Page last updated: 2024-12-04

4-oxatetradecanoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-oxatetradecanoic acid: fungicidal for Cryptococcus neoformans & inhibits replication of HIV I; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1754
CHEMBL ID1871969
SCHEMBL ID6580843
MeSH IDM0205239

Synonyms (41)

Synonym
CBIOL_002024
nsc-666072
BIO2_000641
BIO1_000799
BIO1_000310
BIO1_001288
BIO2_000161
nsc666072
3-decanoxypropanoic acid
3-decoxypropanoic acid
4-om
4-oxymyristic acid
4-oxatetradecanoic acid
BCBCMAP01_000153
IDI1_033911
NCGC00161356-02
NCGC00161356-01
KBIO2_002729
KBIOGR_000161
KBIO3_000322
KBIOSS_000161
KBIO3_000321
KBIO2_000161
KBIO2_005297
BSPBIO_001441
NCGC00161356-03
HMS1989I03
BML3-C07
HMS1361I03
HMS1791I03
7420-16-8
3-(decyloxy)propanoic acid
AKOS003238602
propanoic acid, 3-(decyloxy)-
2-methoxy-4-oxatetradecanoic
propanoic acid,3-(decyloxy)-
DTXSID00225195
SCHEMBL6580843
CHEMBL1871969
4-oxatetradecanoicacid
HMS3402I03
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
regulator of G-protein signaling 4Homo sapiens (human)Potency33.58750.531815.435837.6858AID504845
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1811314Selectivity index, ratio of CC50 for human Huh-7 cells to IC50 for Antiviral activity against Ebola virus trVLP infected in human Huh-7 cells2021European journal of medicinal chemistry, Dec-15, Volume: 226Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus.
AID1811322Antiviral activity against Ebola virus constitutively expressed firefly infected in human Huh-7 cells expressing pretreated for 1 hrs followed by viral infection and measured after 24 hrs by dual luciferase reporter assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus.
AID1811321Antiviral activity against Ebola virus trVLP infected in human Huh-7 cells pretreated for 1 hrs followed by viral infection and measured after 24 hrs by dual luciferase reporter assay2021European journal of medicinal chemistry, Dec-15, Volume: 226Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus.
AID1811315Antiviral activity against SARS Cov-2 USA/WA1/2020 infected in Vero E6 cells assessed as reduction in virus-induced cytopathic effect preincubated for 1 hr followed by viral infection and measured after 48 hrs post infection2021European journal of medicinal chemistry, Dec-15, Volume: 226Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus.
AID1811320Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo analysis2021European journal of medicinal chemistry, Dec-15, Volume: 226Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's1 (11.11)29.6817
2010's4 (44.44)24.3611
2020's3 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.67 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]