Compounds > 4-pyridylmethylamine
Page last updated: 2024-12-07

4-pyridylmethylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-Pyridylmethylamine, also known as 4-aminomethylpyridine, is an organic compound with the formula C6H7N2. It is a colorless liquid that is soluble in water and organic solvents. 4-Pyridylmethylamine is a versatile building block in organic synthesis and is used in the preparation of various pharmaceuticals and agrochemicals. It is also known to exhibit biological activity, such as acting as a serotonin reuptake inhibitor, an enzyme inhibitor, and a potential therapeutic agent for Alzheimer's disease. Further research is ongoing to explore its full potential in various fields, including medicinal chemistry, material science, and agricultural chemistry.'

4-pyridylmethylamine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID77317
CHEMBL ID1188378
SCHEMBL ID41000
MeSH IDM0131856

Synonyms (72)

Synonym
einecs 223-092-6
ai3-52439
(4-pyridylmethyl)amine
nsc 59707
4-picolylamine
4-pyridylmethylamine
pyridine, 4-(aminomethyl)-
4-(aminomethyl)pyridine
4-picolinylamine
nsc59707
4-picolinamine
4-aminomethylpyridine
3731-53-1
nsc-59707
4-pyridinemethylamine
4-pyridinemethanamine
1-pyridin-4-ylmethanamine
inchi=1/c6h8n2/c7-5-6-1-3-8-4-2-6/h1-4h,5,7h
4-(aminomethyl)pyridine, 98%
AKOS000118826
P0779
HMS1733E16
pyridin-4-ylmethanamine
A6389
4-pyridinemethaneamine
c-pyridin-4-yl-methylamine
CHEMBL1188378 ,
pyridin-4-yl-methyl-amine
AM803800
FT-0619419
AB00767
(pyridin-4-yl)methanamine
SCHEMBL41000
J-502089
DTXSID0063153
(pyridin-4-ylmethyl)amine
1-(4-pyridinyl)methylamine
4-pyridylmethyl-amine
4-aminomethyl pyridine
1-(pyridin-4-yl)methanamine
4-aminomethyl-pyridine
4-pyridinylmethanamine
(4-pyridinylmethyl)amine
4-(aminomethyl)-pyridine
pyridin-4-ylmethylamine
4-(aminomethyl) pyridine
(pyridine-4-ylmethyl)amine
4-amino methyl pyridine
4-pyridinylmethylamine
(4-pyridinylmethyl) amine
4-(amino-methyl)pyridine
(4-pyridyl)methanamine
4-(aminomethyl)pyridin
(4-pyridyl)methylamine
c-pyridin-4-ylmethylamine
.gamma.-picolylamine
STR00571
TS-01532
mfcd00006449
J-523660
n-methyl-4-pyrdnamne
CS-W007632
F2190-0500
pyridine-4-methanamine
BCP22963
Q27463887
bdbm50232687
F11237
discontinued see: g419100
EN300-19585
Z104474354
HY-W007632
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Lysyl oxidase homolog 2Homo sapiens (human)IC50 (µMol)1.22000.06600.56494.2600AID1430567
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (15)

Processvia Protein(s)Taxonomy
negative regulation of transcription by RNA polymerase IILysyl oxidase homolog 2Homo sapiens (human)
response to hypoxiaLysyl oxidase homolog 2Homo sapiens (human)
epithelial to mesenchymal transitionLysyl oxidase homolog 2Homo sapiens (human)
endothelial cell proliferationLysyl oxidase homolog 2Homo sapiens (human)
sprouting angiogenesisLysyl oxidase homolog 2Homo sapiens (human)
positive regulation of epithelial to mesenchymal transitionLysyl oxidase homolog 2Homo sapiens (human)
peptidyl-lysine oxidationLysyl oxidase homolog 2Homo sapiens (human)
collagen fibril organizationLysyl oxidase homolog 2Homo sapiens (human)
positive regulation of chondrocyte differentiationLysyl oxidase homolog 2Homo sapiens (human)
protein modification processLysyl oxidase homolog 2Homo sapiens (human)
endothelial cell migrationLysyl oxidase homolog 2Homo sapiens (human)
negative regulation of DNA-templated transcriptionLysyl oxidase homolog 2Homo sapiens (human)
response to copper ionLysyl oxidase homolog 2Homo sapiens (human)
heterochromatin organizationLysyl oxidase homolog 2Homo sapiens (human)
negative regulation of stem cell population maintenanceLysyl oxidase homolog 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
protein-lysine 6-oxidase activityLysyl oxidase homolog 2Homo sapiens (human)
copper ion bindingLysyl oxidase homolog 2Homo sapiens (human)
calcium ion bindingLysyl oxidase homolog 2Homo sapiens (human)
protein bindingLysyl oxidase homolog 2Homo sapiens (human)
oligosaccharide bindingLysyl oxidase homolog 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
collagen-containing extracellular matrixLysyl oxidase homolog 2Homo sapiens (human)
basement membraneLysyl oxidase homolog 2Homo sapiens (human)
extracellular spaceLysyl oxidase homolog 2Homo sapiens (human)
nucleusLysyl oxidase homolog 2Homo sapiens (human)
nucleoplasmLysyl oxidase homolog 2Homo sapiens (human)
endoplasmic reticulumLysyl oxidase homolog 2Homo sapiens (human)
membraneLysyl oxidase homolog 2Homo sapiens (human)
collagen-containing extracellular matrixLysyl oxidase homolog 2Homo sapiens (human)
chromatinLysyl oxidase homolog 2Homo sapiens (human)
collagen-containing extracellular matrixLysyl oxidase homolog 2Homo sapiens (human)
extracellular spaceLysyl oxidase homolog 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1430567Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated for 2 hrs followed by substrate addition measured every 2 minutes for 50 minutes by Amplex red dye based 2017ACS medicinal chemistry letters, Apr-13, Volume: 8, Issue:4
Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.51 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methane
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).		2.0310alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
phenethylamine
phenethylamine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7016. 2-phenylethylamine : A phenylethylamine having the phenyl substituent at the 2-position.		2.1510alkaloid;
aralkylamine;
phenylethylamine		Escherichia coli metabolite;
human metabolite;
mouse metabolite
aminopropionitrile
Aminopropionitrile: Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.		2.1510aminopropionitrileantineoplastic agent;
antirheumatic drug;
collagen cross-linking inhibitor;
plant metabolite
benzylamine
aminotoluene : Any member of the class of toluenes carrying one or more amino groups.		2.1510aralkylamine;
primary amine		allergen;
EC 3.5.5.1 (nitrilase) inhibitor;
plant metabolite
1-octene
1-octene: RN given refers to parent cpd. 1-octene : An octene with an unsaturation C-1.		2.0810octene
nitrosoguanidines
Nitrosoguanidines: Nitrosylated derivatives of guanidine. They are used as MUTAGENS in MOLECULAR BIOLOGY research.		1.9610
4-nitrobenzylamine
4-nitrobenzylamine: RN given refers to parent cpd		2.1510
alkenes
[no description available]		2.0810
glutathione disulfide
Glutathione Disulfide: A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.		2.0810glutathione derivative;
organic disulfide		Escherichia coli metabolite;
mouse metabolite
naphthalimides
Naphthalimides: Compounds with three fused rings that appear like a naphthalene fused to piperidone or like a benz(de)isoquinoline-1,3-dione (not to be confused with BENZYLISOQUINOLINES which have a methyl separating the naphthyl from the benzyl rings). Members are CYTOTOXINS.		2.0810
4-fluorobenzylamine
[no description available]		2.1510
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0810