Compounds > 4-nitrophenylglycerol
Page last updated: 2024-11-07

4-nitrophenylglycerol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-Nitrophenylglycerol (4-NPG) is a synthetic compound that exhibits various pharmacological effects, including anti-inflammatory, analgesic, and anti-cancer activities. Its synthesis involves the reaction of glycerol with 4-nitrophenol under specific conditions. The compound has been investigated for its potential therapeutic applications in various diseases, including rheumatoid arthritis and cancer. 4-NPG has been shown to inhibit the production of pro-inflammatory cytokines and chemokines, thus reducing inflammation. Moreover, its analgesic effects are attributed to its ability to block pain signals in the central nervous system. The anti-cancer properties of 4-NPG are related to its ability to induce apoptosis in cancer cells. Research on 4-NPG focuses on understanding its mechanisms of action, optimizing its synthesis and formulation, and exploring its potential as a drug candidate for various diseases.'

4-nitrophenylglycerol: antiswarming agent for bacterial cultures [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID102764
CHEMBL ID1836141
SCHEMBL ID2374452
MeSH IDM0065734

Synonyms (27)

Synonym
OPREA1_308530
1-(4-nitrophenyl)glycerol, crystalline
p-nitrophenylglycerol
1-(4-nitrophenyl)glycerol, 99%
MAYBRIDGE1_002064
1-(4-nitrophenyl)glycerol
N-2750
4-nitrophenylglycerol
HMS547F18
1-(4-nitrophenyl)-1,2,3-propanetriol
1-(4-nitrophenyl)propane-1,2,3-triol
CHEMBL1836141
2207-68-3
einecs 218-624-9
para-nitrophenylglycerol
1,2,3-propanetriol, (4-nitrophenyl)-
FT-0605767
AKOS015913436
methyl17-methyloctadecanoate
SCHEMBL2374452
BTB 12954
1,2,3-propanetriol, 1-(4-nitrophenyl)-
mfcd00017037
AS-62950
DTXSID60944693
D87898
CS-0312875
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID620929Antibacterial activity against erythromycin-lincomycin resistant Bacillus subtilis NCIB 3610 DS64 harboring hag deletion mutant assessed as inhibition of surface colony-spreading at 75 ug/ml after 24 hrs relative to control2011Bioorganic & medicinal chemistry letters, Sep-15, Volume: 21, Issue:18
New inhibitors of colony spreading in Bacillus subtilis and Bacillus anthracis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (23.08)18.7374
1990's4 (30.77)18.2507
2000's5 (38.46)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.75 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		2.3920alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		2.0410mitomycinalkylating agent;
antineoplastic agent
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		2.0310erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		2.0210butan-4-olidemetabolite;
neurotoxin
congo red
Congo Red: An acid dye used in testing for hydrochloric acid in gastric contents. It is also used histologically to test for AMYLOIDOSIS.. Congo Red : An indicator dye that is blue-violet at pH 3.0 and red at pH 5.0.		2.0410bis(azo) compound
win 18446
WIN 18446 : A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis. It down-regulates sex related genes in zebrafish.		1.9610organochlorine compound;
secondary carboxamide		EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
ticarcillin
Ticarcillin: An antibiotic derived from penicillin similar to CARBENICILLIN in action.. ticarcillin : A penicillin compound having a 6beta-[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino side-group.		1.9810penicillin allergen;
penicillin		antibacterial drug
homoserine lactone
homoserine lactone: a putative signal for starvation in E. coli; structure in first source. homoserinium lactone : The conjugate acid of homoserine lactone; major species at pH 7.3.. homoserine lactone : A butan-4-olide having an amino substituent at the 2-position.		2.0210ammonium ion derivative;
organic cation
2-(4'-maleimidylanilino)naphthalene-6-sulfonic acid
2-(4'-maleimidylanilino)naphthalene-6-sulfonic acid: RN given refers to mono-Na salt; structure		2.0310
agar
Agar: A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.. agar : A complex mixture of polysaccharides extracted from species of red algae. Its two main components are agarose and agaropectin. Agarose is the component responsible for the high-strength gelling properties of agar, while agaropectin provides the viscous properties.		2.0410
nitrophenols
Nitrophenols: PHENOLS carrying nitro group substituents.		1.9510
ConditionIndicatedRelationship StrengthStudiesTrials