4-aminophenylethyl-1,4,7,10-tetraazacyclodecane-n,n',n'',n'''-tetraacetic acid profile

4-aminophenylethyl-1,4,7,10-tetraazacyclodecane-N,N',N'',N'''-tetraacetic acid: bifunctional chelating agent for radioimmunotherapy studies; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	131254
SCHEMBL ID	6547642
MeSH ID	M0227474

Synonym
4-aminophenylethyl-1,4,7,10-tetraazacyclodecane-n,n',n'',n'''-tetraacetic acid
pa-dota
130707-75-4
1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, alpha-(2-(4-aminophenyl)ethyl)-
alpha-(2-(4-aminophenyl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
4-(4-aminophenyl)-2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]butanoic acid
SCHEMBL6547642
4-(4-aminophenyl)-2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]butanoic acid
DTXSID70926864

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (60.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	2.01	1	pentacarboxylic acid	copper chelator
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	1.98	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
lutetium Lutetium: An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.	3.09	5	d-block element atom; lanthanoid atom
samarium Samarium: An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.	1.98	1	f-block element atom; lanthanoid atom
yttrium radioisotopes Yttrium Radioisotopes: Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.	1.98	1
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid: structure given in first source. DOTA : An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group.	2.01	1	azamacrocycle	chelator; copper chelator
n-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-n,n',n',n'',n''-pentaacetic acid N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid: used for (111)Indium labeling of monoclonal antibodies; structure in J Chem Soc (Perkin 1) 1992:1173-8; RN given refers to ((1alpha(S*),2beta)-(+-))-isomer	2.01	1

Condition	Relationship Strength	Studies
Cancer of Colon [description not available]	2.69	3
Experimental Neoplasms [description not available]	2.01	1
Peritoneal Carcinomatosis [description not available]	2.01	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.69	3
Peritoneal Neoplasms Tumors or cancer of the PERITONEUM.	2.01	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2	1
Colorectal Cancer [description not available]	2	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2	1
Adenocarcinoma, Basal Cell [description not available]	2.01	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.01	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.01	1

4-aminophenylethyl-1,4,7,10-tetraazacyclodecane-n,n',n'',n'''-tetraacetic acid

Description

Cross-References

Synonyms (9)

Research

Studies (5)

Market Indicators

Research Demand Index: 12.50

Study Types