Compounds > 5'-methylthiotubercidin

Page last updated: 2024-12-08

5'-methylthiotubercidin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	188350
CHEMBL ID	551561
MeSH ID	M0076974

Synonyms (17)

Synonym
61893-98-9
2-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methylsulfanylmethyl-tetrahydro-furan-3,4-diol
MTH ,
7-(5-s-methyl-5-thio-beta-d-ribofuranosyl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine
5'-(methylsulfanyl)tubercidin
5'-methylthiotubercidin
5'-deoxy-5'-(methylthio)-tubercidin
DB02933
1NC1
2QTG
CHEMBL551561
(2r,3r,4s,5s)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol
7h-pyrrolo(2,3-d)pyrimidin-4-amine, 7-(5-s-methyl-5-thio-beta-d-ribofuranosyl)-
nsc 373405
7-(5-s-methyl-5-thio-beta-d-ribofuranosyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine
Q27093915
PD007945

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (5)

Pathway	Proteins	Compounds
methionine salvage cycle III	10	28
S-methyl-5'-thioadenosine degradation	1	6
autoinducer AI-2 biosynthesis I	3	19
S-methyl-5'-thioadenosine degradation II	2	6
L-methionine salvage cycle III	10	29

Protein Targets (8)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, MTA/SAH nucleosidase	Escherichia coli	Ki	0.7500	0.7500	5.3750	10.0000	AID977610
Chain B, MTA/SAH nucleosidase	Escherichia coli	Ki	0.7500	0.7500	5.3750	10.0000	AID977610
Chain A, MTA/SAH nucleosidase	Escherichia coli	Ki	0.7500	0.7500	5.3750	10.0000	AID977610
Chain B, MTA/SAH nucleosidase	Escherichia coli	Ki	0.7500	0.7500	5.3750	10.0000	AID977610
Chain A, 5'-methylthioadenosine nucleosidase	Arabidopsis thaliana (thale cress)	Ki	8.3000	8.3000	28.1500	48.0000	AID977610
Chain B, 5'-methylthioadenosine nucleosidase	Arabidopsis thaliana (thale cress)	Ki	8.3000	8.3000	28.1500	48.0000	AID977610
Chain A, 5'-methylthioadenosine nucleosidase	Arabidopsis thaliana (thale cress)	Ki	8.3000	8.3000	28.1500	48.0000	AID977610
Chain B, 5'-methylthioadenosine nucleosidase	Arabidopsis thaliana (thale cress)	Ki	8.3000	8.3000	28.1500	48.0000	AID977610
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay ID	Title	Year	Journal	Article
AID425817	Activity at bloodstream Trypanosoma brucei brucei 5'-deoxy-5'-(methylthio)-adenosine phosphorylase by spectrophotometry relative to control	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID422446	Antitrypanosomal activity against pentamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243 after 48 hrs by Z1 zoulter counter	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID422448	Antitrypanosomal activity against diamidine and melarsoprol-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 243-As10-3 after 48 hrs by Z1 zoulter counter	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID425815	Activity at bloodstream Trypanosoma brucei brucei 5'-deoxy-5'-(methylthio)-adenosine phosphorylase by spectrophotometry in presence of 50 mM PO4- relative to control	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID422447	Antitrypanosomal activity against pentamidine-resistant bloodstream form of Trypanosoma brucei brucei isolate KETRI 269 after 48 hrs by Z1 zoulter counter	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID425816	Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei LAB 110 EATRO after 48 hrs by Z1 zoulter counter	2008	Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1	Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
AID1811	Experimentally measured binding affinity data derived from PDB	2003	The Journal of biological chemistry, Mar-07, Volume: 278, Issue:10	Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis.
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2003	The Journal of biological chemistry, Mar-07, Volume: 278, Issue:10	Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis.
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2008	Journal of molecular biology, Apr-18, Volume: 378, Issue:1	Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (50.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.74 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.14 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.74)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
adenine [no description available]	1.96	1	0	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
9-(2-hydroxy-3-nonyl)adenine 9-(2-hydroxy-3-nonyl)adenine: specific inhibitor of adenosine deaminase	1.96	1	0
thymidine [no description available]	1.95	1	0	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	2.02	1	0	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
tubercidin Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.	3.35	7	0	antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; ribonucleoside	antimetabolite; antineoplastic agent; bacterial metabolite
homoserine homoserine : An alpha-amino acid that is glycine substituted at the alpha-position by a 2-hydroxyethyl group.. L-homoserine : The L-enantiomer of homoserine.	2.02	1	0	amino acid zwitterion; homoserine	algal metabolite; Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	3.05	5	0	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
s-adenosyl-3-thiopropylamine S-adenosyl-3-thiopropylamine: decarboxylated S-adenosylhomocysteine; RN given refers to parent cpd. S-adenosyl-3-thiopropylamine : A thioadenosine that is adenosine in which the hydroxy group at C-5' is replaced by a 3-aminopropyl group.	2.04	1	0	organic sulfide; primary amino compound; thioadenosine
5'-methylthioadenosine 5'-methylthioadenosine: structure. 5'-S-methyl-5'-thioadenosine : Adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group.	3.06	5	0	thioadenosine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
formycin [no description available]	2.71	3	0	formycin	antineoplastic agent
ribose ribopyranose : The pyranose form of ribose.	2.02	1	0	D-ribose; ribopyranose
s-adenosylmethionine (R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.	1.95	1	0	organic cation; sulfonium compound	coenzyme; cofactor; human metabolite; micronutrient; Mycoplasma genitalium metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
formycins Formycins: Pyrazolopyrimidine ribonucleosides isolated from Nocardia interforma. They are antineoplastic antibiotics with cytostatic properties.	2.02	1	0