| Assay ID | Title | Year | Journal | Article |
|---|
| AID777168 | Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluorescence assay | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21
| Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. |
| AID777167 | Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluorescence assay relative to AMPA | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21
| Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. |
| AID1170667 | Binding affinity to GluA2-LBD-L483Y-N754S complex (unknown origin) by isothermal titration calorimetry | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiad |
| AID1170671 | Positive allosteric modulation of AMPA receptor in rat hippocampal slice assessed as increase in AMPA-mediated presynaptic noradrenaline release | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiad |
| AID1478393 | Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calcium flux by fluo-4/AM dye-based fluorescence assay | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1
| 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. |
| AID1478394 | Induction of dimerization of rat N-terminal His-tagged GluA2-LBD-N775S mutant expressed in Escherichia coli Origami B (DE3) assessed as intrinsic binding constant by small-angle X-ray scattering method | 2018 | Journal of medicinal chemistry, 01-11, Volume: 61, Issue:1
| 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. |
| AID1170670 | Positive allosteric modulation of AMPA receptor in rat embryonic cortex primary neuronal culture assessed as increase in AMPA-induced membrane depolarization by microplate reader | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiad |
| AID1170668 | Potentiation of AMPA receptor in rat embryonic cortex primary neuronal culture assessed as concentration required to 2-fold increase in AMPA-induced membrane depolarization by microplate reader | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiad |
| AID777169 | Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as concentration required to 2 fold increase of AMPA-induced membrane depolarization by fluorescence assay | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21
| Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. |
| AID1170669 | Positive allosteric modulation of AMPA receptor in rat embryonic cortex primary neuronal culture assessed as maximal increase in AMPA-induced membrane depolarization normalized to AMPA-evoked response by microplate reader | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiad |
| AID777162 | Binding affinity to rat LBD of GluA2 receptor L483Y and N754S mutant at 243 uM by isothermal titration calorimetry analysis | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21
| Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21
| Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |