Compounds > 4-(4-chloroanilino)-3-pyridinesulfonamide

Page last updated: 2024-11-09

4-(4-chloroanilino)-3-pyridinesulfonamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	902007
CHEMBL ID	1471166
CHEBI ID	114649

Synonyms (17)

Synonym
HMS2568H12
jdl 167
4-((4-chlorophenyl)amino)-3-pyridinesulfonamide
brn 0416388
3-pyridinesulfonamide, 4-((4-chlorophenyl)amino)-
OPREA1_838745
smr000231066
MLS000704627
4-(4-chloroanilino)-3-pyridinesulfonamide
AJ-333/25006237
CHEBI:114649
4-(4-chloroanilino)pyridine-3-sulfonamide
NCGC00247211-01
56175-92-9
CHEMBL1471166
Q27196053
DTXSID70204710

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
pyridines	Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.
sulfonamide	An amide of a sulfonic acid RS(=O)2NR'2.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
P53	Homo sapiens (human)	Potency	22.3872	0.0731	9.6858	31.6228	AID504706
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	89.1251	0.0355	20.9770	89.1251	AID504332
chromobox protein homolog 1	Homo sapiens (human)	Potency	79.4328	0.0060	26.1688	89.1251	AID540317
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	29.0929	5.8048	36.1306	65.1308	AID540253
snurportin-1	Homo sapiens (human)	Potency	29.0929	5.8048	36.1306	65.1308	AID540253
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	29.0929	5.8048	16.9962	25.9290	AID540253
geminin	Homo sapiens (human)	Potency	0.0052	0.0046	11.3741	33.4983	AID624296
lamin isoform A-delta10	Homo sapiens (human)	Potency	15.8489	0.8913	12.0676	28.1838	AID1487
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)	AC50	30.0000	4.1900	12.0150	18.1100	AID720591
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (12)

Process	via Protein(s)	Taxonomy
protein deacetylation	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
protein deacetylation	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
mitochondrion organization	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
regulation of ketone biosynthetic process	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
negative regulation of cardiac muscle cell apoptotic process	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
response to nutrient levels	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
protein demalonylation	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
peptidyl-lysine demalonylation	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
protein desuccinylation	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
peptidyl-lysine desuccinylation	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
protein deglutarylation	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
epigenetic regulation of gene expression	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Process	via Protein(s)	Taxonomy
NAD+ ADP-ribosyltransferase activity	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
NAD+-protein ADP-ribosyltransferase activity	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
zinc ion binding	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
NAD-dependent protein lysine deacetylase activity	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
protein-malonyllysine demalonylase activity	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
protein-succinyllysine desuccinylase activity	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
protein-glutaryllysine deglutarylase activity	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
NAD+ binding	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Process	via Protein(s)	Taxonomy
nucleus	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
mitochondrion	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
mitochondrial intermembrane space	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
mitochondrial matrix	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
cytosol	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
mitochondrial matrix	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay ID	Title	Year	Journal	Article
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	1 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.56 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.36 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.05	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.05	1	0