Page last updated: 2024-12-07

4-methylumbelliferyl heptanoate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

4-methylumbelliferyl heptanoate is a synthetic substrate used to assay the activity of various enzymes, including lipases and esterases. It is a fluorescent compound, meaning it emits light when exposed to ultraviolet radiation. When the ester bond in 4-methylumbelliferyl heptanoate is cleaved by an enzyme, the resulting product, 4-methylumbelliferone, is also fluorescent but exhibits a different emission wavelength. This difference in fluorescence can be measured using a fluorometer, allowing for the quantification of enzyme activity. The synthesis of 4-methylumbelliferyl heptanoate involves the reaction of 4-methylumbelliferone with heptanoic acid in the presence of a suitable coupling reagent. The compound has been used in research to study the activity of lipases from various sources, including pancreatic lipase, bacterial lipases, and fungal lipases. It has also been used to assay the activity of esterases, which are enzymes that hydrolyze ester bonds. The use of 4-methylumbelliferyl heptanoate as a substrate for enzyme assays is advantageous due to its high sensitivity and specificity. It is a widely used and reliable tool in enzyme research and diagnostics.'

Cross-References

ID SourceID
PubMed CID87583
SCHEMBL ID381723
MeSH IDM0153334

Synonyms (28)

Synonym
4-methylumbelliferyl heptanoate, >=95% (gc)
4-methylumbelliferone heptanoate
4-methyl-2-oxo-2h-chromen-7-yl heptanoate
18319-92-1
bdbm24568
4-methylumbelliferyl heptanoate (4-muh)
heptanoic acid, 4-methyl-2-oxo-2h-1-benzopyran-7-yl ester
4-methylumbelliferyl heptanoate
M-5715
FT-0660632
(4-methyl-2-oxochromen-7-yl) heptanoate
einecs 242-207-0
4-methyl-2-oxo-2h-1-benzopyran-7-yl heptanoate
heptanoic acid, ester with 7-hydroxy-4-methylcoumarin
4-methylumbelliferylenanthate
heptanoic acid 4-methylumbelliferyl ester
4-methylumbelliferyl enanthate
AKOS015916460
DTXSID1066362
SCHEMBL381723
J-100223
mfcd00037611
AS-70498
heptanoic acid,4-methyl-2-oxo-2h-1-benzopyran-7-yl ester
l-pca-na
AMY41733
4-methyl-2-oxo-2h-chromen-7-ylheptanoate
PD194713
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (57.14)18.7374
1990's2 (28.57)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.57 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]