4-Methylumbelliferyl-N-acetyl-beta-D-galactosaminide (MUG) is a fluorogenic substrate for beta-galactosidase. MUG is a synthetic compound that is used as a substrate to detect and measure the activity of beta-galactosidase, an enzyme that hydrolyzes lactose into glucose and galactose. It is widely used in research and diagnostics, particularly in the study of bacteria, cell biology, and cancer. MUG is hydrolyzed by beta-galactosidase, producing 4-methylumbelliferone, which is a highly fluorescent compound. The fluorescence intensity of 4-methylumbelliferone is directly proportional to the activity of beta-galactosidase. This makes MUG a very sensitive and accurate substrate for measuring beta-galactosidase activity. MUG is also used in the development of diagnostic kits for various diseases such as bacterial infections, genetic disorders, and cancer.'
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| ID Source | ID |
|---|---|
| PubMed CID | 118328 |
| SCHEMBL ID | 24519625 |
| MeSH ID | M0122957 |
| Synonym |
|---|
| 4-methylumbelliferyl n-acetyl-beta-d-galactosaminide, >=98% (hplc) |
| 4-methylumbelliferyl-n-acetyl-alpha-d-glucosaminide |
| 4-methylumbelliferyl-n-acetyl-beta-d-galactosaminide |
| AKOS000647245 |
| n-[4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]acetamide |
| n-[(2s,3r,4r,5r,6r)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]acetamide |
| n-[(2s,3r,4r,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]acetamide |
| 2h-1-benzopyran-2-one, 7-((2-(acetylamino)-2-deoxy-beta-d-galactopyranosyl)oxy)-4-methyl-, (s-(r*,r*))- |
| 4-methylumbelliferyl-n-acetylamino-beta-galactoside |
| einecs 253-052-3 |
| 7-((2-acetamido-2-deoxy-beta-d-galactopyranosyl)oxy)-4-methyl-2h-1-benzopyran-2-one |
| FT-0672313 |
| 4-methylumbelliferyl n-acetyl-beta-d-glucosaminide |
| FT-0619141 |
| FT-0600190 |
| FT-0619142 |
| mfcd00065481 |
| SR-01000315918-1 |
| sr-01000315918 |
| SY064369 |
| QCTHLCFVVACBSA-UHFFFAOYSA-N |
| M3030 |
| M3029 |
| SB48338 |
| PD080450 |
| SCHEMBL24519625 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||