, 5'-methylthioadenosine nucleosidaseArabidopsis thaliana (thale cress)Ki8.30008.300028.150048.0000AID977610
Chain B, 5'-methylthioadenosine nucleosidaseArabidopsis thaliana (thale cress)Ki8.30008.300028.150048.0000AID977610
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID425817Activity at bloodstream Trypanosoma brucei brucei 5'-deoxy-5'-(methylthio)-adenosine phosphorylase by spectrophotometry relative to control2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID422446Antitrypanosomal activity against pentamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243 after 48 hrs by Z1 zoulter counter2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID422448Antitrypanosomal activity against diamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243-As10-3 after 48 hrs by Z1 zoulter counter2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID425815Activity at bloodstream Trypanosoma brucei brucei 5'-deoxy-5'-(methylthio)-adenosine phosphorylase by spectrophotometry in presence of 50 mM PO4- relative to control2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID422447Antitrypanosomal activity against pentamidine-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 269 after 48 hrs by Z1 zoulter counter2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID425816Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei LAB 110 EATRO after 48 hrs by Z1 zoulter counter2008Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID1811Experimentally measured binding affinity data derived from PDB2003The Journal of biological chemistry, Mar-07, Volume: 278, Issue:10
Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2003The Journal of biological chemistry, Mar-07, Volume: 278, Issue:10
Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2008Journal of molecular biology, Apr-18, Volume: 378, Issue:1
Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (50.00)18.7374
1990's0 (0.00)18.2507
2000's5 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.74 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]