4-methylcyclohexanemethanol: a foul-smelling water pollutant [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
4-methylcyclohexanemethanol : An alicyclic primary alcohol that is cyclohexane substituted by a hydroxy methyl group and methyl group at positions 1 and 4. It acts as a hydrotrope, solubilizing hydrophobic substances in aqueous environments. It also prevents protein aggregation, alters membrane dynamics and metal homeostasis, and is used in a flotation process for cleaning and processing coal. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 118193 |
| CHEMBL ID | 3184778 |
| CHEBI ID | 157744 |
| SCHEMBL ID | 155951 |
| SCHEMBL ID | 3485266 |
| SCHEMBL ID | 13755133 |
| SCHEMBL ID | 8216437 |
| SCHEMBL ID | 13164699 |
| Synonym |
|---|
| 4-methylcyclohexanemethanol |
| 4-methylcyclohexane methanol |
| hexahydro-p-tolyl-carbinol |
| 4-methylcyclohexylcarbinol |
| 4-methylcyclohexylmethanol |
| p-methylcyclohexanemethanol |
| mchm |
| 4-methylcyclohexyl-1-carbinol |
| 4-methylcyclohexane-1-methanol |
| (4-methylcyclohexyl)methanol |
| 4-mchm |
| CHEBI:157744 |
| FT-0692545 |
| 34885-03-5 |
| M1412 |
| 4-methyl-1-cyclohexanemethanol |
| 1-(hydroxymethyl)-4-methylcyclohexane |
| AKOS009158915 |
| cas-34885-03-5 |
| dtxcid7021813 |
| tox21_301528 |
| NCGC00255649-01 |
| dtxsid9041813 , |
| unii-1558k6rhm3 |
| ai3-28423 |
| hexahydro-p-methylbenzyl alcohol |
| cyclohexanemethanol, 4-methyl- |
| hsdb 8182 |
| 1558k6rhm3 , |
| cyclohexanemethanol, 4-methyl-, trans- |
| 3937-49-3 |
| OSINZLLLLCUKJH-UHFFFAOYSA-N |
| SCHEMBL155951 |
| SCHEMBL3485266 |
| (trans-4-methylcyclohexyl)methanol |
| trans-(4-methylcyclohexyl)methanol |
| SCHEMBL13755133 |
| cis-4-methylcyclohexanemethanol |
| OSINZLLLLCUKJH-OCAPTIKFSA-N |
| (4-methylcyclohexyl)methanol, (z)- |
| trans-4-methylcyclohexanemethanol |
| cyclohexanemethanol, 4-methyl-, cis- |
| SCHEMBL8216437 |
| SCHEMBL13164699 |
| CHEMBL3184778 |
| 4-methylcyclohexanemethanol, cis- |
| 3937-48-2 |
| 4-methylcyclohexanemethanol, trans- |
| 64PJK2GTXA , |
| 9TEH6BZ70K , |
| unii-64pjk2gtxa |
| unii-9teh6bz70k |
| mfcd00152628 |
| trans-4-methyl-1-cyclohexanemethanol |
| mfcd27997499 |
| AS-59463 |
| P18076 |
| CS-0035799 |
| ((1r,4r)-4-methylcyclohexyl)methanol |
| DTXSID40274142 |
| cis-4-methyl-1-(hydroxymethyl)cyclohexane |
| (cis-4-methylcyclohexyl)methanol |
| DTXSID80274141 |
| CS-0205309 |
| ZB1702 |
| [cis-4-methylcyclohexyl]methanol |
| Q15622250 |
| AM9715 |
| (1alpha,4alpha)-1-hydroxymethyl-4-methylcyclohexane |
| Q27273174 |
| Q27263773 |
| D91499 |
| (1a,4a)-1-hydroxymethyl-4-methylcyclohexane |
| AS-79175 |
| BS-41685 |
| EN300-135109 |
| SB84063 |
| SB84581 |
| CS-0185316 |
| A1-48509 |
| [(1r,4r)-4-methylcyclohexyl]methanol |
| EN300-6982689 |
| SY127924 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Following the spill, the Centers for Disease Control and Prevention recommended a short-term health advisory level of 1 ppm for drinking water that it determined was unlikely to be associated with adverse health effects." | ( The toxicity of crude 4-methylcyclohexanemethanol (MCHM): review of experimental data and results of predictive models for its constituents and a putative metabolite. Green, SM; Novick, RM; Paustenbach, DJ; Winans, B, 2015) | 0.73 |
| " These findings highlight the importance of examining co-exposures to fully understand the potential toxic effects." | ( In vitro cytotoxicity assessment of a West Virginia chemical spill mixture involving 4-methylcyclohexanemethanol and propylene glycol phenyl ether. Boyd, J; Fabyanic, EB; Han, AA; Miller, JV; Mouch, JA; Prediger, MS; Prince, N, 2017) | 0.68 |
| Class | Description |
|---|---|
| aliphatic alcohol | An alcohol derived from an aliphatic compound. |
| primary alcohol | A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. |
| carbocyclic compound | A homocyclic compound in which all of the ring members are carbon atoms. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 5.6910 | 0.0002 | 21.2231 | 8,912.5098 | AID743036 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 28.5224 | 0.0002 | 14.3764 | 60.0339 | AID720692 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 79.7061 | 0.0030 | 41.6115 | 22,387.1992 | AID1159553 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 28.2808 | 0.0002 | 29.3054 | 16,493.5996 | AID743079 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 17 (89.47) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (29.38) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (4.55%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 21 (95.45%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||