4-aminophenylacetic acid profile

4-aminophenylacetic acid, also known as p-aminophenylacetic acid, is a naturally occurring amino acid that has been found in various plants and microorganisms. It is a precursor to the synthesis of several important compounds, including the neurotransmitter dopamine. The synthesis of 4-aminophenylacetic acid typically involves the reaction of 4-nitrophenylacetic acid with a reducing agent, such as iron or tin. The resulting 4-aminophenylacetic acid can then be used as a starting material for the production of other pharmaceuticals. 4-aminophenylacetic acid has been studied for its potential therapeutic applications, particularly in the treatment of Parkinson's disease. It is also used as an intermediate in the synthesis of several other drugs and chemicals. Its importance in research lies in its role as a precursor to dopamine and its potential to serve as a therapeutic agent.'

4-aminophenylacetic acid: peptide mimic; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	14533
CHEMBL ID	3278327
SCHEMBL ID	39103
MeSH ID	M0285128

Synonym
BB 0244247
(4-amino-phenyl)-acetic acid
2-(4-aminophenyl)-acetic acid
acetic acid, (p-aminophenyl)-
p-aminophenylacetic acid
(para-aminophenyl)acetic acid
4-aminobenzeneacetic acid
nsc-7929
4-aminophenylacetic acid
1197-55-3
benzeneacetic acid, 4-amino-
nsc7929
ccris 3157
nsc 7929
einecs 214-828-7
p-amino-alpha-toluic acid
brn 2208094
4-carboxymethylaniline
OPREA1_658624
(p-aminophenyl)acetic acid
2-(4-aminophenyl)acetic acid
inchi=1/c8h9no2/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4h,5,9h2,(h,10,11
4-aminophenylacetic acid, 98% ,
A0393
AKOS000104762
(4-aminophenyl)acetic acid
STL139160
(4-aminophenyl)acetate
unii-1ied47a544
3-14-00-01182 (beilstein handbook reference)
1ied47a544 ,
FT-0617595
BBL018950
AM20060949
AE-508/40191188
4-(carboxymethyl)aniline
p-amino-.alpha.-toluic acid
p-aminophenylacetic acid [mi]
4-aminophenylaceticacid
CHEMBL3278327
SCHEMBL39103
SY001637
mfcd00007916
DTXSID1061609
2-(4-amino phenyl)-acetic acid
para-aminophenylacetic acid
p-aminophenyl acetic acid
(p-aminophenyl)-acetic acid
4-aminophenyl-acetic acid
4-amino phenyl acetic acid
(4-aminophenyl)-acetic acid
2-(4aminophenyl)acetic acid
4-amino-phenylacetic acid
4-amino-phenyl acetic acid
4-amino-phenyl-acetic acid
(4-amino-phenyl)acetic acid
4-aminobenzene acetic acid
4-amino phenylacetic acid
4-aminophenyl acetic acid
STR03492
BS-3833
4-(aminophenyl)acetic acid
W-108499
bdbm231635
4-aminophenylacetic acid, vetec(tm) reagent grade, 98%
CS-W018535
F0001-0324
BP-24384
BCP24945
Q15726001
AC7503
EN300-20755
Z104481066

