4-methylcyclophosphamide profile

4-methylcyclophosphamide is an alkylating agent with anti-cancer properties. It is a prodrug that is metabolized to an active form, 4-hydroxycyclophosphamide, which is a potent inhibitor of DNA synthesis. 4-methylcyclophosphamide is used to treat a variety of cancers, including leukemia, lymphoma, and multiple myeloma. It is also used to suppress the immune system in patients with autoimmune diseases. 4-methylcyclophosphamide is typically administered intravenously or orally. Common side effects include nausea, vomiting, hair loss, and bone marrow suppression. In research, 4-methylcyclophosphamide is studied for its potential to treat a variety of conditions, including cancer, autoimmune diseases, and viral infections. It is also being investigated as a potential agent for tissue regeneration and stem cell therapy.'

4-methylcyclophosphamide: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	119485
SCHEMBL ID	17899474
MeSH ID	M0063380

Synonyms (14)

Synonym
4-methylcyclophosphamide
2h-1,3,2-oxazaphosphorin-2-amine, n,n-bis(2-chloroethyl)tetrahydro-4-methyl-, 2-oxide
b 699
2h-1,3,2-oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-4-methyl-, 2-oxide
tetrahydro-2-(bis(2-chloroethyl)amino)-4-methyl-2h-1,3,2-oxazaphosphorine 2-oxide
57604-37-2
2h-1,2-oxazaphosphorin-2-amine, n,n-bis(2-chloroethyl)tetrahydro-4-methyl-, 2-oxide, trans-
nsc-241532
nsc241532
52663-82-8
SCHEMBL17899474
2-[bis(2-chloroethyl)amino]-4-methyl-1,3,2lambda~5~-oxazaphosphinan-2-one
DTXSID60967089
n,n-bis(2-chloroethyl)-4-methyl-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
"Cyclophosphamide (CP) is selectively toxic to avian and mammalian B lymphocytes, but the mechanisms of action are incompletely understood."	( Cytogenetic mechanisms in the selective toxicity of cyclophosphamide analogs and metabolites towards avian embryonic B lymphocytes in vivo. Bloom, SE; Colvin, OM; Wilmer, JL, 1992)	0.28

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (60.00)	18.7374
1990's	2 (40.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.60 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.39 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.60)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ifosfamide [no description available]	1.98	1	ifosfamides	alkylating agent; antineoplastic agent; environmental contaminant; immunosuppressive agent; xenobiotic
cyanides Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.	1.96	1	pseudohalide anion	EC 1.9.3.1 (cytochrome c oxidase) inhibitor
phosphoramide mustard [no description available]	1.98	1	nitrogen mustard; phosphorodiamide
n,n-diethylcyclophosphamide N,N-diethylcyclophosphamide: structure given in first source	1.98	1
aldophosphamide aldophosphamide: metabolite of cyclophosphamide	1.96	1	nitrogen mustard

Condition	Indicated	Relationship Strength	Studies	Trials
Carcinoma 256, Walker A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)	0	1.95	1	0
Leukemia L 1210 [description not available]	0	1.96	1	0

4-methylcyclophosphamide

Description