Compounds > 4-toluoyl chloride phenylhydrazone
Page last updated: 2024-12-11

4-toluoyl chloride phenylhydrazone

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Description

4-toluoyl chloride phenylhydrazone: RN given refers to parent [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID7280190
CHEMBL ID146851
MeSH IDM0059703

Synonyms (8)

Synonym
p-toluoyl chloride phenylhydrazone
4-methyl-n-phenylbenzenecarbohydrazonoyl chloride
CHEMBL146851
(1z)-4-methyl-n-phenylbenzenecarbohydrazonoyl chloride
25939-01-9
4-toluoyl chloride phenylhydrazone
benzenecarbohydrazonoyl chloride, 4-methyl-n-phenyl-
ai3-29019
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (46)

Assay IDTitleYearJournalArticle
AID205098Percent reduction in Oesophagostomum eggs per gram, after treatment with 100 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205252Percent reduction in Strongyloides eggs per gram, after treatment with 200 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID58733Percent reduction in Uncinaria eggs per gram, after treatment with 275 mg/dog dose of compound in a single treatment1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID58720Percent reduction in Toxascaris eggs per gram, after treatment with 200 mg/dog dose of compound in a single treatment1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205404Percent reduction in Trichostrongylus eggs per gram, after treatment with 300 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID204931Percent reduction in Cooperia eggs per gram, after treatment with 100 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205401Percent reduction in Trichostrongylus eggs per gram, after treatment with 200 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205083Percent reduction in Nematodirus eggs per gram, after treatment with 100 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205235Percent reduction in Ostertagia eggs per gram, after treatment with 200 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID58584Percent reduction in Ancylostoma eggs per gram, after treatment with 200 mg/dog dose of compound in a single treatment1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205242Percent reduction in Ostertagia eggs per gram, after treatment with 400 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID58586Percent reduction in Ancylostoma eggs per gram, after treatment with 275 mg/dog dose of compound in a single treatment1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205233Percent reduction in Ostertagia eggs per gram, after treatment with 150 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID127768Percent clearance of Nematospiroides dubius from mouse oral treatment of 0.25 mg/mouse/day of compound1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205077Percent reduction in Moniezia eggs per gram, after treatment with 150 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID127769Percent clearance of Syphacaia obvelata from mouse after oral treatment of 0.25 mg/mouse/day of compound1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205249Percent reduction in Strongyloides eggs per gram, after treatment with 150 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205247Percent reduction in Strongyloides eggs per gram, after treatment with 100 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205084Percent reduction in Nematodirus eggs per gram, after treatment with 150 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID58721Percent reduction in Trichuris eggs per gram, after treatment with 200 mg/dog dose of compound in a single treatment1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205399Percent reduction in Trichostrongylus eggs per gram, after treatment with 150 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205067Percent reduction in Haemonchus eggs per gram, after treatment with 200 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205408Percent reduction in Trichostrongylus eggs per gram, after treatment with 400 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205421Percent reduction in Trichuris eggs per gram, after treatment with 300 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205100Percent reduction in Oesophagostomum eggs per gram, after treatment with 150 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID58732Percent reduction in Uncinaria eggs per gram, after treatment with 250 mg/dog dose of compound in a single treatment1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID58731Percent reduction in Uncinaria eggs per gram, after treatment with 200 mg/dog dose of compound in a single treatment1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205259Percent reduction in Strongyloides eggs per gram, after treatment with 400 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205102Percent reduction in Oesophagostomum eggs per gram, after treatment with 200 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205232Percent reduction in Ostertagia eggs per gram, after treatment with 100 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205063Percent reduction in Haemonchus eggs per gram, after treatment with 100 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205415Percent reduction in Trichuris eggs per gram, after treatment with 100 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205266Percent reduction in Trichostrongylus eggs per gram, after treatment with 100 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205223Percent reduction in Oesophagostomum eggs per gram, after treatment with 300 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205238Percent reduction in Ostertagia eggs per gram, after treatment with 300 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205418Percent reduction in Trichuris eggs per gram, after treatment with 200 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205425Percent reduction in Trichuris eggs per gram, after treatment with 400 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205065Percent reduction in Haemonchus eggs per gram, after treatment with 150 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205255Percent reduction in Strongyloides eggs per gram, after treatment with 300 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205089Percent reduction in Nematodirus eggs per gram, after treatment with 300 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID58585Percent reduction in Ancylostoma eggs per gram, after treatment with 250 mg/dog dose of compound in a single treatment1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205092Percent reduction in Nematodirus eggs per gram, after treatment with 400 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205070Percent reduction in Haemonchus eggs per gram, after treatment with 300 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205416Percent reduction in Trichuris eggs per gram, after treatment with 150 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205086Percent reduction in Nematodirus eggs per gram, after treatment with 200 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
AID205073Percent reduction in Haemonchus eggs per gram, after treatment with 400 mg/kg dose of compound in sheep perorally1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Structure--activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. 1. Aryl substitutions and chloride variations.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
albendazole
[no description available]		1.9710aryl sulfide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		anthelminthic drug;
microtubule-destabilising agent;
tubulin modulator
dichlorvos
Dichlorvos: An organophosphorus insecticide that inhibits ACETYLCHOLINESTERASE.. dichlorvos : An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.		1.9710alkenyl phosphate;
dialkyl phosphate;
organochlorine acaricide;
organophosphate insecticide		anthelminthic drug;
antibacterial agent;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
levamisole
Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6). levamisole : A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.		1.97106-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazoleantinematodal drug;
antirheumatic drug;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
immunological adjuvant;
immunomodulator
pyrantel pamoate
Pyrantel Pamoate: Broad spectrum antinematodal anthelmintic used also in veterinary medicine.		1.9710organic molecular entity
dextrothyroxine
[no description available]		2.3720
ConditionIndicatedRelationship StrengthStudiesTrials
Canine Diseases
[description not available]		01.9610
Infections, Nematomorpha
[description not available]		01.9610
Infections, Nematode
[description not available]		01.9610
Ovine Diseases
[description not available]		02.3620
Aspiculariasis
[description not available]		01.9610
Hymenolepiasis
Infection with tapeworms of the genus Hymenolepis.		01.9610
Helminthiasis, Animal
Infestation of animals with parasitic worms of the helminth class. The infestation may be experimental or veterinary.		02.3620
Helminthiasis
Infestation with parasitic worms of the helminth class.		01.9610
Gastric Diseases
[description not available]		01.9510
Intestinal Diseases, Parasitic
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.		01.9510
Ostertagiasis
A disease of herbivorous mammals, particularly cattle and sheep, caused by stomach worms of the genus OSTERTAGIA.		01.9510
Haemonchiasis
Infection with nematodes of the genus HAEMONCHUS, characterized by digestive abnormalities and anemia similar to that from hookworm infestation.		01.9510
Monieziasis
Infection of ruminants with tapeworms of the genus Moniezia.		01.9510
Oesophagostomiasis
Infection of the intestinal tract with worms of the genus OESOPHAGOSTOMUM. This condition occurs mainly in animals other than man.		01.9510
Trichostrongyloidiasis
Infection by roundworms of the superfamily TRICHOSTRONGYLOIDEA, including the genera TRICHOSTRONGYLUS; OSTERTAGIA; Cooperia, HAEMONCHUS; Nematodirus, Hyostrongylus, and DICTYOCAULUS.		01.9510
Equine Strongyle Infections
[description not available]		01.9710