Compounds > 4-hydrazinoquinazoline
Page last updated: 2024-12-06

4-hydrazinoquinazoline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

4-hydrazinoquinazoline is a heterocyclic compound that has been investigated for its potential medicinal properties. It has been shown to exhibit anti-cancer activity against various cancer cell lines, including breast, lung, and colon cancer cells. The compound has been synthesized through various methods, including the reaction of 4-chloroquinazoline with hydrazine hydrate. Studies have shown that 4-hydrazinoquinazoline can inhibit the growth of cancer cells by interfering with DNA synthesis and cell cycle progression. This compound is also being explored for its potential anti-inflammatory and anti-microbial activities. The ability of 4-hydrazinoquinazoline to act as a scaffold for the synthesis of diverse quinazoline derivatives has further fueled research into its potential therapeutic applications. Researchers are actively investigating its mechanism of action and its potential as a lead compound for the development of novel drugs.'

Cross-References

ID SourceID
PubMed CID63343
SCHEMBL ID3874722
MeSH IDM0226546

Synonyms (24)

Synonym
AKOS001104855
4-hydrazinoquinazoline
quinazolin-4-ylhydrazine
HMS1745I18
1-(quinazolin-4-yl)hydrazine
A18687
36075-44-2
4(1h)-quinazolinone, hydrazone
ks 79
FT-0681185
4-hydrazinylquinazoline
SCHEMBL3874722
LB-0817
quinazolin-4-yl-hydrazine
J-515460
4-hydrazinoquinazoline, aldrichcpr
DTXSID80189660
mfcd01219546
SY038179
CS-0084747
F1070-0001
AC5998
EN300-76390
Z57161623
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (83.33)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.92 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.92)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		2.0610azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
hydrazine
diamine : Any polyamine that contains two amino groups.		3.0240azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
galactose
aldohexose : A hexose with a (potential) aldehyde group at one end.		2.0610
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.0810organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Injury, Myocardial Reperfusion
[description not available]		02.0810