Compounds > 5-(4-(dimethylamino)benzylidene)rhodanine
Page last updated: 2024-12-09

5-(4-(dimethylamino)benzylidene)rhodanine

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Description

5-(4-(dimethylamino)benzylidene)rhodanine: silver-specific dye [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID2723826
CHEMBL ID1736327
MeSH IDM0140183

Synonyms (39)

Synonym
4-thiazolidinone, 5-((4-(dimethylamino)phenyl)methylene)-2-thioxo-
brn 0189065
nsc 5042
5-(p-dimethylaminobenzoylidene)rhodanine
4-dimethylaminobenzylidenerhodanine
5-(4-(dimethylamino)benzylidene)rhodanine
5-(p-(dimethylamino)benzylidene)rhodanine
5-(p-dimethylaminobenzal)rhodanine
einecs 208-625-2
UPCMLD0ENAT0508-8324:001
rhodanine, 5-(p-(dimethylamino)benzylidene)-
usaf pd-20
nsc-5042
5-(4-dimethylaminobenzylidene)rhodanine
p-(dimethylamino)benzal-5-rhodanine
mls002637787 ,
536-17-4
p-dimethylaminobenzalrhodanine
p-(dimethylamino)benzylidenerhodanine
4-thiazolidinone, 5-[[4-(dimethylamino)phenyl]methylene]-2-thioxo-
p-dimethylaminobenzylidene rhodamine
ENAMINE_003130
NCI60_004214
smr001547304
HMS3078M09
4-27-00-05697 (beilstein handbook reference)
unii-0ser53q7rt
0ser53q7rt ,
p-dimethylaminobenzalrhodanine [mi]
5-((4-(dimethylamino)phenyl)methylene)-2-thioxo-4-thiazolidinone
AKOS023093327
DTXSID7060207
p-dimethylaminobenzalrhodanin
4'-(dimethylamino)benzalrhodanine
CHEMBL1736327
mfcd00064857
Q3599219
5-[4-(dimethylamino)benzylidene]-2-thioxo-4-thiazolidinone
SY010162
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (23)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency31.62280.631035.7641100.0000AID504339
glp-1 receptor, partialHomo sapiens (human)Potency2.51190.01846.806014.1254AID624417
BRCA1Homo sapiens (human)Potency2.23870.89137.722525.1189AID624202
WRNHomo sapiens (human)Potency79.43280.168331.2583100.0000AID651768
USP1 protein, partialHomo sapiens (human)Potency39.81070.031637.5844354.8130AID743255
TDP1 proteinHomo sapiens (human)Potency14.58100.000811.382244.6684AID686978
Smad3Homo sapiens (human)Potency12.58930.00527.809829.0929AID588855
67.9K proteinVaccinia virusPotency6.30960.00018.4406100.0000AID720580
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency16.36010.00419.984825.9290AID504444
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency6.30960.794321.275750.1187AID624246
importin subunit beta-1 isoform 1Homo sapiens (human)Potency13.34775.804836.130665.1308AID540253; AID540263
flap endonuclease 1Homo sapiens (human)Potency84.92140.133725.412989.1251AID720498
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency5.32330.168316.404067.0158AID720504
snurportin-1Homo sapiens (human)Potency13.34775.804836.130665.1308AID540253; AID540263
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency1.19950.425612.059128.1838AID504891
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency17.78285.804816.996225.9290AID540253
DNA polymerase eta isoform 1Homo sapiens (human)Potency25.11890.100028.9256213.3130AID588591
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency14.12540.050127.073689.1251AID588590
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency10.36600.058010.694926.6086AID602310; AID651812; AID651813
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency11.57310.025911.239831.6228AID602313; AID651814; AID651815
Guanine nucleotide-binding protein GHomo sapiens (human)Potency19.95261.995325.532750.1187AID624288
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
corticotropin-releasing hormone receptor 2Homo sapiens (human)EC50 (µMol)4.78001.120011.561736.8000AID602473
corticotropin releasing factor-binding proteinHomo sapiens (human)EC50 (µMol)4.78001.120011.561736.8000AID602473
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's1 (14.29)18.2507
2000's1 (14.29)29.6817
2010's2 (28.57)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.56 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thiazoles
[no description available]		1.96101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
hematoxylin
Hematoxylin: A dye obtained from the heartwood of logwood (Haematoxylon campechianum Linn., Leguminosae) used as a stain in microscopy and in the manufacture of ink.		1.9910organic heterotetracyclic compound;
oxacycle;
polyphenol;
tertiary alcohol		histological dye;
plant metabolite
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		1.9610copper group element atom;
elemental silver		Escherichia coli metabolite
rhodanine
2-mercaptothiazolinone: metabolite in urine from persons exposed to CS2; structure		2.6730thiazolidinone
rubeanic acid
rubeanic acid: indicator for copper, cobalt, & nickel; structure		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510