Compounds > 4-ethyl-1-phospha-2,6,7 trioxabicyclo(2.2.2)octane-1-oxide
Page last updated: 2024-12-05

4-ethyl-1-phospha-2,6,7 trioxabicyclo(2.2.2)octane-1-oxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID13869
SCHEMBL ID813272
MeSH IDM0180153

Synonyms (56)

Synonym
4-aethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2)octan-1-oxid
2,6,7-trioxa-1-phosphabicyclo-(2.2.2)octane, 4-ethyl-, 1-oxide
nsc 72890
2,6,7-trioxa-1-phosphabicyclo-[2.2.2]octane, 4-ethyl-, 1-oxide
4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxide
2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane, 4-ethyl-, 1-oxide
1005-93-2
nsc-72890
1, 2-ethyl-2-(hydroxymethyl)-, cyclic phosphate
trimethylolpropane phosphate
nsc72890
2,7-trioxa-1-phosphabicyclo[2.2.2]octane, 4-ethyl-, 1-oxide
wln: t4ptj ao bq c2q c1 dq
1, 2-ethyl-2-(hydroxymethyl)-, cyclic phosphate (1:1)
2-ethyl-2-(hydroxymethyl)-1,3-propanediol cyclic phosphate (1:1)
4-ethyl-1-phospha-2,7-trioxabicyclo[2.2.2]octane 1-oxide
4-aethyl-1-phospha-2,7-trioxabicyclo[2.2.2]octan 1-oxid
4-ethyl-2,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxide
einecs 213-740-6
trimethylopropane phosphate
trimethyolpropane phosphate
2-ethyl-2-(hydroxymethyl)-1,3-propanediol, cyclic phosphate (1:1)
2,6,7-trioxa-1-phosphabicyclo(2.2.2)octane, 4-ethyl-, 1-oxide
4-ethyl-1-phospha-2,6,7 trioxabicyclo(2.2.2)octane-1-oxide
4-ethyl-2,6,7-trioxa-1-phosphabicyclo(2.2.2)octane 1-oxide
tmp-p
1-ethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2)octane-1-oxide
4-ethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2.)octane-1-oxide
1-ethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2)octane 1-oxide
2-(hydroxymethyl)-2-ethyl-1,3-propanediol, cyclic phosphate (1:1)
4-ethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2)octane-1-oxide
1,3-propanediol, 2-ethyl-2-(hydroxymethyl)-, cyclic phosphate
brn 1909748
4-aethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2)octan-1-oxid [german]
4-ethyl-2,6,7-trioxa-1-phosphabicyclo(2.2.2)octane-1-oxide
ethyl bicyclic phosphate
etbicyphat
AKOS006272342
FT-0626165
1,1,1-trimethylolpropane phosphate
SCHEMBL813272
BYEFHDZWRALTEN-UHFFFAOYSA-N
DTXSID5058270
mfcd00043597
J-000170
4-ethyl-2,6,7-trioxa-1-phosphabicy-clo[2.2.2]octane 1-oxide
etbicyphat, >=95% (nmr), solid
4-ethyl-2,6,7-trioxa-1lambda5-phosphabicyclo[2.2.2]octane 1-oxide
4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane-1-oxide
4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxide.
F82933
HY-139145
STARBLD0009575
BAA00593
trimethylolpropane (1,3,5-13c3) phosphate
4-ethyl-2,6,7-trioxa-1|e?-phosphabicyclo[2.2.2]octan-1-one

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" They showed no toxic cumulative effects."( Acute toxicity of bicyclic phosphorus esters.
Eben, A; Gröning, P; Kimmerle, G; Thyssen, J, 1976)		0.26

Dosage Studied

ExcerptRelevanceReference
" Parallel dose-response curves suggest that TMPP acts by a competitive antagonism of GABA inhibition, and are consistent with reported patch-clamp analysis of TMPP-induced reduction of inhibitory postsynaptic current amplitudes."( Characterization of acute neurotoxic effects of trimethylolpropane phosphate via neuronal network biosensors.
Gramowski, A; Gross, GW; Keefer, EW; Pancrazio, JJ; Stenger, DA, 2001)		0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.26)18.7374
1990's8 (42.11)18.2507
2000's8 (42.11)29.6817
2010's2 (10.53)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.15 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index5.20 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gamma-aminobutyric acid
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.		210amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		1.9710halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
salicylic acid
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).		2.0210monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
acetaminophen
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.. paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.		2.0210acetamides;
phenols		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
baclofen
[no description available]		210amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid;
monochlorobenzenes;
primary amino compound		central nervous system depressant;
GABA agonist;
muscle relaxant
diazepam
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.		2101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
muscimol
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.. muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.		210alkaloid;
isoxazoles;
primary amino compound		fungal metabolite;
GABA agonist;
oneirogen;
psychotropic drug
fg 7142
FG 7142: benzodiazepine receptor agonist		1.9910beta-carbolines
thyroxine
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.		2.1102-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
pentylenetetrazole
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.. pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.		1.9910organic heterobicyclic compound;
organonitrogen heterocyclic compound
flurothyl
Flurothyl: A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.		1.9710ether
bicuculline
Bicuculline: An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.. bicuculline : A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.		2.4120benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane: a flame retardant and androgen receptor agonist; structure in first source		2.110
tert-butylbicyclophosphorothionate
tert-butylbicyclophosphorothionate: binds to GABA & ion recognition sites; structure given in first source		1.9710organic thiophosphate
maleic acid
maleic acid: RN given refers to parent cpd(Z)-isomer which is maleic acid; all RR's given refer to (Z)-isomer; (E)-isomer is fumaric acid. maleic acid : A butenedioic acid in which the double bond has cis- (Z)-configuration.		2.0210butenedioic acidalgal metabolite;
mouse metabolite;
plant metabolite
fumaric acid
fumaric acid: see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters. fumaric acid : A butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.		2.0210butenedioic acidfood acidity regulator;
fundamental metabolite;
geroprotector
sorbic acid
Sorbic Acid: Mold and yeast inhibitor. Used as a fungistatic agent for foods, especially cheeses.. (2E,4E)-hexa-2,4-dienoic acid : A sorbic acid having trans-double bonds at positions 2 and 4; a food preservative that can induce cutaneous vasodilation and stinging upon topical application to humans. It is the most thermodynamically stable of the four possible geometric isomers possible, as well as the one with the highest antimicrobial activity.. sorbic acid : A hexadienoic acid with double bonds at C-2 and C-4; it has four geometrical isomers, of which the trans,trans-form is naturally occurring.		2.0210alpha,beta-unsaturated monocarboxylic acid;
sorbic acid
fumarates
Fumarates: Compounds based on fumaric acid.. fumarate(2-) : A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2-)		2.0210butenedioate;
C4-dicarboxylate		human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite
picrotoxin
Picrotoxin: A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.. picrotoxin : A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure
[description not available]		02.6730
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.6730
Aura
[description not available]		0210
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)		0210
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		0210
Nervous System Disorders
[description not available]		01.9810
Nervous System Diseases
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.		01.9810