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Olfactory receptor class A-like protein 1	Danio rerio (zebrafish)	EC50 (µMol)	91.7000	1.9000	1.9000	1.9000	AID1802885
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID1146772	Dissociation constant, pKa of the compound	1977	Journal of medicinal chemistry, Feb, Volume: 20, Issue:2	P-Aminobenzoic acid derivatives as inhibitors of the cell-free H2-pteroate synthesizing system of Escherichia coli.
AID1146770	Competitive inhibition of Escherichia coli B H2-pteroate synthetase assessed as decrease in H2-pteroate formation using [7-14C]-PABA as substrate treated with enzyme for 10 mins prior to substrate challenge for 40 mins by radioassay method	1977	Journal of medicinal chemistry, Feb, Volume: 20, Issue:2	P-Aminobenzoic acid derivatives as inhibitors of the cell-free H2-pteroate synthesizing system of Escherichia coli.
AID1802885	Functional Calcium Imaging Assay from Article 10.1074/jbc.M114.573162: \\ORA1, a zebrafish olfactory receptor ancestral to all mammalian V1R genes, recognizes 4-hydroxyphenylacetic acid, a putative reproductive pheromone.\\	2014	The Journal of biological chemistry, Jul-11, Volume: 289, Issue:28	ORA1, a zebrafish olfactory receptor ancestral to all mammalian V1R genes, recognizes 4-hydroxyphenylacetic acid, a putative reproductive pheromone.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (18.18)	18.7374
1990's	2 (18.18)	18.2507
2000's	3 (27.27)	29.6817
2010's	3 (27.27)	24.3611
2020's	1 (9.09)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-hydroxyphenylacetic acid 4-hydroxyphenylacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.	2.1	1	monocarboxylic acid; phenols	fungal metabolite; human metabolite; mouse metabolite; plant metabolite
4-hydroxybenzoic acid 4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.	1.95	1	monohydroxybenzoic acid	algal metabolite; plant metabolite
3,4-dihydroxyphenylacetic acid 3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.. (3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.. dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.	2.1	1	catechols; dihydroxyphenylacetic acid	human metabolite
4-aminobenzoic acid 4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.. 4-ammoniobenzoate : A zwitterion obtained by transfer of a proton from the carboxy to the amino group of 4-aminobenzoic acid.. 4-aminobenzoic acid : An aminobenzoic acid in which the amino group is para to the carboxy group.	1.99	1	aminobenzoic acid; aromatic amino-acid zwitterion	allergen; Escherichia coli metabolite; plant metabolite
phenylacetic acid phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.	2.49	2	benzenes; monocarboxylic acid; phenylacetic acids	allergen; Aspergillus metabolite; auxin; EC 6.4.1.1 (pyruvate carboxylase) inhibitor; Escherichia coli metabolite; human metabolite; plant growth retardant; plant metabolite; Saccharomyces cerevisiae metabolite; toxin
p-aminohippuric acid p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.. p-aminohippurate : A hippurate that is the conjugate base of p-aminohippuric acid, arising from deprotonation of the carboxy group.. p-aminohippuric acid : An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.	1.95	1	N-acylglycine	Daphnia magna metabolite
benzocaine Benzocaine: A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS.. dextran sulfate sodium : An organic sodium salt of dextran sulfate. It induces colitis in mice.. benzocaine : A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina.	1.95	1	benzoate ester; substituted aniline	allergen; antipruritic drug; sensitiser; topical anaesthetic
4-aminobenzoic acid para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.. 4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.	1.99	1	aminobenzoate; aromatic amino-acid anion	Escherichia coli metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
procainamide Procainamide: A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.. procainamide : A benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group. It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias.	1.95	1	benzamides	anti-arrhythmia drug; platelet aggregation inhibitor; sodium channel blocker
sulfapyridine Sulfapyridine: Antibacterial, potentially toxic, used to treat certain skin diseases.. sulfapyridine : A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.	2.25	1	pyridines; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; dermatologic drug; drug allergen; environmental contaminant; xenobiotic
aniline [no description available]	1.95	1	anilines; primary arylamine
4-aminopropiophenone 4-aminopropiophenone: RN given refers to parent cpd	1.95	1
4-aminoacetophenone [no description available]	1.95	1
4-toluidine 4-toluidine: RN given refers to parent cpd. p-toluidine : An aminotoluene in which the amino substituent is para to the methyl group.	1.95	1	aminotoluene
hydrazine diamine : Any polyamine that contains two amino groups.	1.93	1	azane; hydrazines	EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
phloretic acid phloretic acid: structure. N-hydroxysuccinimide ester : An ester of N-hydroxysuccinimide.. phloretic acid : A hydroxy monocarboxylic acid consisting of propionic acid having a 4-hydroxyphenyl group at the 3-position.	2.1	1	hydroxy monocarboxylic acid	plant metabolite
methyl 4-aminobenzoate [no description available]	1.95	1
4-chlorophenylacetic acid 4-chlorophenylacetic acid: RN given refers to parent cpd. 4-chlorophenylacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-chlorophenyl group.	2.1	1	monocarboxylic acid; monochlorobenzenes	xenobiotic metabolite
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	2.25	1	elemental platinum; nickel group element atom; platinum group metal atom
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	2.05	1	titanium group element atom
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.51	2	copper group element atom; elemental gold
titanium dioxide titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.	2.05	1	titanium oxides	food colouring
4-aminomethylbenzoic acid [no description available]	1.99	1	benzoic acids
4-aminobenzamide [no description available]	1.95	1	benzamides
4-(hydroxyphenyl)acetamide 4-(hydroxyphenyl)acetamide: structure given in first source; an impurity found in the HPLC assay for atenolol; do not confuse with acetaminophen	2.1	1	acetamides
4-aminobenzoylglutamic acid 4-aminobenzoylglutamic acid: RN given refers to (L)-isomer. N-(4-aminobenzoyl)-L-glutamic acid : A dipeptide resulting from the formal condensation of the carboxylic acid group of 4-aminobenzoic acid with the amino group of L-glutamic acid.	1.95	1	dicarboxylic acid; dipeptide; N-acyl-L-alpha-amino acid; substituted aniline

Condition	Relationship Strength	Studies
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.02	1
Colitis Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.	2.02	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.02	1

4-aminophenylacetic acid

Description

Cross-References

Synonyms (73)

Protein Targets (1)

Activation Measurements

Bioassays (3)

Research

Studies (11)

Market Indicators

Research Demand Index: 28.80

Study Types