4-(5-nitro-2-furyl)thiazole profile

4-(5-nitro-2-furyl)thiazole is an antimicrobial agent that was once widely used in veterinary medicine. It is a synthetic compound with a nitrofuran moiety, which is known for its antibacterial properties. This compound inhibits bacterial DNA replication and repair processes. However, concerns about its carcinogenicity and potential mutagenicity led to its withdrawal from use in many countries.'
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4-(5-nitro-2-furyl)thiazole: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	107987
MeSH ID	M0092842

Synonym
4-(5-nitro-2-furyl)thiazole
4-(5-nitrofuran-2-yl)-1,3-thiazole
53757-28-1
4-(5-nitro-2-furanyl)thiazole
brn 1076064
thiazole, 4-(5-nitro-2-furanyl)-
thiazole, 4-(5-nitro-2-furyl)-
ccris 1201
AKOS006276491
9p249y2mcb ,
unii-9p249y2mcb
DTXSID4020951
nitro-2-furanyl)thiazole, 4-(5-

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
aspirin Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.	1.96	1	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent
probenecid Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.. probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.	1.96	1	benzoic acids; sulfonamide	uricosuric drug
thiazoles [no description available]	3.35	7	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
fanft FANFT: A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.	3.35	7
nadp [no description available]	1.96	1

Condition	Relationship Strength	Studies
Cancer of Liver [description not available]	1.96	1
Cancer of Stomach [description not available]	1.96	1
Experimental Mammary Neoplasms [description not available]	1.96	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.96	1
Stomach Neoplasms Tumors or cancer of the STOMACH.	1.96	1
Diathesis [description not available]	1.97	1
E coli Infections [description not available]	1.97	1
Innate Inflammatory Response [description not available]	1.97	1
Cancer of the Urinary Tract [description not available]	1.97	1
Cocarcinogenesis The combination of two or more different factors in the production of cancer.	1.97	1
Escherichia coli Infections Infections with bacteria of the species ESCHERICHIA COLI.	1.97	1
Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	1.97	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	1.97	1
Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	1.97	1
Bladder Cancer [description not available]	1.96	1
Carcinoma, Anaplastic [description not available]	1.96	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	1.96	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	1.96	1

4-(5-nitro-2-furyl)thiazole

Description

Cross-References

Synonyms (13)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.37

Study Types