Page last updated: 2024-12-06

4-methyl-7-ethoxycoumarin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

4-methyl-7-ethoxycoumarin is a coumarin derivative that has been studied for its potential biological activities. It has been shown to exhibit antioxidant, anti-inflammatory, and antimicrobial properties. The compound is synthesized through various methods, including the Pechmann condensation reaction, which involves the condensation of resorcinol with ethyl acetoacetate. Research on 4-methyl-7-ethoxycoumarin is driven by its potential applications in medicine and agriculture. Its antioxidant activity is of particular interest, as it may be beneficial in protecting against oxidative stress-related diseases. The compound is also being investigated as a potential antifungal agent. The studies on 4-methyl-7-ethoxycoumarin are ongoing, and further research is needed to fully understand its properties and potential therapeutic uses.'

Cross-References

ID SourceID
PubMed CID66595
CHEMBL ID1982193
CHEBI ID169008
SCHEMBL ID66273
MeSH IDM0298399

Synonyms (50)

Synonym
AKOS005446873
7-ethoxy-4-methylchromen-2-one
CHEBI:169008
7-ethoxy-4-methyl-2h-1-benzopyran-2-one
NCI60_004642
87-05-8
coumarin, 7-ethoxy-4-methyl-
4-methyl-7-ethoxycoumarin
7-ethoxy-4-methylcoumarin
nsc60561
2h-1-benzopyran-2-one, 7-ethoxy-4-methyl-
nsc-60561
7-ethoxy-4-methyl-chromen-2-one
7-ethoxy-4-methyl-2h-chromen-2-one
7-ethoxy-4-methylcoumarin, 98%
STK374266
7-ethoxy-4-methylcoumarin, suitable for fluorescence, >=90% (tlc)
HMS1668E09
E0491
ST060225
ai3-08086
nsc 60561
zlv1s0nnzh ,
einecs 201-721-5
unii-zlv1s0nnzh
FT-0621402
SCHEMBL66273
PS-5273
DTXSID3058953
NKRISXMDKXBVRJ-UHFFFAOYSA-N
7-ethoxy-4-methyl-2h-chromen-2-one #
J-100141
CHEMBL1982193
4-methylumbelliferone ethyl ether
mfcd00016971
Z53836590
ethyl 4-methylumbelliferyl ether
ethoxy resocyanin
maraniol
coumarin, 7-ethoxy-4-methyl- (8ci)
7-ethoxy-4-methyl-coumarin
madescol
Q27295711
7-ethoxy-4-methyl-2h-a-benzopyran-2-one
D90531
7-ethoxy-4-methylcoumarin 100 microg/ml in acetonitrile
PD044698
CS-0010002
HY-D0092
EN300-7387782
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
coumarins
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1666538Half life in human liver microsomes at 1 uM measured up to 120 mins in presence of NADPH by LC/MS analysis2020Bioorganic & medicinal chemistry, 02-15, Volume: 28, Issue:4
Identification of potent pyrazole based APELIN receptor (APJ) agonists.
AID1138894Antiasthamic activity in Wistar rat tracheal ring assessed as reversal of carbachol-induced contraction2014European journal of medicinal chemistry, Apr-22, Volume: 77Semisynthesis, ex vivo evaluation, and SAR studies of coumarin derivatives as potential antiasthmatic drugs.
AID1138893Antiasthamic activity in Wistar rat tracheal ring assessed as reversal of carbachol-induced contraction at 0.1 to 500 uM relative to control2014European journal of medicinal chemistry, Apr-22, Volume: 77Semisynthesis, ex vivo evaluation, and SAR studies of coumarin derivatives as potential antiasthmatic drugs.
AID1666539Intrinsic clearance in human liver microsomes at 1 uM measured upto 120 mins in presence of NADPH by LC-MS/MS analysis2020Bioorganic & medicinal chemistry, 02-15, Volume: 28, Issue:4
Identification of potent pyrazole based APELIN receptor (APJ) agonists.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's0 (0.00)29.6817
2010's6 (66.67)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.05 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.35 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]