Compounds > 4-aminobutyric acid methyl ester
Page last updated: 2024-11-05

4-aminobutyric acid methyl ester

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-aminobutyric acid methyl ester (GABA-ME) is an ester of GABA. It is a prodrug of GABA, meaning that it is converted into GABA in the body. GABA-ME is a potent GABAergic agonist, meaning that it activates GABA receptors in the brain. GABA is the primary inhibitory neurotransmitter in the brain, meaning that it reduces the activity of neurons. GABA-ME has been studied for its potential to treat anxiety, depression, epilepsy, and other neurological disorders. It is also being investigated for its potential to improve cognitive function and memory. GABA-ME can be synthesized by reacting GABA with methanol in the presence of an acid catalyst. GABA-ME is a white, crystalline solid that is soluble in water and ethanol. It is typically administered orally, intravenously, or intramuscularly. GABA-ME has been shown to be effective in treating anxiety and depression in clinical trials. It is also being investigated for its potential to treat other neurological disorders such as epilepsy and Parkinson's disease. GABA-ME is a promising new drug for the treatment of a variety of neurological disorders.'

bradykinin, Met-Ile-Ser-: released from T-kininogen by an acid proteinase of granulomatous tissues in rats [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

methyl 4-aminobutanoate : A methyl ester resulting from the formal condensation of gamma-aminobutyric acid with methanol. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID18614
CHEBI ID42955
SCHEMBL ID380579
MeSH IDM0113975

Synonyms (34)

Synonym
EN300-35518
3251-07-8
brn 0635882
gaba methyl ester
butyric acid, 4-amino-, methyl ester
butanoic acid, 4-amino-, methyl ester
methyl 4-aminobutyrate
4-aminobutyric acid methyl ester
methyl gamma-aminobutyrate
UPCMLD00WMAL386
methyl 4-aminobutanoate
BMSE000249
butanoic acid, 4-amino-, methyl ester (9ci)
HMS1747L19
3-04-00-01316 (beilstein handbook reference)
STL257796
AM803145
bradykinin, met-ile-ser-
110538-07-3
AKOS015859855
methyl-4-aminobutyrate
KVQGGLZHHFGHPU-UHFFFAOYSA-N
4-amino-butyric acid methyl ester
SCHEMBL380579
CHEBI:42955
h-gaba-ome.hcl
h-gamma-abu-ome.hcl
BS-12855
h--abu-ome.hcl
FT-0728794
mfcd00233491
Q27120500
methyl4-aminobutanoate
DTXSID10954242
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
primary amino compoundA compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
amino acid esterAny carboxylic ester derivative of an amino acid.
methyl esterAny carboxylic ester resulting from the formal condensation of a carboxy group with methanol.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (57.14)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.39 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gamma-aminobutyric acid
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.		2.6630amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
sodium azide
Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).		2.0710inorganic sodium saltantibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen
t-kinin
T-kinin: from rat plasma		1.9710peptide
bradykinin
[no description available]		2.3720oligopeptidehuman blood serum metabolite;
vasodilator agent
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Granulomas
[description not available]		02.3720
Granuloma
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.		02.3720
Innate Inflammatory Response
[description not available]		01.9710
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		01.9710