Page last updated: 2024-12-06

4-nitrobenzylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-Nitrobenzylamine is a synthetic compound that can be synthesized through various methods, such as the reduction of 4-nitrobenzaldehyde with lithium aluminum hydride. It is a versatile building block in organic synthesis, particularly for the preparation of pharmaceuticals, agrochemicals, and dyes. It has been studied for its potential applications in the synthesis of various compounds, including drugs, catalysts, and materials. 4-Nitrobenzylamine exhibits diverse pharmacological effects, including anti-inflammatory and analgesic properties. Its potential as a therapeutic agent has been explored in various studies. 4-Nitrobenzylamine is also used in research to investigate the mechanism of action of different enzymes and to study the properties of different materials.'

4-nitrobenzylamine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID29147
CHEMBL ID1235374
SCHEMBL ID354332
SCHEMBL ID7184196
MeSH IDM0140134

Synonyms (28)

Synonym
CHEMBL1235374 ,
pnz ,
p-nitro-benzylamine
AKOS000197746
4-nitrobenzylamine
(4-nitrophenyl)methanamine
7409-30-5
EN300-50135
benzenemethanamine, 4-nitro-
para-nitrobenzylamine
1-((4-nitrophenyl))methanamine
AE-848/32507008
SCHEMBL354332
DTXSID50224996
SCHEMBL7184196
benzenemethanamine,4-nitro-
4-nitro-benzylamine
(4-nitro-benzyl)-amine
4-nitrobenzyl amine
p-nitrobenzylamine
BS-13465
1-(4-nitrophenyl)methanamine
mfcd03411004
Q26840730
AMY20744
D82304
bdbm50232698
SB76597
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Lysyl oxidase homolog 2Homo sapiens (human)IC50 (µMol)0.71900.06600.56494.2600AID1430567
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (15)

Processvia Protein(s)Taxonomy
negative regulation of transcription by RNA polymerase IILysyl oxidase homolog 2Homo sapiens (human)
response to hypoxiaLysyl oxidase homolog 2Homo sapiens (human)
epithelial to mesenchymal transitionLysyl oxidase homolog 2Homo sapiens (human)
endothelial cell proliferationLysyl oxidase homolog 2Homo sapiens (human)
sprouting angiogenesisLysyl oxidase homolog 2Homo sapiens (human)
positive regulation of epithelial to mesenchymal transitionLysyl oxidase homolog 2Homo sapiens (human)
peptidyl-lysine oxidationLysyl oxidase homolog 2Homo sapiens (human)
collagen fibril organizationLysyl oxidase homolog 2Homo sapiens (human)
positive regulation of chondrocyte differentiationLysyl oxidase homolog 2Homo sapiens (human)
protein modification processLysyl oxidase homolog 2Homo sapiens (human)
endothelial cell migrationLysyl oxidase homolog 2Homo sapiens (human)
negative regulation of DNA-templated transcriptionLysyl oxidase homolog 2Homo sapiens (human)
response to copper ionLysyl oxidase homolog 2Homo sapiens (human)
heterochromatin organizationLysyl oxidase homolog 2Homo sapiens (human)
negative regulation of stem cell population maintenanceLysyl oxidase homolog 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
protein-lysine 6-oxidase activityLysyl oxidase homolog 2Homo sapiens (human)
copper ion bindingLysyl oxidase homolog 2Homo sapiens (human)
calcium ion bindingLysyl oxidase homolog 2Homo sapiens (human)
protein bindingLysyl oxidase homolog 2Homo sapiens (human)
oligosaccharide bindingLysyl oxidase homolog 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
collagen-containing extracellular matrixLysyl oxidase homolog 2Homo sapiens (human)
basement membraneLysyl oxidase homolog 2Homo sapiens (human)
extracellular spaceLysyl oxidase homolog 2Homo sapiens (human)
nucleusLysyl oxidase homolog 2Homo sapiens (human)
nucleoplasmLysyl oxidase homolog 2Homo sapiens (human)
endoplasmic reticulumLysyl oxidase homolog 2Homo sapiens (human)
membraneLysyl oxidase homolog 2Homo sapiens (human)
collagen-containing extracellular matrixLysyl oxidase homolog 2Homo sapiens (human)
chromatinLysyl oxidase homolog 2Homo sapiens (human)
collagen-containing extracellular matrixLysyl oxidase homolog 2Homo sapiens (human)
extracellular spaceLysyl oxidase homolog 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1430567Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated for 2 hrs followed by substrate addition measured every 2 minutes for 50 minutes by Amplex red dye based 2017ACS medicinal chemistry letters, Apr-13, Volume: 8, Issue:4
Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.39 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index25.55 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]