4-methyl-3-hydroxyanthranilic acid

Description

4-Methyl-3-hydroxyanthranilic acid (4M3HA) is an important intermediate in the biosynthesis of the vitamin riboflavin. It is synthesized from chorismate by the enzyme 4-methyl-3-hydroxyanthranilate synthase (Mhas). 4M3HA is also a substrate for the enzyme riboflavin synthase, which catalyzes the final step in riboflavin biosynthesis. The importance of 4M3HA lies in its role as a precursor to riboflavin, an essential nutrient for human health. Riboflavin is a coenzyme for several important metabolic enzymes, including those involved in energy production, DNA synthesis, and red blood cell formation. Deficiencies in riboflavin can lead to a variety of health problems. Research on 4M3HA focuses on understanding its role in riboflavin biosynthesis, developing methods for its synthesis, and exploring its potential as a therapeutic agent. 4M3HA has been shown to have antioxidant and anti-inflammatory properties. However, further research is needed to determine its safety and efficacy as a therapeutic agent.'

4-methyl-3-hydroxyanthranilic acid: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

3-hydroxy-4-methylanthranilic acid : An aminobenzoic acid that is anthranilic acid substituted by a hydroxy group at position 3 and a methyl group at position 4. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]