4-hydroxypanduratin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-hydroxypanduratin A: putative skin-whitening agent; isolated from Kaempferia pandurata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Kaempferia	genus	[no description available]	Zingiberaceae	A plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).[MeSH]

Cross-References

ID Source	ID
PubMed CID	636530
CHEMBL ID	210882
MeSH ID	M0516788

Synonyms (13)

Synonym
[(1r,2s,6r)-3-methyl-2-(3-methylbut-2-enyl)-6-phenyl-cyclohex-3-en-1-yl]-(2,4,6-trihydroxyphenyl)methanone
methanone, (2,4,6-trihydroxyphenyl)[(1r,2s,6r)-3-methyl-2-(3-methyl-2-butenyl)-6-phenyl-3-cyclohexen-1-yl]-
hydroxypanduratin a
(-)-hydroxypanduratin a
rel-[(1r,2s,6r)-3-methyl-2-(3-methylbut-2-en-1-yl)-6-phenylcyclohex-3-en-1-yl](2,4,6-trihydroxyphenyl)methanone
[3-methyl-2-(3-methyl-but-2-enyl)-6-phenyl-cyclohex-3-enyl]-(2,4,6-trihydroxy-phenyl)-methanone
(-)-(2,4,6-trihydroxyphenyl)[3'-methyl-2'-(3''-methylbut-2''-enyl)-6'-phenylcyclohex-3'-enyl]methanone
inchi=1/c25h28o4/c1-15(2)9-11-19-16(3)10-12-20(17-7-5-4-6-8-17)23(19)25(29)24-21(27)13-18(26)14-22(24)28/h4-10,13-14,19-20,23,26-28h,11-12h2,1-3h3/t19-,20+,23-/m1/s
methanone, [(1r,2s,6r)-3-methyl-2-(3-methyl-2-butenyl)-6-phenyl-3-cyclohexen-1-yl](2,4,6-trihydroxyphenyl)-
bdbm50185447
CHEMBL210882 ,
4-hydroxypanduratin a
[(1r,2s,6r)-3-methyl-2-(3-methylbut-2-enyl)-6-phenylcyclohex-3-en-1-yl]-(2,4,6-trihydroxyphenyl)methanone

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Genome polyprotein	Dengue virus 2 Thailand/16681/84	Ki	21.0000	5.8000	5.8000	5.8000	AID265726
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay ID	Title	Year	Journal	Article
AID265718	Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 80 ppm	2006	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12	Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
AID265724	Inhibition of dengue2 virus NS2B/NS3 protease activity for Ac-Thr-Arg-Arg-MCA cleavage at 240 ppm	2006	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12	Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
AID265723	Inhibition of dengue2 virus NS2B/NS3 protease activity for Ac-Thr-Arg-Arg-MCA cleavage at 120 ppm	2006	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12	Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
AID311568	Cytotoxicity against human PANC1 cells assessed as cell viability	2007	Journal of natural products, Oct, Volume: 70, Issue:10	Bioactive secondary metabolites from Boesenbergia pandurata of Myanmar and their preferential cytotoxicity against human pancreatic cancer PANC-1 cell line in nutrient-deprived medium.
AID1438026	Cytotoxicity against human PANC1 cells in DMEM measured after 24 hrs by WST8 assay
AID265717	Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 40 ppm	2006	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12	Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
AID1438024	Antiausteritic activity against human PANC1 cells in nutrient-deprived medium measured after 24 hrs by WST8 assay
AID265719	Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 120 ppm	2006	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12	Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
AID265726	Inhibition of dengue2 virus NS3 protease	2006	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12	Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
AID265720	Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 160 ppm	2006	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12	Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
AID265722	Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 400 ppm	2006	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12	Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
AID265721	Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 240 ppm	2006	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12	Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
AID265725	Inhibition of dengue2 virus NS2B/NS3 protease activity for Ac-Thr-Arg-Arg-MCA cleavage at 400 ppm	2006	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12	Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	3 (42.86)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.29 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.37 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.29)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.03	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
arctigenin arctigenin: precursor to catechols; in many plants	2.03	1	lignan
pinocembrin pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.	2.44	2	(2S)-flavan-4-one; dihydroxyflavanone	antineoplastic agent; antioxidant; metabolite; neuroprotective agent; vasodilator agent
pinostrobin [no description available]	2.44	2	monohydroxyflavanone; monomethoxyflavanone	antidote; plant metabolite
cardamonin cardamonin: found in Zingiberaceae; structure in first source	2.44	2	chalcones
phenylthiourea Phenylthiourea: Phenylthiourea is a THIOUREA derivative containing a phenyl ring. Depending on their genetic makeup, humans can find it either bitter-tasting or tasteless.. N-phenylthiourea : A member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a phenyl group. Depending on their genetic makeup, humans find it either very bitter-tasting or tasteless. This unusual property resulted in N-phenylthiourea being used in paternity testing prior to the advent of DNA testing.	2.03	1	thioureas	EC 1.14.18.1 (tyrosinase) inhibitor
5,6-dehydrokawain 5,6-dehydrokawain: from Alpinia speciosa rhizoma; RN given for cpd without isomeric designation; structure given in first source	2.03	1	2-pyranones; aromatic ether
tectochrysin tectochrysin: structure in first source. tectochrysin : A monohydroxyflavone that is flavone substituted by a hydroxy group at position 4 and a methoxy group at position 7 respectively.	2.03	1	monohydroxyflavone; monomethoxyflavone	antidiarrhoeal drug; antineoplastic agent; plant metabolite
flavokawain C flavokawain C: antineoplastic from roots of Kava (Piper methysticum Forst); structure in first source	2.03	1	chalcones
panduratin a panduratin A: isolated from Kaempferia pandurata; structure in first source	2.74	3	diarylheptanoid	metabolite
isopanduratin a isopanduratin A: isolated from Kaempferia pandurata; structure in first source	2.76	3

Condition	Relationship Strength	Studies
Cancer of Pancreas [description not available]	2.03	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.03	1
Lung Adenocarcinoma [description not available]	7.21	1
Cancer of Lung [description not available]	2.21	1
Adenocarcinoma of Lung A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.	2.21	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.21	1
Break-Bone Fever [description not available]	2.1	1
Dengue An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.	2.1	1
Skin Aging The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.	2.05	1

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