Compounds > 5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine
Page last updated: 2024-09-23

5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine

Description

5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID359063
MeSH IDM0158555

Synonyms (4)

Synonym
nsc619504
thymidine, 5'-(1-methyl-3- pyridinecarboxylate)
nsc-619504
5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's6 (75.00)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
zidovudine[no description available]medium80azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
dihydropyridines[no description available]medium80
3'-azido-3'-deoxythymidine 5'phosphate[no description available]medium10
3'-azido-2',3'-dideoxyuridine[no description available]medium10
thymidine[no description available]medium10pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Acquired Immune Deficiency Syndrome0low20
Acquired Immuno-Deficiency Syndrome0low20
Acquired Immunodeficiency Syndrome0low20
Acquired-Immune Deficiency Syndrome Dementia Complex0low10
AIDS0low20
AIDS Dementia Complex0low10
AIDS Encephalopathy0low10
AIDS-Related Dementia Complex0low10
Amentia0low10
Dementia0low10
Dementia Complex, Acquired Immune Deficiency Syndrome0low10
Dementia Complex, AIDS-Related0low10
Encephalopathy, AIDS0low10
Encephalopathy, HIV0low10
Familial Dementia0low10
HIV0low20
HIV Dementia0low10
HIV Encephalopathy0low10
HIV-1 Cognitive and Motor Complex0low10
HIV-1-Associated Cognitive Motor Complex0low10
HIV-Associated Cognitive Motor Complex0low10
Immunodeficiency Syndrome, Acquired0low20
Immunologic Deficiency Syndrome, Acquired0low20
Senile Paranoid Dementia0low10

Research Highlights

Pharmacokinetics (2)

ArticleYear
Intracellular metabolism and pharmacokinetics of 5'-hydrogenphosphonate of 3'-azido-2',3'-dideoxythymidine, a prodrug of 3'-azido-2',3'-dideoxythymidine.
Antiviral research, Volume: 63, Issue: 2		2004
Comparative pharmacokinetics of two prodrugs of zidovudine in rabbits: enhanced levels of zidovudine in brain tissue.
Antimicrobial agents and chemotherapy, Volume: 37, Issue: 4		1993
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
Brain, blood, and cerebrospinal fluid distribution of a zidovudine chemical delivery system in rabbits.
Journal of pharmaceutical sciences, Volume: 80, Issue: 9		1991
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]